GB2080524B - Determining endotoxin with a limulus amebocyte lysate reagent - Google Patents

Determining endotoxin with a limulus amebocyte lysate reagent

Info

Publication number
GB2080524B
GB2080524B GB8119357A GB8119357A GB2080524B GB 2080524 B GB2080524 B GB 2080524B GB 8119357 A GB8119357 A GB 8119357A GB 8119357 A GB8119357 A GB 8119357A GB 2080524 B GB2080524 B GB 2080524B
Authority
GB
United Kingdom
Prior art keywords
amebocyte lysate
limulus amebocyte
lysate reagent
determining endotoxin
endotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8119357A
Other languages
English (en)
Other versions
GB2080524A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26859656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2080524(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of GB2080524A publication Critical patent/GB2080524A/en
Application granted granted Critical
Publication of GB2080524B publication Critical patent/GB2080524B/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
GB8119357A 1980-06-27 1981-06-23 Determining endotoxin with a limulus amebocyte lysate reagent Expired GB2080524B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16345680A 1980-06-27 1980-06-27
US06/254,233 US4322217A (en) 1980-06-27 1981-04-14 Process for preparing Limulus lysate

Publications (2)

Publication Number Publication Date
GB2080524A GB2080524A (en) 1982-02-03
GB2080524B true GB2080524B (en) 1984-04-18

Family

ID=26859656

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8119357A Expired GB2080524B (en) 1980-06-27 1981-06-23 Determining endotoxin with a limulus amebocyte lysate reagent

Country Status (9)

Country Link
US (1) US4322217A (enExample)
AU (1) AU545395B2 (enExample)
CH (1) CH647871A5 (enExample)
DE (1) DE3125181A1 (enExample)
FR (1) FR2485740A1 (enExample)
GB (1) GB2080524B (enExample)
IT (1) IT1211070B (enExample)
NL (1) NL8103113A (enExample)
SE (1) SE447029B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827557D0 (en) * 1988-11-25 1988-12-29 Radiometer Corporate Dev Ltd Process for handling horseshoe crab amoebocyte lysate
US5002015A (en) * 1988-12-09 1991-03-26 Aerotrace Hydraulics, Inc. Submerged treadmill system for exercising animals
DK0426395T3 (enExample) * 1989-10-30 1997-03-03 Biowhittaker Inc
JP2957251B2 (ja) * 1990-09-28 1999-10-04 生化学工業株式会社 エンドトキシンの測定法
EP0549102B1 (en) * 1991-12-25 1996-07-03 Maruha Corporation Beta-glucans detection reagents and methods of detecting beta-glucans
JP2737514B2 (ja) * 1992-01-24 1998-04-08 和光純薬工業株式会社 エンドトキシン測定用試料の前処理方法
CA2112776C (en) * 1993-01-21 2002-11-12 Masakazu Tsuchiya Process for inhibiting activity of endotoxin
JP3242733B2 (ja) * 1993-02-26 2001-12-25 生化学工業株式会社 エンドトキシン特異的測定剤
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US5637474A (en) * 1994-10-31 1997-06-10 Wako Pure Chemical Industries, Ltd. Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method
US6270982B1 (en) 1997-10-09 2001-08-07 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins
US6849426B2 (en) * 2001-06-28 2005-02-01 Cambrex Bio Science Walkersville, Inc. Methods and reagents for detecting endotoxin
US7828741B2 (en) * 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
US20040138577A1 (en) * 2002-12-20 2004-07-15 Kline Jeffrey A. Disposable hand-held device for collection of exhaled breath condensate
WO2004073497A2 (en) * 2003-02-14 2004-09-02 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
US7329538B2 (en) 2003-03-17 2008-02-12 Charles River Laboratories, Inc. Methods and compositions for the detection of microbial contaminants
US20050048655A1 (en) * 2003-04-18 2005-03-03 Novitsky Thomas J. Kit for detecting endotoxin
US20050026239A1 (en) * 2003-04-18 2005-02-03 Associates Of Cape Cod, Inc. Kit for detecting endotoxin in aqueous solutions
US7968280B2 (en) * 2004-12-02 2011-06-28 Charles River Laboratories, Inc. Methods for the detection and/or quantification of gram positive bacterial contaminants
DE602006004553D1 (de) * 2005-01-13 2009-02-12 Charles River Lab Inc Verfahren zur klassifizierung von mikroben in einer biologischen probe
WO2009137244A1 (en) * 2008-04-15 2009-11-12 Charles River Laboratories, Inc. Cartridge and method for sample analysis
EP2147981A1 (en) 2008-07-25 2010-01-27 Biotype AG Kit and method for evaluating detection properties in amplification reactions
JP5437660B2 (ja) 2009-02-19 2014-03-12 興和株式会社 コアギュロゲン原料及びその製造方法、それを用いた生物由来の生理活性物質の測定方法及び測定装置
MY155541A (en) * 2010-10-29 2015-10-30 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
IL264464B2 (en) 2016-08-03 2024-02-01 Lonza Walkersville Inc A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen
US12158471B2 (en) 2022-02-11 2024-12-03 Charles River Laboratories, Inc. Recombinant amebocyte lysate and uses thereof
CN121443750A (zh) 2023-06-05 2026-01-30 查尔斯河实验室公司 重组变形细胞凝血因子及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280179A (en) * 1961-03-16 1966-10-18 Textilana Corp Processes for producing acyclic surfactant sulfobetaines
US3368978A (en) * 1964-12-28 1968-02-13 Monsanto Co Builder compositions and detergent compositions using same
US3539521A (en) * 1965-05-03 1970-11-10 Procter & Gamble Detergent composition
US3915805A (en) * 1970-05-25 1975-10-28 Univ Johns Hopkins Quantitative detection of endotoxin in biological fluids
US3954663A (en) * 1972-12-18 1976-05-04 Teikoku Horinine Mfg. Co. Ltd. Process for the preparation of Limulina lysate
US4096091A (en) * 1974-07-17 1978-06-20 Baxter Travenol Laboratories, Inc. Limulus lysate having improved capacity to precipitate in the presence of low endotoxin concentrations, and reconstituting solutions therefor
US3944391A (en) 1974-12-27 1976-03-16 Preventive Systems, Inc. In vitro process for detecting endotoxin in a biological fluid
US4107077A (en) * 1975-07-14 1978-08-15 Associates Of Cape Cod, Inc. Limulus lysate of improved sensitivity and preparing the same
US4038029A (en) * 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
GB1522127A (en) 1976-07-23 1978-08-23 Mallinckrodt Inc Limulus amebocyte lysate reagent compositions
GB2019563B (en) 1978-04-20 1982-07-28 Harvard College Assay of gram-negative bacteria
DE2927103A1 (de) * 1978-10-06 1980-04-17 Baxter Travenol Lab Optisches verfahren zur bestimmung von endotoxin
US4273557A (en) * 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins

Also Published As

Publication number Publication date
FR2485740A1 (fr) 1981-12-31
AU7232181A (en) 1982-01-07
CH647871A5 (fr) 1985-02-15
NL192139C (enExample) 1997-02-04
US4322217A (en) 1982-03-30
FR2485740B1 (enExample) 1985-05-24
SE447029B (sv) 1986-10-20
DE3125181C2 (enExample) 1991-09-05
DE3125181A1 (de) 1982-03-04
GB2080524A (en) 1982-02-03
SE8104016L (sv) 1981-12-28
IT8122595A0 (it) 1981-06-26
NL192139B (enExample) 1996-10-01
AU545395B2 (en) 1985-07-11
NL8103113A (nl) 1982-01-18
IT1211070B (it) 1989-09-29

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 20010622