GB2080524B - Determining endotoxin with a limulus amebocyte lysate reagent - Google Patents

Determining endotoxin with a limulus amebocyte lysate reagent

Info

Publication number
GB2080524B
GB2080524B GB8119357A GB8119357A GB2080524B GB 2080524 B GB2080524 B GB 2080524B GB 8119357 A GB8119357 A GB 8119357A GB 8119357 A GB8119357 A GB 8119357A GB 2080524 B GB2080524 B GB 2080524B
Authority
GB
United Kingdom
Prior art keywords
amebocyte lysate
limulus amebocyte
lysate reagent
determining endotoxin
endotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8119357A
Other languages
English (en)
Other versions
GB2080524A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26859656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2080524(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of GB2080524A publication Critical patent/GB2080524A/en
Application granted granted Critical
Publication of GB2080524B publication Critical patent/GB2080524B/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8119357A 1980-06-27 1981-06-23 Determining endotoxin with a limulus amebocyte lysate reagent Expired GB2080524B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16345680A 1980-06-27 1980-06-27
US06/254,233 US4322217A (en) 1980-06-27 1981-04-14 Process for preparing Limulus lysate

Publications (2)

Publication Number Publication Date
GB2080524A GB2080524A (en) 1982-02-03
GB2080524B true GB2080524B (en) 1984-04-18

Family

ID=26859656

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8119357A Expired GB2080524B (en) 1980-06-27 1981-06-23 Determining endotoxin with a limulus amebocyte lysate reagent

Country Status (9)

Country Link
US (1) US4322217A (cg-RX-API-DMAC7.html)
AU (1) AU545395B2 (cg-RX-API-DMAC7.html)
CH (1) CH647871A5 (cg-RX-API-DMAC7.html)
DE (1) DE3125181A1 (cg-RX-API-DMAC7.html)
FR (1) FR2485740A1 (cg-RX-API-DMAC7.html)
GB (1) GB2080524B (cg-RX-API-DMAC7.html)
IT (1) IT1211070B (cg-RX-API-DMAC7.html)
NL (1) NL8103113A (cg-RX-API-DMAC7.html)
SE (1) SE447029B (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827557D0 (en) * 1988-11-25 1988-12-29 Radiometer Corporate Dev Ltd Process for handling horseshoe crab amoebocyte lysate
US5002015A (en) * 1988-12-09 1991-03-26 Aerotrace Hydraulics, Inc. Submerged treadmill system for exercising animals
ES2098256T3 (es) * 1989-10-30 1997-05-01 Biowhittaker Inc Ensayo cinetico para la endotoxina utilizando lisado amebocitico de limulus y sustrato cromogenico.
JP2957251B2 (ja) * 1990-09-28 1999-10-04 生化学工業株式会社 エンドトキシンの測定法
EP0549102B1 (en) * 1991-12-25 1996-07-03 Maruha Corporation Beta-glucans detection reagents and methods of detecting beta-glucans
JP2737514B2 (ja) * 1992-01-24 1998-04-08 和光純薬工業株式会社 エンドトキシン測定用試料の前処理方法
CA2112776C (en) * 1993-01-21 2002-11-12 Masakazu Tsuchiya Process for inhibiting activity of endotoxin
JP3242733B2 (ja) * 1993-02-26 2001-12-25 生化学工業株式会社 エンドトキシン特異的測定剤
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US5637474A (en) * 1994-10-31 1997-06-10 Wako Pure Chemical Industries, Ltd. Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method
US6270982B1 (en) * 1997-10-09 2001-08-07 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins
WO2003002976A2 (en) * 2001-06-28 2003-01-09 Biowhittaker, Inc. Methods and reagents for detecting endotoxin
US7828741B2 (en) * 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
EP1571985B1 (en) * 2002-12-20 2009-04-01 The Charlotte-Mecklenburg Hospital Authority Disposable hand-held device for collection of exhaled breath condensate
WO2004073497A2 (en) * 2003-02-14 2004-09-02 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
DE602004024769D1 (de) * 2003-03-17 2010-02-04 Charles River Lab Inc Methoden und zusammensetzungen für den nachweis mikrobieller verunreinigungen
US20050048655A1 (en) * 2003-04-18 2005-03-03 Novitsky Thomas J. Kit for detecting endotoxin
WO2004094987A2 (en) * 2003-04-18 2004-11-04 Associates Of Cape Cod, Inc. Kit for detecting endotoxin in aqueous solutions
WO2007078268A2 (en) * 2004-12-02 2007-07-12 Charles River Laboratories, Inc. Methods and compositions for the detection and/or quantification of gram positive bacterial contaminants
ATE419526T1 (de) * 2005-01-13 2009-01-15 Charles River Lab Inc Verfahren zur klassifizierung von mikroben in einer biologischen probe
US20090286692A1 (en) * 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
EP2147981A1 (en) 2008-07-25 2010-01-27 Biotype AG Kit and method for evaluating detection properties in amplification reactions
JP5437660B2 (ja) 2009-02-19 2014-03-12 興和株式会社 コアギュロゲン原料及びその製造方法、それを用いた生物由来の生理活性物質の測定方法及び測定装置
MY155541A (en) * 2010-10-29 2015-10-30 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
WO2018026941A1 (en) 2016-08-03 2018-02-08 Lonza Walkersville, Inc. Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen
US12158471B2 (en) 2022-02-11 2024-12-03 Charles River Laboratories, Inc. Recombinant amebocyte lysate and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280179A (en) * 1961-03-16 1966-10-18 Textilana Corp Processes for producing acyclic surfactant sulfobetaines
US3368978A (en) * 1964-12-28 1968-02-13 Monsanto Co Builder compositions and detergent compositions using same
US3539521A (en) * 1965-05-03 1970-11-10 Procter & Gamble Detergent composition
US3915805A (en) * 1970-05-25 1975-10-28 Univ Johns Hopkins Quantitative detection of endotoxin in biological fluids
US3954663A (en) * 1972-12-18 1976-05-04 Teikoku Horinine Mfg. Co. Ltd. Process for the preparation of Limulina lysate
US4096091A (en) * 1974-07-17 1978-06-20 Baxter Travenol Laboratories, Inc. Limulus lysate having improved capacity to precipitate in the presence of low endotoxin concentrations, and reconstituting solutions therefor
US3944391A (en) 1974-12-27 1976-03-16 Preventive Systems, Inc. In vitro process for detecting endotoxin in a biological fluid
US4107077A (en) * 1975-07-14 1978-08-15 Associates Of Cape Cod, Inc. Limulus lysate of improved sensitivity and preparing the same
US4038029A (en) * 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
GB1522127A (en) 1976-07-23 1978-08-23 Mallinckrodt Inc Limulus amebocyte lysate reagent compositions
GB2019563B (en) 1978-04-20 1982-07-28 Harvard College Assay of gram-negative bacteria
DE2927103A1 (de) 1978-10-06 1980-04-17 Baxter Travenol Lab Optisches verfahren zur bestimmung von endotoxin
US4273557A (en) * 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins

Also Published As

Publication number Publication date
IT8122595A0 (it) 1981-06-26
FR2485740A1 (fr) 1981-12-31
NL192139C (cg-RX-API-DMAC7.html) 1997-02-04
NL8103113A (nl) 1982-01-18
DE3125181C2 (cg-RX-API-DMAC7.html) 1991-09-05
SE447029B (sv) 1986-10-20
FR2485740B1 (cg-RX-API-DMAC7.html) 1985-05-24
SE8104016L (sv) 1981-12-28
IT1211070B (it) 1989-09-29
AU545395B2 (en) 1985-07-11
US4322217A (en) 1982-03-30
AU7232181A (en) 1982-01-07
GB2080524A (en) 1982-02-03
CH647871A5 (fr) 1985-02-15
DE3125181A1 (de) 1982-03-04
NL192139B (cg-RX-API-DMAC7.html) 1996-10-01

Similar Documents

Publication Publication Date Title
GB2080524B (en) Determining endotoxin with a limulus amebocyte lysate reagent
GB2045431B (en) Immunoassay utilising two particulate reagents
MX152152A (es) Mejoras a manguera con inserciones de resorte para uso industrial y automotriz
BE892055A (nl) Kabel met verbeterde vermoeiingsweerstand
DE3173154D1 (en) Beta-hydroxybutyrate polymers
IT8267756A0 (it) Strumento indicatore elettrico con rimessa a zero
GB2141100B (en) Multiple splicing assembly
ES252888Y (es) Barril con tapones
DK73182A (da) Fejlsikkert boelgestop
JPS57197222A (en) Malaria antibody
BR8103064A (pt) Indicacao eletrootica sem reflexao
IT8249689A0 (it) Munizione dirompente in un sol pezzo
IL59383A (en) Micromethod for the determination of endotoxins with limulus amebocyte lysate
JPS57196154A (en) Monochronal antibody
EP0032774A3 (en) Optical reflection meter
DE3269455D1 (en) Pluggable connection with a switchable contacting bridge
JPS57130367A (en) Reflection lamp
SG28186G (en) Parallel comparator
BR8207987A (pt) Mecanismo acionado a fichas com dispositivo magentico de separacao
GB8419529D0 (en) Determining environmental pollutants
GB8325681D0 (en) Measuring distances between two opposite surfaces
GB2099994B (en) Determining coating thickness
DE3173420D1 (en) Friction element
BR8108395A (pt) Linha de transmissao isolada com gas comprimido
BR8205429A (pt) Mola a gas com conexao de montagem rapida

Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 20010622