GB2127408B - Improvements in or relating to benzimidazoles - Google Patents
Improvements in or relating to benzimidazolesInfo
- Publication number
- GB2127408B GB2127408B GB08325360A GB8325360A GB2127408B GB 2127408 B GB2127408 B GB 2127408B GB 08325360 A GB08325360 A GB 08325360A GB 8325360 A GB8325360 A GB 8325360A GB 2127408 B GB2127408 B GB 2127408B
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzimidazoles
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/424,784 US4492708A (en) | 1982-09-27 | 1982-09-27 | Antiviral benzimidazoles |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8325360D0 GB8325360D0 (en) | 1983-10-26 |
GB2127408A GB2127408A (en) | 1984-04-11 |
GB2127408B true GB2127408B (en) | 1986-05-14 |
Family
ID=23683858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08325360A Expired GB2127408B (en) | 1982-09-27 | 1983-09-22 | Improvements in or relating to benzimidazoles |
Country Status (13)
Country | Link |
---|---|
US (1) | US4492708A (fr) |
EP (1) | EP0111993A3 (fr) |
JP (1) | JPS5980666A (fr) |
KR (1) | KR840006215A (fr) |
AU (1) | AU1956683A (fr) |
DD (1) | DD207714A5 (fr) |
DK (1) | DK438983D0 (fr) |
FI (1) | FI833424A (fr) |
GB (1) | GB2127408B (fr) |
GR (1) | GR79047B (fr) |
PL (1) | PL243905A1 (fr) |
PT (1) | PT77398B (fr) |
ZA (1) | ZA836958B (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728741A (en) * | 1985-01-08 | 1988-03-01 | Smithkline Beckman Corporation | 1-substituted-2-mercapto benzimidazole compounds and intermediates |
HU193951B (en) * | 1985-03-11 | 1987-12-28 | Richter Gedeon Vegyeszet | Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them |
FR2593177B1 (fr) * | 1986-01-20 | 1988-04-01 | Novapharme | Nouveaux benzimidazo |
SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US5750532A (en) * | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
US5272167A (en) * | 1986-12-10 | 1993-12-21 | Schering Corporation | Pharmaceutically active compounds |
AU6062590A (en) * | 1989-07-07 | 1991-02-06 | Schering Corporation | Pharmaceutically active compounds |
TW203049B (fr) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
US5614519A (en) * | 1991-02-06 | 1997-03-25 | Karl Thomae Gmbh | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists |
US5602127A (en) * | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
US5594003A (en) * | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
ATE163290T1 (de) * | 1991-06-24 | 1998-03-15 | Neurosearch As | Imidazol-verbindungen, verfahren zu ihrer herstellung und ihre anwendung |
US5210091A (en) * | 1991-06-24 | 1993-05-11 | Neurosearch A/S | Imidazole compounds and their use |
CA2085844A1 (fr) * | 1991-12-27 | 1993-06-28 | Nobuyuki Hamanaka | Derives fusionnes de l'acide benzeneoxyacetique |
DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
US5399580A (en) * | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
US5545653A (en) * | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
US5693661A (en) * | 1995-06-07 | 1997-12-02 | Eli Lilly And Company | Anti-viral compounds |
GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
US5891874A (en) * | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
CA2257296A1 (fr) * | 1996-06-05 | 1997-12-11 | Mark Joseph Tebbe | Composes antiviraux |
US5821242A (en) * | 1996-06-06 | 1998-10-13 | Eli Lilly And Company | Anti-viral compounds |
CZ299810B6 (cs) * | 1996-08-12 | 2008-12-03 | Celgene Corporation | Substituovaná aromatická sloucenina a její použití pro snížení hladiny cytokinu |
WO1998031363A1 (fr) * | 1997-01-22 | 1998-07-23 | Eli Lilly And Company | Composes antiviraux |
WO1998055120A1 (fr) * | 1997-06-04 | 1998-12-10 | Eli Lilly And Company | Composes antiviraux |
US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
EP1434579B1 (fr) * | 2001-10-09 | 2011-06-08 | Amgen Inc. | Derives d'imidazole comme agents anti-inflammatoires |
US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
KR20050117533A (ko) * | 2003-03-05 | 2005-12-14 | 셀진 코포레이션 | 디페닐에틸렌 화합물 및 그의 용도 |
EP1697343B1 (fr) * | 2003-12-18 | 2009-07-01 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles et benzimidazoles comme inhibiteurs de replication du virus respiratoire syncytial |
MXPA06007640A (es) | 2004-01-12 | 2007-04-17 | Cytopia Res Pty Ltd | Inhibidores de quinasa selectivos. |
WO2006028963A2 (fr) * | 2004-09-03 | 2006-03-16 | Celgene Corporation | Composes heterocycliques substitues et leurs utilisations |
EP1917251B1 (fr) | 2005-08-21 | 2013-04-03 | Abbott GmbH & Co. KG | Composes 5-cycle-heteroaromates et leur utilisation en tant que partenaires de liaison des recepteurs 5-ht5 |
FR2892719B3 (fr) * | 2005-11-02 | 2008-01-18 | Sep Innovaterm | Barriere physico-chimique anti-termites constituee par du beton dans lequel a ete incorpore dans toute la masse un insecticide contre les termites |
US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
EP1988776B1 (fr) * | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Médicaments antiviraux pour le traitement d'une infection à arénavirus |
US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
ES2424214T3 (es) | 2007-08-27 | 2013-09-30 | Siga Technologies, Inc. | Medicamentos antivirales para el tratamiento de una infección por Arenavirus |
US20130303781A1 (en) * | 2010-11-24 | 2013-11-14 | Sequent Scientific Limited | Process for preparation of triclabendazole |
EP2643304A2 (fr) * | 2010-11-24 | 2013-10-02 | Sequent Scientific Ltd. | Procédé de préparation d'albendazole |
WO2016025744A1 (fr) * | 2014-08-13 | 2016-02-18 | University Of Virginia Patent Foundation | Traitements anticancéreux |
WO2019031990A1 (fr) * | 2017-08-07 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Nouveaux composés hétérocycliques comme inhibiteurs de cdk8/19 |
WO2021189080A1 (fr) * | 2020-03-18 | 2021-09-23 | The Board Of Regents Of The University Of Texas System | Méthodes et compositions pour le traitement de la grippe |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1045534A (en) * | 1963-02-09 | 1966-10-12 | Schering Ag | New 1-benzyl-5,6-dialkoxy benzimidazoles and a process for their manufacture |
FR1384313A (fr) * | 1963-02-09 | 1965-01-04 | Schering Ag | Nouveaux dérivés du benzimidazole et leur préparation |
US3336191A (en) * | 1966-03-11 | 1967-08-15 | Smith Kline French Lab | Anthelmintic 2-amidobenzimidazoles |
FR1513160A (fr) * | 1966-03-24 | 1968-02-09 | Alfa Laval Ab | Centrifugeuse |
US3936702A (en) * | 1972-02-24 | 1976-02-03 | Micro Devices Corporation | Electrical protection means |
US3825537A (en) * | 1972-02-28 | 1974-07-23 | Squibb & Sons Inc | 1-thiazolin-2-yl(or thiazin-2-yl)-2-aminobenzimidazoles and derivatives thereof |
US3813409A (en) * | 1972-07-31 | 1974-05-28 | Squibb & Sons Inc | Benzimidazolinone compounds |
US4026936A (en) * | 1975-08-07 | 1977-05-31 | Hoffmann-La Roche Inc. | Anthelmintic pyridine and thiazole substituted benzimidazole carbamates |
MX3654E (es) * | 1975-08-28 | 1981-04-14 | Lilly Co Eli | Procedimiento para preparar compuestos de sulfonilbencimidazol |
US4174454A (en) * | 1975-08-28 | 1979-11-13 | Eli Lilly And Company | Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles |
CA1076582A (fr) * | 1975-10-28 | 1980-04-29 | Charles J. Paget | Thiazolinyle ou thiazinyle cetobenzimidazoles antiviraux |
US4008243A (en) * | 1975-11-19 | 1977-02-15 | Eli Lilly And Company | Antiviral thiazolinyl or thiazinyl benzimidazole esters |
LU75684A1 (fr) * | 1976-08-27 | 1978-04-13 | ||
US4191832A (en) * | 1979-03-12 | 1980-03-04 | Eli Lilly And Company | Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles |
US4230868A (en) * | 1979-04-17 | 1980-10-28 | Eli Lilly And Company | α-Alkyl-α-hydroxybenzyl-substituted 1-sulfonylbenzimidazoles |
US4316021A (en) * | 1979-08-13 | 1982-02-16 | Eli Lilly And Company | Substituted 1-sulfonylbenzimidazoles |
US4338329A (en) * | 1979-11-14 | 1982-07-06 | Eli Lilly And Company | Antiviral method employing 1-sulfonylbenzimidazoles |
US4338315A (en) * | 1979-11-14 | 1982-07-06 | Eli Lilly And Company | Antiviral method employing thiazinyl benzimidazole derivatives |
-
1982
- 1982-09-27 US US06/424,784 patent/US4492708A/en not_active Expired - Fee Related
-
1983
- 1983-09-19 GR GR72474A patent/GR79047B/el unknown
- 1983-09-19 ZA ZA836958A patent/ZA836958B/xx unknown
- 1983-09-22 EP EP83305611A patent/EP0111993A3/fr not_active Ceased
- 1983-09-22 GB GB08325360A patent/GB2127408B/en not_active Expired
- 1983-09-23 FI FI833424A patent/FI833424A/fi not_active Application Discontinuation
- 1983-09-26 PT PT77398A patent/PT77398B/pt unknown
- 1983-09-26 KR KR1019830004492A patent/KR840006215A/ko not_active IP Right Cessation
- 1983-09-26 PL PL24390583A patent/PL243905A1/xx unknown
- 1983-09-26 DK DK4389/83A patent/DK438983D0/da not_active Application Discontinuation
- 1983-09-26 AU AU19566/83A patent/AU1956683A/en not_active Abandoned
- 1983-09-27 JP JP58181743A patent/JPS5980666A/ja active Pending
- 1983-09-27 DD DD83255127A patent/DD207714A5/de unknown
Also Published As
Publication number | Publication date |
---|---|
PT77398B (en) | 1986-03-20 |
AU1956683A (en) | 1984-04-05 |
DD207714A5 (de) | 1984-03-14 |
KR840006215A (ko) | 1984-11-22 |
EP0111993A2 (fr) | 1984-06-27 |
PL243905A1 (en) | 1985-01-30 |
JPS5980666A (ja) | 1984-05-10 |
PT77398A (en) | 1983-10-01 |
GB8325360D0 (en) | 1983-10-26 |
FI833424A0 (fi) | 1983-09-23 |
EP0111993A3 (fr) | 1984-07-25 |
GB2127408A (en) | 1984-04-11 |
DK438983D0 (da) | 1983-09-26 |
US4492708A (en) | 1985-01-08 |
FI833424A (fi) | 1984-03-28 |
GR79047B (fr) | 1984-10-02 |
ZA836958B (en) | 1985-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |