JP5317968B2 - レチノイドと過酸化ベンゾイルとを含む組成物 - Google Patents
レチノイドと過酸化ベンゾイルとを含む組成物 Download PDFInfo
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- JP5317968B2 JP5317968B2 JP2009518885A JP2009518885A JP5317968B2 JP 5317968 B2 JP5317968 B2 JP 5317968B2 JP 2009518885 A JP2009518885 A JP 2009518885A JP 2009518885 A JP2009518885 A JP 2009518885A JP 5317968 B2 JP5317968 B2 JP 5317968B2
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960004311 betamethasone valerate Drugs 0.000 description 1
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 1
- 235000020682 bottled natural mineral water Nutrition 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- KQWGXHWJMSMDJJ-UHFFFAOYSA-N cyclohexyl isocyanate Chemical compound O=C=NC1CCCCC1 KQWGXHWJMSMDJJ-UHFFFAOYSA-N 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- LAWOZCWGWDVVSG-UHFFFAOYSA-N dioctylamine Chemical compound CCCCCCCCNCCCCCCCC LAWOZCWGWDVVSG-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 229940031674 laureth-7 Drugs 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960001144 mizolastine Drugs 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940093426 poloxamer 182 Drugs 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dispersion Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
特に、皮膚炎の治療において、コルチコステロイド(例えば、ヒドロコルチゾン、ミコナゾール、またはベタメタゾンバレレートなど)、抗ヒスタミン剤(例えば、ミゾラスチン)、および/または角質溶解剤(例えば、サリチル酸)を使用することが周知である。さまざまな抗真菌剤(例えば、アリルアミン誘導体、トリアゾールなど)、抗細菌剤または抗微生物剤(例えば、抗生物質、キノロン、およびイミダゾールなど)も、皮膚科学的疾患の治療において従来組み合わされている。過酸化物、ビタミンD、およびレチノイドも、皮膚または粘膜と関連する各種の病変、特にざ瘡の局所的治療を目的として記載されている。
いくつかの局所的治療の組み合わせ(抗生物質、レチノイド、過酸化物、および亜鉛)も、活性成分の効力を増大させ、その毒性を低下させるために皮膚科学において使用されている(Cunliffe W.J., J. Dermatol. Treat., 2000, 11 (suppl. 2), pp. 513-514)。
各種の皮膚科学製品の複数回の適用は、患者にとってかなり煩わしく制限的なものであろう。
したがって、皮膚科学的病変に有効であり、良好な化粧品の使用性を与える安定な組成物を用い、かつ、単一回での適用と患者にとって快適な使用性とを可能にする、新規な治療法を得るための探求の価値が理解されるであろう。
過酸化ベンゾイルゲルのこの不安定性は、その有効性および化粧品品質を損なう。
− 少なくとも1種のレチノイド;
− 過酸化ベンゾイル;および
− 少なくとも2つのカテゴリーの化合物類を含むゲル化剤の組み合わせ物
を含み、
前記カテゴリーの化合物類が、シリケート、セルロースゲル化剤、およびポリサッカライドガムから選択され、
ここで、少なくとも2種のゲル化剤が、マグネシウムアルミニウムシリケート、キサンタンガム、およびヒドロキシプロピルセルロースから選択される場合には、前記ゲル化システムが、前記2種のゲル化剤のみからなるか、あるいは前記3種の化合物類とは異なるゲル化剤を少なくとも1種さらに含むことを条件とする組成物に関する。
6-(3-メチルフェニル)-2-ナフトエ酸およびそのメチルエステル;
6-(4-tert-ブチルフェニル)-2-ナフトエ酸およびそのメチルエステル;
6-(3-tert-ブチルフェニル)-2-ナフトエ酸およびそのメチルエステル;
6-(3,4-ジメトキシフェニル)-2-ナフトエ酸およびそのメチルエステル;
6-(p-(1-アダマンチルチオ)フェニル)-2-ナフトエ酸およびそのメチルエステル;
6-(3-(1-アダマンチル)-4-メトキシフェニル)-2-ナフトエ酸(アダパレン)およびそのメチルエステル;
6-[3-(1-アダマンチル)-4-tert-ブチルジメチルシロキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-ヒドロキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-ヒドロキシフェニル)-2-ナフトエ酸;
6-[3-(1-アダマンチル)-4-デシルオキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-デシルオキシフェニル) -2-ナフトエ酸;
6-[3-(1-アダマンチル)-4-ヘキシルオキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-ヘキシルオキシフェニル)-2-ナフトエ酸;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-4-アセトキシ-1-メチル-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-4-ヒドロキシ-1-メチル-2-ナフトエ酸;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-4-ヒドロキシ-1-メチル-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-メトキシフェニル) -1-メチル-2-ナフトエ酸のメチルエステル;
6-[3-(1-アダマンチル)-4-メトキシフェニル)- 1-メチル-2-ナフトエ酸;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-2-ナフタレンメタノール;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-2-ナフトエ酸のエチルアミド;
6-[3-(1-アダマンチル)-4-メトキシフェニル)-2-ナフトエ酸のモルホリド;
6-[3-tert-ブチル-4-メトキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-tert-ブチル-4-メトキシフェニル)-2-ナフトエ酸;
6-[3-(1,1-ジメチルデシル)-4-メトキシフェニル)-2-ナフトエ酸のメチルエステル;
6-[3-(1,1-ジメチルデシル)-4-メトキシフェニル)-2-ナフトエ酸
である。
好ましく使用される湿潤剤として、これらだけに限定されないが、ポロキサマーファミリーの化合物、とりわけポロキサマー124および/またはポロキサマー182を挙げることができる。
− 20〜90%の水;
− 0〜10%、好ましくは0〜2%、特に0〜0.5%の湿潤性液体界面活性剤;
− 0〜20%、好ましくは0〜10%、特に2〜5%の浸透促進剤;
− 0.0001〜20%、好ましくは0.025〜10%の過酸化ベンゾイル;
− 0.0001〜20%、好ましくは0.001〜10%のレチノイド;および
− 0.11〜25%の上述したゲル化システム
を含む(重量パーセンテージで表す)活性相を含むことを特徴とする組成物に関する。
− 2.5%の過酸化ベンゾイル;
− 0.1%のアダパレン;
− 0.1%のEDTA二ナトリウム;
− 2%〜4%のグリセロール;
− 2%〜6%(好ましくは、2%、4%、または5%)のプロピレングリコール;
− 0%〜0.05%のドキュセートナトリウム;
− 2%〜4%の上述したゲル化システム;および
− 0.2%〜0.5%のポロキサマー124
を含む。
アダパレン 0.1%
過酸化ベンゾイル BPOが2.5%となる適量
プロピレングリコール 4%
ポロキサマー124 0.1%
マグネシウムアルミニウムシリケート 2%
ヒドロキシエチルセルロース 1.5%
キサンタンガム 0.5%
グリセロール 2%
ドキュセートナトリウム 0.05%
を含む。
1)分化および増殖に関連する角化障害に伴う皮膚科学的疾患の治療、特に尋常性座瘡、面皰性座瘡または多形性座瘡、酒さ性座瘡、結節嚢腫性座瘡、集簇性座瘡、老人性座瘡または二次的座瘡(例えば日光性座瘡)、薬物性座瘡または職業性座瘡、および化膿性汗腺炎の治療;
2)その他のタイプの角化障害、特に魚鱗癬、魚鱗癬様の状態、ダリエー病、掌蹠角皮症、白斑症および白斑症様の状態ならびに皮膚のまたは粘膜(口腔)の苔癬の治療;
3)炎症および/または免疫アレルギー性要素を有する角化障害に伴う他の皮膚科学的疾患、および、特に、皮膚、粘膜、または爪の乾癬のいずれであるかにかかわらず全ての形態の乾癬、ならびに、乾癬性リューマチ、または皮膚アトピー(例えば湿疹または呼吸性アトピーなど)、または歯内肥大の治療;本化合物は、毛包炎のような角化障害を示さない特定の炎症性疾患において使用することもできる;
4)良性であるかまたは悪性であるかにかかわらず、およびウイルス起源であるか否かにかかわらず、全ての皮膚または表皮の増殖、例えば、尋常性ゆうぜい、扁平ゆうぜい、伝染性軟属腫、およびゆうぜい状表皮異形成、葉状口腔乳頭腫症、および紫外線によって引き起こされ得る増殖、特に、化学線によって誘導される増殖、特に角化症の治療;
5)光誘導性の老化であるかまたは加齢性の老化であるかにかかわらず、皮膚の老化の修復または解消、色素沈着の軽減、または光誘導性もしくは加齢性の老化に伴ういずれかの病理の軽減;
6)創傷治癒障害または皮膚潰瘍の予防的なまたは治癒的な治療、皮膚萎縮線条の予防または修復、または創傷治癒の促進;
7)脂腺機能障害、例えば脂漏過剰性座瘡、単純性脂漏の治療;
8)真菌由来の何らかの皮膚疾患、例えば足白癬および癜風の治療;
9)免疫学的要素を有する皮膚科学疾患の治療;
10)UV線への曝露に起因する皮膚疾患の治療;および
11)毛髪の小胞の周辺組織の炎症または感染に伴う皮膚科学的疾患、特に、微生物コロニー形成または感染に起因する疾患、特に、膿痂疹、脂漏性皮膚炎、毛包炎、または毛瘡、または細菌性もしくは真菌性の病原体が関与する何らかの他の疾患の治療。
a)シリケート/トラガカントガム
a)シリケート/セルロース/キサンタンガム
巨視的外観:白く、なめらかであり、光沢のある製品。
微視的外観:両方の活性剤が良好に分散している。
アダパレン:HPLCにおける内部較正法による活性の分析。
開始時(T0)に、組成物のアダパレンの濃度が100%であるとみなす。T0と比較してアダパレンの濃度を%で測定した。
開始時(T0)に、組成物の過酸化ベンゾイルの濃度が100%であるとみなす。T0と比較して過酸化ベンゾイルの濃度を%で測定した。
Claims (21)
- 生理学的に許容可能な媒体中に、
− 少なくとも1種のレチノイド;
− 過酸化ベンゾイル;および
−少なくとも1種のシリケート、少なくとも1種のセルロースゲル化剤、および少なくとも1種のポリサッカライドガムを含むゲル化剤の組み合わせ物、
を含み、
ここで、少なくとも2種の前記ゲル化剤が、マグネシウムアルミニウムシリケート、キサンタンガム、およびヒドロキシプロピルセルロースから選択される場合には、前記ゲル化剤組み合わせ物が、前記3種の化合物類とは異なるゲル化剤を少なくとも1種さらに含むことを条件とする、組成物。 - 前記シリケートが、マグネシウムアルミニウムシリケートであることを特徴とする、請求項1に記載の組成物。
- シリケートの量が、前記組成物の総重量に対して0.1重量%〜10重量%であることを特徴とする、請求項1または2に記載の組成物。
- 前記セルロースゲル化剤が、メチルセルロース、エチルセルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、ヒドロキシメチルセルロース、およびヒドロキシプロピルセルロースから選択されることを特徴とする、請求項1から3のいずれか一項に記載の組成物。
- セルロースゲル化剤の量が、前記組成物の総重量に対して0.1重量%〜10重量%であることを特徴とする、請求項1から4のいずれか一項に記載の組成物。
- ポリサッカライドガムの量が、前記組成物の総重量に対して0.01重量%〜5重量%であることを特徴とする、請求項1から5のいずれか一項に記載の組成物。
- 0.0001重量%〜20重量%のレチノイドを含むことを特徴とする、請求項1から6のいずれか一項に記載の組成物。
- 前記レチノイドがアダパレンであることを特徴とする、請求項1から7のいずれか一項に記載の組成物。
- 0.0001重量%〜20重量%の過酸化ベンゾイルを含むことを特徴とする、請求項1から8のいずれか一項に記載の組成物。
- 前記過酸化ベンゾイルが、カプセル化されているかあるいは遊離していることを特徴とする、請求項1から9のいずれか一項に記載の組成物。
- 浸透促進剤を含むことを特徴とする、請求項1から10のいずれか一項に記載の組成物。
- 前記浸透促進剤がプロピレングリコールであることを特徴とする、請求項11に記載の組成物。
- 7から12のHLB値を有する界面活性剤並びにポリオキシエチレン化コポリマータイプ及び/又はポリオキシプロピレン化コポリマータイプの非イオン性界面活性剤なる群から選択される湿潤性液体界面活性剤を含むことを特徴とする、請求項1から12のいずれか一項に記載の組成物。
- 前記湿潤性液体界面活性剤がポロキサマーであることを特徴とする、請求項13に記載の組成物。
- − 2.5%の過酸化ベンゾイル;
− 0.1%のアダパレン;
− 0.1%のEDTA二ナトリウム;
− 2%〜4%のグリセロール;
− 2%〜6%のプロピレングリコール;
− 0.05%以下のドキュセートナトリウムを含むか又はドキュセートナトリウムを含まず;
− 2%〜4%のゲル化剤組み合わせ物;および
− 0.2%〜0.5%のポロキサマー124;
を水中に含むことを特徴とする、請求項1から14のいずれか一項に記載の組成物。 - アダパレン 0.1%
過酸化ベンゾイル 2.5%
プロピレングリコール 4%
ポロキサマー124 0.1%
マグネシウムアルミニウムシリケート 2%
ヒドロキシエチルセルロース 1.5%
キサンタンガム 0.5%
グリセロール 2%
ドキュセートナトリウム 0.05%
を水中に含むことを特徴とする、請求項1から14のいずれか一項に記載の組成物。 - 医薬品としての、請求項1から16のいずれか一項に記載の組成物。
- 細胞分化、増殖疾患および角化障害から選択される皮膚科学疾患の予防および/または治療のための製薬調製物の製造のための、請求項1から17のいずれか一項に記載の組成物の使用。
- 前記皮膚科学疾患の予防および/または治療が、
1)尋常性座瘡、面皰性座瘡または多形性座瘡、酒さ性座瘡、結節嚢腫性座瘡、集簇性座瘡、老人性座瘡または二次的座瘡、薬物性座、職業性座瘡、および化膿性汗腺炎の治療;
2)魚鱗癬、魚鱗癬様の状態、ダリエー病、掌蹠角皮症、白斑症および白斑症様の状態ならびに皮膚のまたは粘膜(口腔)の苔癬の治療;
3)皮膚、粘膜、または爪の乾癬のいずれであるかにかかわらず全ての形態の乾癬、乾癬性リューマチ、皮膚アトピー、歯内肥大、毛包炎の治療;
4)良性であるかまたは悪性であるかにかかわらず、およびウイルス起源であるか否かにかかわらず、全ての皮膚または表皮の増殖、葉状口腔乳頭腫症、および紫外線によって引き起こされる角化症の治療;
5)光誘導性の老化であるかまたは加齢性の老化であるかにかかわらず、皮膚の老化の修復または解消、色素沈着の軽減;
6)創傷治癒障害または皮膚潰瘍の予防的なまたは治癒的な治療、皮膚萎縮線条の予防または修復、または創傷治癒の促進;
7)脂腺機能障害の治療;
8)真菌由来の皮膚疾患の治療;並びに
9)膿痂疹、脂漏性皮膚炎、毛包炎、または毛瘡、あるいは細菌性もしくは真菌性の病原体が関与する他の疾患の治療、
からなる群から選択される、請求項18に記載の使用。 - 前記1)の二次的座瘡が日光性座瘡であり、前記3)の皮膚アトピーが湿疹または呼吸性アトピーであり、前記4)の皮膚または表皮の増殖が尋常性ゆうぜい、扁平ゆうぜい、伝染性軟属腫、およびゆうぜい状表皮異形成であり、前記7)の脂腺機能障害が脂漏過剰性座瘡及び単純性脂漏であり、前記8)真菌由来の皮膚疾患が足白癬および癜風である、請求項19に記載の使用。
- 尋常性ざ瘡の予防および/または治療のための製薬調製物の製造のための、請求項1〜17のいずれか一項に記載の組成物の使用。
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Application Number | Priority Date | Filing Date | Title |
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FR0652967A FR2903604B1 (fr) | 2006-07-13 | 2006-07-13 | Composition comprenant un retinoide et du peroxyde de benzoyle |
FR0652967 | 2006-07-13 | ||
US83209206P | 2006-07-21 | 2006-07-21 | |
US60/832,092 | 2006-07-21 | ||
PCT/EP2007/057091 WO2008006848A1 (en) | 2006-07-13 | 2007-07-11 | Composition comprising a retinoid and benzoyl peroxide |
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US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
WO2008006848A1 (en) * | 2006-07-13 | 2008-01-17 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
RU2481832C2 (ru) * | 2007-01-30 | 2013-05-20 | Галдерма Ресерч Энд Девелопмент | Применение адапалена и пероксида бензоила для продолжительного лечения угрей обыкновенных |
US20090131521A1 (en) * | 2007-10-18 | 2009-05-21 | Wortzman Mitchell S | Aqueous retinoid and benzoyl peroxide gel |
CN105287484A (zh) | 2007-11-30 | 2016-02-03 | 盖尔德马研究及发展公司 | 含有萘甲酸衍生物、过氧化苯甲酰和成膜剂的组合物 |
FR2969492B1 (fr) * | 2010-12-23 | 2013-07-05 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene |
FR2969491B1 (fr) * | 2010-12-23 | 2013-07-12 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant une combinaison d'adapalene et de bpo |
EP3082785A1 (en) * | 2013-12-19 | 2016-10-26 | Galderma Research & Development | Therapy regimen for treating severe acne related diseases |
JP6865159B2 (ja) * | 2014-08-20 | 2021-04-28 | スリーエム イノベイティブ プロパティズ カンパニー | 硫酸塩還元微生物用の内蔵型嫌気性培養デバイス |
ES2970434T3 (es) | 2014-09-12 | 2024-05-28 | Union Therapeutics As | Uso antibacteriano de salicilanilidas halogenadas |
GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
US20180235924A1 (en) * | 2015-08-20 | 2018-08-23 | Sol-Gel Technologies Ltd. | Compositions for topical application comprising benzoyl peroxide and adapalene |
GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
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US4355028A (en) * | 1978-04-04 | 1982-10-19 | Westwood Pharmaceuticals, Inc. | Composition for treating acne vulgaris |
NZ194326A (en) * | 1979-07-25 | 1982-05-31 | Dermik Lab Inc | Stable aqueous benzoyl peroxide compositions and therapeutic compositions |
IT1210608B (it) * | 1980-12-08 | 1989-09-14 | Rorer Int Overseas | Composizione per il trattamento topico dell'acne |
LU84485A1 (fr) * | 1982-11-22 | 1984-06-13 | Oreal | Nouvelle composition anti-acneique a base de peroxyde de benzoyle et d'au moins un autre principe actif |
FR2687312A1 (fr) * | 1992-02-14 | 1993-08-20 | Denner Alfred | Compositions pour application cutanee destinees au traitement et a la prevention des rides et des cernes palpebrales. |
IL105217A0 (en) * | 1992-04-09 | 1993-07-08 | Allergan Inc | Method and composition for treating acne |
FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
WO2008006848A1 (en) * | 2006-07-13 | 2008-01-17 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
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