GB2016271A - Producing gefarnate-containing solid preparations - Google Patents
Producing gefarnate-containing solid preparationsInfo
- Publication number
- GB2016271A GB2016271A GB7908723A GB7908723A GB2016271A GB 2016271 A GB2016271 A GB 2016271A GB 7908723 A GB7908723 A GB 7908723A GB 7908723 A GB7908723 A GB 7908723A GB 2016271 A GB2016271 A GB 2016271A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gefarnate
- containing solid
- producing
- pka
- solid preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A storage stable Gefarnate-containing solid preparation in which Gefarnate is absorbed on a basic solid carrier such as magnesium silicate, metamagnesium aluminosilicate, magnesium oxide, aluminium hydroxide gel or synthetic hydrotalcite, is obtained by treating the surface of the base with a pKa adjusting agent (other than a mono- or di- saccharide or sugar alcohol) such as citric acid, sodium citrate, polyvinyl alcohol or gum arabic, to bring its surface pKa to 9.3 or less (e.g. 3-8), and then absorbing the Gefarnate onto the treated carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53029746A JPS6026093B2 (en) | 1978-03-14 | 1978-03-14 | Method for producing gefalnate-containing solid preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2016271A true GB2016271A (en) | 1979-09-26 |
GB2016271B GB2016271B (en) | 1982-09-02 |
Family
ID=12284653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7908723A Expired GB2016271B (en) | 1978-03-14 | 1979-03-13 | Process for producing gefarnate-containing solid preparations |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS6026093B2 (en) |
AR (1) | AR218711A1 (en) |
BE (1) | BE874795A (en) |
CH (1) | CH637827A5 (en) |
CS (1) | CS207784B2 (en) |
ES (1) | ES478539A0 (en) |
FR (1) | FR2419729B1 (en) |
GB (1) | GB2016271B (en) |
HK (1) | HK49283A (en) |
IE (1) | IE48269B1 (en) |
IT (1) | IT1162282B (en) |
MT (1) | MTP843B (en) |
MX (1) | MX5996E (en) |
NL (1) | NL7901917A (en) |
PH (1) | PH16903A (en) |
PT (1) | PT69341A (en) |
ZA (1) | ZA791103B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2142235A (en) * | 1983-06-08 | 1985-01-16 | Thomae Gmbh Dr K | Oral antidiabetic pharmaceutical compositions |
US5516529A (en) * | 1989-04-07 | 1996-05-14 | Zellweger; Jean-Michel | Granulates useful for preparing effervescent pesticide tablets |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
JPS5635169B2 (en) * | 1974-02-14 | 1981-08-15 | ||
SE421042B (en) * | 1976-06-29 | 1981-11-23 | Kockums Chem | WANT TO REDUCE THE QUANTITY OF BIOLOGICAL ACTIVE SUBSTANCE REQUIRED FOR SOME BIOLOGICAL EFFECT |
JPS53148519A (en) * | 1977-05-31 | 1978-12-25 | Sumitomo Chem Co Ltd | Preparation of solid medicine containing gefarnate |
-
1978
- 1978-03-14 JP JP53029746A patent/JPS6026093B2/en not_active Expired
- 1978-08-25 PH PH21668A patent/PH16903A/en unknown
-
1979
- 1979-03-09 ZA ZA791103A patent/ZA791103B/en unknown
- 1979-03-09 AR AR275761D patent/AR218711A1/en active
- 1979-03-09 NL NL7901917A patent/NL7901917A/en not_active Application Discontinuation
- 1979-03-12 ES ES478539A patent/ES478539A0/en active Granted
- 1979-03-13 IT IT48332/79A patent/IT1162282B/en active
- 1979-03-13 CS CS791652A patent/CS207784B2/en unknown
- 1979-03-13 BE BE0/193985A patent/BE874795A/en not_active IP Right Cessation
- 1979-03-13 MX MX797810U patent/MX5996E/en unknown
- 1979-03-13 PT PT69341A patent/PT69341A/en unknown
- 1979-03-13 FR FR7906384A patent/FR2419729B1/en not_active Expired
- 1979-03-13 MT MT843A patent/MTP843B/en unknown
- 1979-03-13 GB GB7908723A patent/GB2016271B/en not_active Expired
- 1979-03-14 CH CH243379A patent/CH637827A5/en not_active IP Right Cessation
- 1979-08-08 IE IE725/79A patent/IE48269B1/en not_active IP Right Cessation
-
1983
- 1983-11-03 HK HK492/83A patent/HK49283A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2142235A (en) * | 1983-06-08 | 1985-01-16 | Thomae Gmbh Dr K | Oral antidiabetic pharmaceutical compositions |
US5516529A (en) * | 1989-04-07 | 1996-05-14 | Zellweger; Jean-Michel | Granulates useful for preparing effervescent pesticide tablets |
Also Published As
Publication number | Publication date |
---|---|
IT1162282B (en) | 1987-03-25 |
MX5996E (en) | 1984-09-18 |
MTP843B (en) | 1980-02-11 |
IT7948332A0 (en) | 1979-03-13 |
HK49283A (en) | 1983-11-11 |
JPS54122718A (en) | 1979-09-22 |
AR218711A1 (en) | 1980-06-30 |
CH637827A5 (en) | 1983-08-31 |
GB2016271B (en) | 1982-09-02 |
ES8200632A1 (en) | 1981-11-01 |
PH16903A (en) | 1984-04-10 |
IE790725L (en) | 1979-09-14 |
NL7901917A (en) | 1979-09-18 |
BE874795A (en) | 1979-07-02 |
FR2419729B1 (en) | 1988-07-08 |
PT69341A (en) | 1979-04-01 |
FR2419729A1 (en) | 1979-10-12 |
CS207784B2 (en) | 1981-08-31 |
IE48269B1 (en) | 1984-11-28 |
ZA791103B (en) | 1980-03-26 |
JPS6026093B2 (en) | 1985-06-21 |
ES478539A0 (en) | 1981-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940313 |