GB2018258B - 3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids - Google Patents

3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids

Info

Publication number
GB2018258B
GB2018258B GB7911796A GB7911796A GB2018258B GB 2018258 B GB2018258 B GB 2018258B GB 7911796 A GB7911796 A GB 7911796A GB 7911796 A GB7911796 A GB 7911796A GB 2018258 B GB2018258 B GB 2018258B
Authority
GB
United Kingdom
Prior art keywords
halocorticoids
trienes
dienes
acetoxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7911796A
Other languages
English (en)
Other versions
GB2018258A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prochem Ets
Original Assignee
Prochem Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prochem Ets filed Critical Prochem Ets
Publication of GB2018258A publication Critical patent/GB2018258A/en
Application granted granted Critical
Publication of GB2018258B publication Critical patent/GB2018258B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
GB7911796A 1978-04-05 1979-04-04 3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids Expired GB2018258B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL7803656 1978-04-05
NL7803655 1978-04-05
NLAANVRAGE7902333,A NL187577C (nl) 1978-04-05 1979-03-23 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.

Publications (2)

Publication Number Publication Date
GB2018258A GB2018258A (en) 1979-10-17
GB2018258B true GB2018258B (en) 1983-02-02

Family

ID=27352047

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7911796A Expired GB2018258B (en) 1978-04-05 1979-04-04 3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids

Country Status (9)

Country Link
US (1) US4255331A (US06534493-20030318-C00288.png)
JP (1) JPS6425793A (US06534493-20030318-C00288.png)
CH (1) CH639655A5 (US06534493-20030318-C00288.png)
DE (1) DE2913147A1 (US06534493-20030318-C00288.png)
FI (1) FI66395C (US06534493-20030318-C00288.png)
FR (1) FR2421914A1 (US06534493-20030318-C00288.png)
GB (1) GB2018258B (US06534493-20030318-C00288.png)
NL (1) NL187577C (US06534493-20030318-C00288.png)
PH (1) PH16138A (US06534493-20030318-C00288.png)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
EP0029924B1 (en) 1979-11-16 1984-08-15 STEROSYNT Ltd. 6-alpha-fluoro-16-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them
HU182775B (en) * 1981-10-15 1984-03-28 Richter Gedeon Vegyeszet Process for preparing new 3-chloro-pregnane derivatives
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
EP1275656A1 (en) * 2001-07-11 2003-01-15 Genchem Pharma Limited Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives
US7098328B2 (en) * 2001-11-29 2006-08-29 Taro Pharmaceutical Industries Limited Method for the preparation of 6α-fluoro corticosteroids
ATE318274T1 (de) * 2002-12-09 2006-03-15 Sicor Inc Prozess zur herstellung von 6 alpa-fluorierten pregnanen
WO2012011106A1 (en) 2010-07-20 2012-01-26 Taro Pharmaceutical Industries Ltd. Process for the preparation of 17-desoxy-corticosteroids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU75903A1 (US06534493-20030318-C00288.png) * 1976-09-29 1978-05-16
US3047596A (en) * 1959-11-17 1962-07-31 Merck & Co Inc 6alpha-halogen-9alpha-halogen-delta-pregnadiene-3-one compounds
SE339685B (US06534493-20030318-C00288.png) * 1967-06-16 1971-10-18 Warner Lambert Pharmaceutical
DE2365992C3 (de) * 1972-03-09 1982-05-19 The Upjohn Co., 49001 Kalamazoo, Mich. 6α-Fluor-17,21-dihydroxy-16β-methylpregna-4,9(11)-dien-3,20-dion-17,21-diacetat und Verfahren zu dessen Herstellung
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes

Also Published As

Publication number Publication date
US4255331A (en) 1981-03-10
PH16138A (en) 1983-07-08
FI66395C (fi) 1984-10-10
DE2913147A1 (de) 1979-10-18
GB2018258A (en) 1979-10-17
DE2913147C2 (US06534493-20030318-C00288.png) 1988-06-30
FI791124A (fi) 1979-10-06
FR2421914B1 (US06534493-20030318-C00288.png) 1983-07-22
FR2421914A1 (fr) 1979-11-02
NL7902333A (nl) 1979-10-09
JPS6425793A (en) 1989-01-27
NL187577C (nl) 1991-11-18
CH639655A5 (de) 1983-11-30
NL187577B (nl) 1991-06-17
JPH0217560B2 (US06534493-20030318-C00288.png) 1990-04-20
FI66395B (fi) 1984-06-29

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930404