GB2090135A - A Composition for the Topical Treatment of Acne - Google Patents
A Composition for the Topical Treatment of Acne Download PDFInfo
- Publication number
- GB2090135A GB2090135A GB8119333A GB8119333A GB2090135A GB 2090135 A GB2090135 A GB 2090135A GB 8119333 A GB8119333 A GB 8119333A GB 8119333 A GB8119333 A GB 8119333A GB 2090135 A GB2090135 A GB 2090135A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- composition according
- peroxide
- erythromycin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 109
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 19
- 206010000496 acne Diseases 0.000 title claims abstract description 19
- 230000000699 topical effect Effects 0.000 title claims abstract description 12
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims abstract description 110
- 229960003276 erythromycin Drugs 0.000 claims abstract description 64
- 150000002978 peroxides Chemical class 0.000 claims abstract description 39
- -1 erythromycin compound Chemical class 0.000 claims abstract description 33
- 239000004342 Benzoyl peroxide Substances 0.000 claims abstract description 28
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000019400 benzoyl peroxide Nutrition 0.000 claims abstract description 28
- 239000004615 ingredient Substances 0.000 claims abstract description 24
- 239000004480 active ingredient Substances 0.000 claims abstract description 12
- 150000007524 organic acids Chemical class 0.000 claims abstract description 6
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 23
- 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 claims description 14
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 14
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims description 14
- 239000003085 diluting agent Substances 0.000 claims description 12
- 239000003349 gelling agent Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 239000005995 Aluminium silicate Substances 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 claims description 3
- 235000012211 aluminium silicate Nutrition 0.000 claims description 3
- 229910000323 aluminium silicate Inorganic materials 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 125000002348 vinylic group Chemical group 0.000 claims description 3
- YAVZHCFFUATPRK-YZPBMOCRSA-N Erythromycin stearate Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 YAVZHCFFUATPRK-YZPBMOCRSA-N 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 229960004142 erythromycin stearate Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 125000005233 alkylalcohol group Chemical group 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- FATUQANACHZLRT-KMRXSBRUSA-L calcium glucoheptonate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O FATUQANACHZLRT-KMRXSBRUSA-L 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 description 16
- 239000000499 gel Substances 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 4
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 4
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 2
- 229940043276 diisopropanolamine Drugs 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 229960001047 methyl salicylate Drugs 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920000151 polyglycol Polymers 0.000 description 2
- 239000010695 polyglycol Substances 0.000 description 2
- 229940099429 polyoxyl 40 stearate Drugs 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 239000012258 stirred mixture Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical class CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- AWFYPPSBLUWMFQ-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=C2 AWFYPPSBLUWMFQ-UHFFFAOYSA-N 0.000 description 1
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 101710158368 Extracellular lipase Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010058015 Infected cyst Diseases 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- 244000127759 Spondias lutea Species 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 101710128940 Triacylglycerol lipase Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960003328 benzoyl peroxide Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE287481A IE52227B1 (en) | 1980-12-08 | 1981-12-08 | A composition for the topical treatment of acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21412480A | 1980-12-08 | 1980-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2090135A true GB2090135A (en) | 1982-07-07 |
Family
ID=22797872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8119333A Withdrawn GB2090135A (en) | 1980-12-08 | 1981-06-23 | A Composition for the Topical Treatment of Acne |
| GB8136777A Expired GB2088717B (en) | 1980-12-08 | 1981-12-07 | A composition for the topical treatment of acne |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8136777A Expired GB2088717B (en) | 1980-12-08 | 1981-12-07 | A composition for the topical treatment of acne |
Country Status (18)
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0209724A3 (en) * | 1985-06-18 | 1988-07-06 | Biogal Gyogyszergyar | Preparation effective against acne and the use of an active extract of couch grass |
| EP0291960A3 (en) * | 1987-05-19 | 1990-09-12 | Yakurigaku Chuo Kenkyusho Kk | Novel synthetic aluminum silicate preparation |
| WO1993020796A1 (en) * | 1992-04-09 | 1993-10-28 | Allergan, Inc. | Method and composition for treating acne |
| US5260292A (en) * | 1991-03-05 | 1993-11-09 | Marvin S. Towsend | Topical treatment of acne with aminopenicillins |
| WO1995031978A1 (en) * | 1994-05-19 | 1995-11-30 | The Procter & Gamble Company | Anti-acne compositions |
| US6495158B1 (en) | 2001-01-19 | 2002-12-17 | Lec Tec Corporation | Acne patch |
| WO2011070170A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | Novel peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne |
| WO2011070171A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | Derivatives of novel peroxides, method of preparation thereof and use thereof in human medicine as well as in cosmetics for the treatment or prevention of acne |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA837627B (en) * | 1982-10-15 | 1984-06-27 | Procter & Gamble | Storage stable topical pharmaceutical composition containing low dielectric solvents |
| EP0109102B1 (en) * | 1982-10-15 | 1988-01-20 | THE PROCTER & GAMBLE COMPANY | Storage stable topical pharmaceutical composition including nitrogen-containing stabilizers |
| FR2558372B1 (fr) * | 1984-01-25 | 1987-08-07 | Oreal | Composition medicamenteuse pour le traitement de l'acne |
| FR2604357B1 (fr) * | 1986-09-30 | 1988-12-02 | Oreal | Composition pharmaceutique et cosmetique anti-acneique |
| TW203552B (en) * | 1992-02-18 | 1993-04-11 | J Baroody Lloyd | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| JP2001509477A (ja) * | 1997-07-08 | 2001-07-24 | デーエスエム・ナムローゼ・フェンノートシャップ | ベンゾイルペルオキシドと第二活性成分との組合せの局所適用 |
| DE19917548A1 (de) * | 1999-04-19 | 2000-10-26 | August Wolff Gmbh & Co Arzneim | Pharmazeutische Zusammensetzung auf der Basis von Erythromycin-Fettsäuresalzen mit 12 bis 22 Kohlenstoffatomen im Fettsäurerest und Verwendung dieser Erythromycin-Fettsäuresalze zur topischen Behandlung von Hauterkrankungen |
| WO2001091726A1 (en) * | 2000-06-02 | 2001-12-06 | Dermik International Holding Inc. | Acne-treating composition |
| US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| GB0301577D0 (en) * | 2003-01-23 | 2003-02-26 | Edko Pazarlama Tanitim Ltd Sti | Topical pharmaceutical and/or cosmetic dispense systems |
| WO2006099192A2 (en) * | 2005-03-10 | 2006-09-21 | Jr Chem, Llc | Stable organic peroxide compositions |
| WO2007092312A2 (en) | 2006-02-03 | 2007-08-16 | Stiefel Laboratories, Inc. | Topical skin treating compositions |
| CA2656451C (en) * | 2006-07-13 | 2015-01-27 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
| FR2903604B1 (fr) | 2006-07-13 | 2008-09-05 | Galderma Res & Dev S N C Snc | Composition comprenant un retinoide et du peroxyde de benzoyle |
| FR2910320B1 (fr) | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| US12350382B2 (en) | 2007-02-01 | 2025-07-08 | Mayne Pharma Llc | Method for preparing particles comprising metal oxide coating and particles with metal oxide coating |
| MX2010013152A (es) * | 2008-06-05 | 2011-05-02 | Dow Pharmaceutical Sciences | Formulaciones farmaceuticas topicas que contienen una baja concentracion de peroxido de benzoilo en suspension en agua y un solvente organico miscibe en agua. |
| WO2019012537A1 (en) | 2017-07-12 | 2019-01-17 | Sol-Gel Technologies Ltd | COMPOSITIONS COMPRISING ENCAPSULATED TRETTINOIN |
| JP6525074B2 (ja) | 2017-07-31 | 2019-06-05 | 大日本印刷株式会社 | 熱転写シート、印画シートと熱転写シートとの組合せ、及び熱転写印画装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2748399C2 (de) * | 1976-11-01 | 1983-09-15 | The Procter & Gamble Co., 45202 Cincinnati, Ohio | Antimikrobielles Mittel zur örtlichen Anwendung |
| FR2378523A1 (fr) * | 1977-01-26 | 1978-08-25 | Grupper Charles | Medicament pour le traitement de l'acne |
-
1981
- 1981-06-18 IT IT8167845A patent/IT1210608B/it active
- 1981-06-19 CA CA000380219A patent/CA1179599A/en not_active Expired
- 1981-06-22 AU AU72029/81A patent/AU557147B2/en not_active Expired
- 1981-06-22 FR FR8112233A patent/FR2495471A1/fr not_active Withdrawn
- 1981-06-22 NL NL8102997A patent/NL8102997A/nl not_active Application Discontinuation
- 1981-06-22 DK DK273981A patent/DK273981A/da not_active Application Discontinuation
- 1981-06-22 ZA ZA814215A patent/ZA814215B/xx unknown
- 1981-06-22 BE BE0/205167A patent/BE889327A/fr not_active IP Right Cessation
- 1981-06-22 ES ES503797A patent/ES8303087A1/es not_active Expired
- 1981-06-22 NZ NZ197491A patent/NZ197491A/xx unknown
- 1981-06-23 SE SE8103925A patent/SE8103925L/xx unknown
- 1981-06-23 GB GB8119333A patent/GB2090135A/en not_active Withdrawn
- 1981-06-24 DE DE19813124698 patent/DE3124698A1/de active Granted
- 1981-06-24 PH PH25809A patent/PH19245A/en unknown
- 1981-06-25 CH CH4215/81A patent/CH647147A5/de not_active IP Right Cessation
- 1981-06-25 CH CH186/85A patent/CH656307A5/de not_active IP Right Cessation
- 1981-06-26 AT AT0285581A patent/AT381452B/de not_active IP Right Cessation
- 1981-07-27 AR AR286227A patent/AR229405A1/es active
- 1981-10-27 JP JP56170865A patent/JPS5799525A/ja active Pending
- 1981-12-07 GB GB8136777A patent/GB2088717B/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0209724A3 (en) * | 1985-06-18 | 1988-07-06 | Biogal Gyogyszergyar | Preparation effective against acne and the use of an active extract of couch grass |
| EP0291960A3 (en) * | 1987-05-19 | 1990-09-12 | Yakurigaku Chuo Kenkyusho Kk | Novel synthetic aluminum silicate preparation |
| US5260292A (en) * | 1991-03-05 | 1993-11-09 | Marvin S. Towsend | Topical treatment of acne with aminopenicillins |
| WO1993020796A1 (en) * | 1992-04-09 | 1993-10-28 | Allergan, Inc. | Method and composition for treating acne |
| WO1995031978A1 (en) * | 1994-05-19 | 1995-11-30 | The Procter & Gamble Company | Anti-acne compositions |
| CN1079669C (zh) * | 1994-05-19 | 2002-02-27 | 赫英尔柯特赫尔曼两合公司 | 防痤疮组合物 |
| US6495158B1 (en) | 2001-01-19 | 2002-12-17 | Lec Tec Corporation | Acne patch |
| WO2011070170A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | Novel peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne |
| WO2011070171A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | Derivatives of novel peroxides, method of preparation thereof and use thereof in human medicine as well as in cosmetics for the treatment or prevention of acne |
| US9102607B2 (en) | 2009-12-10 | 2015-08-11 | Galderma Research & Development | Peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA285581A (de) | 1986-03-15 |
| BE889327A (fr) | 1981-10-16 |
| AR229405A1 (es) | 1983-08-15 |
| AT381452B (de) | 1986-10-27 |
| GB2088717B (en) | 1984-12-12 |
| DK273981A (da) | 1982-09-09 |
| IT8167845A0 (it) | 1981-06-18 |
| CH647147A5 (de) | 1985-01-15 |
| ES503797A0 (es) | 1983-03-01 |
| NZ197491A (en) | 1985-02-28 |
| DE3124698A1 (de) | 1982-07-08 |
| FR2495471A1 (fr) | 1982-06-11 |
| ES8303087A1 (es) | 1983-03-01 |
| IT1210608B (it) | 1989-09-14 |
| DE3124698C2 (enrdf_load_stackoverflow) | 1992-06-25 |
| CH656307A5 (de) | 1986-06-30 |
| ZA814215B (en) | 1983-02-23 |
| AU557147B2 (en) | 1986-12-11 |
| JPS5799525A (en) | 1982-06-21 |
| NL8102997A (nl) | 1982-07-01 |
| CA1179599A (en) | 1984-12-18 |
| PH19245A (en) | 1986-02-14 |
| GB2088717A (en) | 1982-06-16 |
| AU7202981A (en) | 1982-06-17 |
| SE8103925L (sv) | 1982-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |