GB2132087A - Germicidal and disinfectant composition - Google Patents

Germicidal and disinfectant composition Download PDF

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Publication number
GB2132087A
GB2132087A GB08333114A GB8333114A GB2132087A GB 2132087 A GB2132087 A GB 2132087A GB 08333114 A GB08333114 A GB 08333114A GB 8333114 A GB8333114 A GB 8333114A GB 2132087 A GB2132087 A GB 2132087A
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United Kingdom
Prior art keywords
germicidal
composition according
active agent
agent
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08333114A
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GB8333114D0 (en
Inventor
Nola Fabio Di
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMICAL MEDIC HALL Ltd
Original Assignee
CHEMICAL MEDIC HALL Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMICAL MEDIC HALL Ltd filed Critical CHEMICAL MEDIC HALL Ltd
Priority to GB08333114A priority Critical patent/GB2132087A/en
Publication of GB8333114D0 publication Critical patent/GB8333114D0/en
Publication of GB2132087A publication Critical patent/GB2132087A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof

Abstract

A germicidal and disinfectant composition comprises: (a) a germicidal cationic surface- active agent (b) an antiseptic agent (c) a non-ionic surface active agent The germicidal cationic surface active agent is preferably an alkyl dimethylbenzyl ammonium chloride of the general formula <IMAGE> wherein R is an alkyl group having 8 to 18 carbon atoms (i.e. C8H17 to C18H37). The antiseptic agent is preferably chlorexidine (C22H30Cl2). The composition preferably comprises a carrier, such as silica gel. The invention enables the rate of release of germicidal and disinfectant agent, in use of the composition, to remain substantially constant for a period of time even though the amount of germicidal and disinfectant agent in the composition is decreasing.

Description

SPECIFICATION Germicidal and disinfectant composition The present invention relates to a germicidal and disinfectant composition.
Various known germicidal and disinfectant compositions have the property of giving gradual or sustained release of germicidal and disinfectant agent at their site of use. A disadvantage of such known compositions is that the rate of release of the germicidal and disinfectant agent diminishes with time as the amount of germicidal and disinfectant agent present in the composition decreases.
It would be desirable to provide a germicidal and disinfectant composition, particularly for use for hygenic purposes, wherein, in use, the rate of release of germicidal and disinfectant agent remains substantially constant for a period of time even though the amount of germicidal and disinfectant agent in the composition is decreasing.
With this end in view, the present invention provides a germicidal and disinfectant composition, comprising: (a) a germicidal cationic surface-active agent (b) an antiseptic agent (c) a non-ionic surface active agent.
The germicidal cationic surface active agent is preferably an alkyl dimethylbenzyl ammonium chloride of the general formula
where R is an alkyl group having 8 to 18 carbon atoms (i.e. C8H17 to C18H37).
The antiseptic agent is preferably chlorexidine (C22H30C12).
Chlorexidine is 1,1 '-hexamethylenebis 5(p-chlorophenyidiguanido)hexane 1,6 di(4'chlorophenyldiguanido)hexane and has the structural formula:
The chlorexidine may be present in the composition of the invention as the hydrochloride.
Chlorexidine is commercially available under the trade name Nolvasan from Imperial Chemical (Pharmaceuticals) Limited.
The non-ionic surface active agent is preferably an alkyl aryl polyether alcohol, such as commercially available under the trade name Triton X-120.
The composition preferably comprises a carrier, such as silica gel.
The composition may be in the form of a powder or may be in larger particulate form such as granules.
We have found that there is a synergistic action between components (a) and (b).
In a preferred aspect of the invention, the composition comprises: (a) 40 to 60% by weight of the germicidal cationic surface active agent; (b) 4 to 6% by weight of the antiseptic agent; (c) 1 to 3% by weight of the non-ionic surface active agent; and (d) 29 to 57% by weight of the carrier, these percentages being based on the total weight of components (a) to (d).
More preferably the composition comprises 54 to 57% of component (a), 5 to 6% of component (b), 2 to 3% of component (c) and 34 to 39% of component (d).
The invention is illustrated by the following examples.
Example 1 A composition was prepared comprising the following components in the stated amounts: (a) benzalkonium chloride 50% by weight (b) chlorexidine dihydrochloride 5% by weight (calculated as chlorexidine) (c) Triton X-120 2% by weight (d) Silicasol 43% by weight Benzalkonium chloride is a mixture of alkyl dimethylbenzyl ammonium chlorides of the general formula given above where R ranges from C8H37 to C18H37. Benzalkonium chloride is commercially available under the trade names Zephiran chloride, Zephirol, BTC, Roccal, Benirol, Germitol, Drapolene, Cequartyl, Germinol and Rodalonsvar.
Silicasol is the trade name of a commercially available silica gel.
To prepare the composition, components (a), (b) and (c) were mixed in an aqueous colloidal solution of the Silicasol to form a slurry having dry matter content of 60 to 65% by weight i.e. a water content of 35 to 40% by weight.
The solution was then pumped into a tower and atomized therein. Hot air was passed upwardly through the tower and as droplets of the solution descended in the tower, water evaporated therefrom and the silica gel flocculated, solid particles of silica gel containing components (a), (b) and (c) being formed. The components (a), (b) and (c) were mainly present in the pores of the particles of silica gel. The solid flocculated particles were in the form of beads.
The solid flocculated particles of silica gel were passed through a vibrating screen. It was found that the particles could, if desired be shaped and compacted into larger bodies e.g. in the shape of parallelpipeds.
It was found that when the composition, either as the flocculated particles or as the larger shaped bodies, were exposed to water or other solvent, either once or repeatedly, each of the active components (a), (b) or (c) were released therefrom at a substantially constant rate until substantially completely exhausted.
Moreover, it was found that there was a synergistic action or effect between the components (a) and (b).
The product (i.e. the solid flocculated particles) was tested to determine its efficacy against Escherichia coli and Staphylococcuspyog. aureus.
Suspensions in physiological solution were prepared from the product and these suspensions at various dilutions were introduced into a plurality of test tubes. To each test tube was added a suspension of a microorganism, also in physiological solution, to give the product concentrations given in Table 1 below.
To each test tube was then added a suspension of one of the microorganisms referred to in Table 1 below to give the final product concentrations given in the table.
From each test tube a sample was taken by means of a platinum loop of three aliquots and each aliquot was placed in a further test tube containing approximately 10 ml of Quisno-Foter-Gibby liquid earth with added lecithin.
The latter test tubes were incubated at 37"C for one week. At 24 hours, 48 hours, 4 days and 7 days tests were carried out to determine whether the earth in the test tubes contained live microorganisms.
For carrying out the tests, 24 hour agar plates of the contents of the latter test tubes were prepared and, at the moment of the test, sterile distilled water was added to the plates to obtain from each plate suspensions containing on average one thousand million microorganisms per millilitre.
Simultaneously, suspensions of the product were prepared in tests with concentrations double those to be tested (final dilutions of 1/100, 1/500, 1/1000).
10 ml quantities of the solutions were introduced into test tubes and tests as described above were carried out to assess the activity of the product.
The results are given in Table 1 below: TABLE 1 Final Period of Contact Mircoorganism Product 1 5 15 30 Concentration minute minutes minutes minutes Escherichia coli 1/5 - - - - - - - - - - - - 1/10 - - - - - - - - - - - - 1/100 - - - - - - - - - - - 1/500 - - - - - - - - - - - 1/1000 + - - - + - - - - - - 1/2500 + + - - - - - - - - - Staph. pyog aureus. 1/5 - - - - - - - - - - - 1/10 - - - - - - - - - - - 1/100 - - - - - - - - - - - 1/500 - - - - - - - - - - - 1/1000 + + + - + - - - - - - 1/2500 - + + + - + - - - - - Product concentration is expressed as weight of product (9)/ volume of physiological solution (ml.) The symbols + and - indicate that live microorganisms respectively were and were not present in the sample examined i.e. that microbe development had and had not respectively occurred.
Substantially similar results to those described above were obtained when the tests were repeated using product containing chlorexidine diacetate instead of chlorexidine dihydrochloride.
Example 2 Table 2 below demonstrates the synergism which occurs between the components of the composition according to the invention and which is a function of the ratio of the concentration of the components.
Referring to Table 2, BZ1, BZM and BZE are compositions according to the invention and, except for the modifications described below, prepared as described in Example 1.
In BZ1, component (c) i.e. alkyl dimethylbenzyl ammonium chloride is present in an amount of 40 to 50% by weight.
In BZM, component (a) is present in an amount of from 25 to 39% by weight.
In BZE, component (b) is chloramine instead of chlorexidine dihydrochloride.
TABLE 2 815818 OCM CH Microorganisms Product Dilution of Escherichia coli St. pyog. aureus Ps. Aeruginosa C. Albicans B. Subtilis Sample P.C. P.C. P.C. P.C.
1 5 15 1 5 15 1 5 15 1 5 15 1 5 15 BZ1 1/100 --+ --- --- --- --- --- --- --- --- +++ +++ +++ +++ +++ +++ 1/500 +++ +++ --- --- --- --- +++ +++ --- +++ +++ +++ +++ +++ +++ 1/1000 +++ -± --- -± --- --- +++ +++ ±- +++ +++ +++ +++ +++ +++ BZM 1/100 +++ +++ --- --- --- --- +++ +++ +± +++ +++ +++ +++ +++ +++ 1/500 +++ +++ ±- --- --- --- +++ +++ +++ +++ +++ +++ +++ +++ +++ 1/1000 +++ --- ±- --- --- --- +++ +++ +++ +++ +++ +++ +++ +++ +++ BZE 1/100 +++ --- --- --- --- --- +++ +++ +++ +++ +++ +++ +++ +++ +++ 1/500 +++ +++ +++ +++ --- --- +++ +++ +++ +++ +++ +++ +++ +++ +++ 1/1000 +++ +++ +++ +++ +++ --- +++ +++ +++ +++ +++ +++ +++ +++ +++ P.C.=period of contact in minutes Dilution are expressed as in Table 1 The symbols + and - have the meanings given in connection with Table 1 Microbe development check = positive + = development - = no development The BZ1 formula indicates the greatest activity both in general and in comparison with the single microbe divisions used for the test.
If desired additives such as colouring agents and perfuming agents may be incorporated into the composition according to the invention.

Claims (12)

1. A germicidal and disinfectant composition, comprising: (a) a germicidal cationic surface-active agent; (b) an antiseptic agent; (c) a non-ionic surface active agent.
2. A composition according to claim 1, wherein the germicidal cationic surface active agent is an alkyl dimethylbenzyl ammonium chloride of the general formula
where R is an alkyl group having 8 to 18 carbon atoms.
3. A composition according to either preceding claim, wherein the antiseptic agent is chlorexidine.
4. A composition according to claim 3, wherein the chlorexidine is present as chlorexidine dihydrochloride (C22H30C12N10.2HCl) or chlorexidine diacetate (C22H30C12N10 (CH3COOH)2).
5. A composition according to any preceding claim, wherein the non-ionic surface-active agent is an alkyl aryl polyetheralcohol.
6. A composition according to any preceding claim, further comprising a carrier.
7. A composition according to claim 6, wherein the carrier is a silica gel.
8. A composition according to claim 8, wherein components (a), (b) and (c) are contained substantially within the pores of the silica gel.
9. A composition according to any of claims 6 to 8, comprising (a) 40 to 60% by weight of the germicidal cationic surface-active agent; (b) 4 to 6% by weight of the antiseptic agent; (c) 1 to 3% by weight of the non-ionic surface-active agent; and (d) 29 to 57% by weight of the carrier; these percentages being based on the total weight of components (a) to (d).
10. A composition according to claim 1, substantially as described herein by way of example.
11. A process for preparing a composition according to claim 7, comprising suspending components (a) to (c) in a colloidal solution of silica and then atomizing the solution thereby to cause flocculation of the solution to give solid particles of silica gel containing the components (a) to (c).
12. A process according to claim 11, substantially as described in Example 1.
GB08333114A 1982-12-10 1983-12-12 Germicidal and disinfectant composition Withdrawn GB2132087A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB08333114A GB2132087A (en) 1982-12-10 1983-12-12 Germicidal and disinfectant composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8235205 1982-12-10
GB08333114A GB2132087A (en) 1982-12-10 1983-12-12 Germicidal and disinfectant composition

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GB2132087A true GB2132087A (en) 1984-07-04

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255239A1 (en) * 1986-07-31 1988-02-03 Betz Europe, Inc. Biocidal compositions and use thereof
WO1988002351A1 (en) * 1986-09-24 1988-04-07 Great Lakes Chemical Corporation The control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
US4976874A (en) * 1987-04-20 1990-12-11 Great Lakes Chemical Corporation Control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
US4978685A (en) * 1986-09-24 1990-12-18 Great Lakes Chemical Corporation Control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
FR2686221A1 (en) * 1992-01-22 1993-07-23 Hutchinson Compositions based on antiseptics and their applications
EP0555116A2 (en) * 1992-01-22 1993-08-11 Hutchinson Compositions based on antiseptics and their applications
FR2691325A1 (en) * 1992-05-21 1993-11-26 Hutchinson Synergistic antiseptic compsns.
FR2752731A1 (en) * 1996-08-28 1998-03-06 Pioch Michel Antiseptic compositions for use in dentistry
EP0827691A1 (en) * 1996-09-06 1998-03-11 Peters Decontaminating and cleaning composition in powder form and process for obtaining it
US6436445B1 (en) 1999-03-26 2002-08-20 Ecolab Inc. Antimicrobial and antiviral compositions containing an oxidizing species
WO2002095148A1 (en) * 2001-05-23 2002-11-28 Alejandro Espinosa Garcia Biodegradable germicidal and water-saving composition for toilets
US6534075B1 (en) 1999-03-26 2003-03-18 Ecolab Inc. Antimicrobial and antiviral compositions and treatments for food surfaces

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB641297A (en) * 1947-03-26 1950-08-09 Gen Aniline & Film Corp Germicidal detergent compositions
GB663565A (en) * 1947-12-04 1951-12-27 Gen Aniline & Film Corp Germicidal detergent composition
GB795814A (en) * 1954-12-24 1958-05-28 Ici Ltd Bactericidal detergent compositions
GB1069356A (en) * 1965-01-26 1967-05-17 Rewo Chem Fab G M B H Detergent mixtures comprising anionic detergents and cation-active compounds
GB1226985A (en) * 1967-07-12 1971-03-31
GB1449821A (en) * 1972-10-27 1976-09-15 Ici Ltd Aqueous compositions
GB1453443A (en) * 1973-10-23 1976-10-20 Ici Ltd Aqueous compositions
GB1483186A (en) * 1973-09-21 1977-08-17 Ici Ltd Aqueous wetting compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB641297A (en) * 1947-03-26 1950-08-09 Gen Aniline & Film Corp Germicidal detergent compositions
GB663565A (en) * 1947-12-04 1951-12-27 Gen Aniline & Film Corp Germicidal detergent composition
GB795814A (en) * 1954-12-24 1958-05-28 Ici Ltd Bactericidal detergent compositions
GB1069356A (en) * 1965-01-26 1967-05-17 Rewo Chem Fab G M B H Detergent mixtures comprising anionic detergents and cation-active compounds
GB1226985A (en) * 1967-07-12 1971-03-31
GB1449821A (en) * 1972-10-27 1976-09-15 Ici Ltd Aqueous compositions
GB1483186A (en) * 1973-09-21 1977-08-17 Ici Ltd Aqueous wetting compositions
GB1453443A (en) * 1973-10-23 1976-10-20 Ici Ltd Aqueous compositions

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255239A1 (en) * 1986-07-31 1988-02-03 Betz Europe, Inc. Biocidal compositions and use thereof
WO1988002351A1 (en) * 1986-09-24 1988-04-07 Great Lakes Chemical Corporation The control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
US4978685A (en) * 1986-09-24 1990-12-18 Great Lakes Chemical Corporation Control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
US4976874A (en) * 1987-04-20 1990-12-11 Great Lakes Chemical Corporation Control of biofouling in aqueous systems by non-polymeric quaternary ammonium polyhalides
EP0555116A3 (en) * 1992-01-22 1993-10-06 Hutchinson Compositions based on antiseptics and their applications
EP0555116A2 (en) * 1992-01-22 1993-08-11 Hutchinson Compositions based on antiseptics and their applications
FR2686221A1 (en) * 1992-01-22 1993-07-23 Hutchinson Compositions based on antiseptics and their applications
FR2691325A1 (en) * 1992-05-21 1993-11-26 Hutchinson Synergistic antiseptic compsns.
FR2752731A1 (en) * 1996-08-28 1998-03-06 Pioch Michel Antiseptic compositions for use in dentistry
EP0827691A1 (en) * 1996-09-06 1998-03-11 Peters Decontaminating and cleaning composition in powder form and process for obtaining it
FR2753049A1 (en) * 1996-09-06 1998-03-13 Peters CLEANING AND DECONTAMINANT POWDER COMPOSITION AND PROCESS FOR OBTAINING
US6436445B1 (en) 1999-03-26 2002-08-20 Ecolab Inc. Antimicrobial and antiviral compositions containing an oxidizing species
US6534075B1 (en) 1999-03-26 2003-03-18 Ecolab Inc. Antimicrobial and antiviral compositions and treatments for food surfaces
WO2002095148A1 (en) * 2001-05-23 2002-11-28 Alejandro Espinosa Garcia Biodegradable germicidal and water-saving composition for toilets

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