FR2419729A1 - METHOD OF MANUFACTURING SOLID PREPARATIONS CONTAINING GEFARNATE - Google Patents

METHOD OF MANUFACTURING SOLID PREPARATIONS CONTAINING GEFARNATE

Info

Publication number
FR2419729A1
FR2419729A1 FR7906384A FR7906384A FR2419729A1 FR 2419729 A1 FR2419729 A1 FR 2419729A1 FR 7906384 A FR7906384 A FR 7906384A FR 7906384 A FR7906384 A FR 7906384A FR 2419729 A1 FR2419729 A1 FR 2419729A1
Authority
FR
France
Prior art keywords
gefarnate
preparations containing
solid preparations
manufacturing solid
pka
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7906384A
Other languages
French (fr)
Other versions
FR2419729B1 (en
Inventor
Muneo Hara
Terutsugu Tsuji
Keiichi Matsuda
Tadashi Umezu
Munetoshi Adachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2419729A1 publication Critical patent/FR2419729A1/en
Application granted granted Critical
Publication of FR2419729B1 publication Critical patent/FR2419729B1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Le procédé consiste à faire absorber le Gefarnate dans une base solide qui peut être un silicate, l'oxyde de magnésium, un gel sec d'hydroxyde d'aluminium, etc, dont la surface a été traitée au préalable par un agent d'ajustement tel que l'acide citrique, l'alcool polyvinylique, la gomme arabique, etc., de façon à maintenir son pKa à 9,3 ou moins. Ce procédé est basé sur la découverte du fait que la décomposition du Gefarnate est favorisée lorsque le pKa de la surface est supérieur à 9,3. Le procédé permet d'obtenir une composition médicinale de Gefanate qui est très stable à la conservation.The process consists of absorbing the Gefarnate in a solid base which can be a silicate, magnesium oxide, a dry gel of aluminum hydroxide, etc., the surface of which has been previously treated with an adjusting agent. such as citric acid, polyvinyl alcohol, gum arabic, etc., so as to keep its pKa at 9.3 or less. This method is based on the discovery that the decomposition of Gefarnate is promoted when the pKa of the surface is greater than 9.3. The process results in a medicinal composition of Gefanate which is very stable on storage.

FR7906384A 1978-03-14 1979-03-13 PROCESS FOR PRODUCING SOLID PREPARATIONS CONTAINING GEFARNATE Expired FR2419729B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53029746A JPS6026093B2 (en) 1978-03-14 1978-03-14 Method for producing gefalnate-containing solid preparation

Publications (2)

Publication Number Publication Date
FR2419729A1 true FR2419729A1 (en) 1979-10-12
FR2419729B1 FR2419729B1 (en) 1988-07-08

Family

ID=12284653

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7906384A Expired FR2419729B1 (en) 1978-03-14 1979-03-13 PROCESS FOR PRODUCING SOLID PREPARATIONS CONTAINING GEFARNATE

Country Status (17)

Country Link
JP (1) JPS6026093B2 (en)
AR (1) AR218711A1 (en)
BE (1) BE874795A (en)
CH (1) CH637827A5 (en)
CS (1) CS207784B2 (en)
ES (1) ES478539A0 (en)
FR (1) FR2419729B1 (en)
GB (1) GB2016271B (en)
HK (1) HK49283A (en)
IE (1) IE48269B1 (en)
IT (1) IT1162282B (en)
MT (1) MTP843B (en)
MX (1) MX5996E (en)
NL (1) NL7901917A (en)
PH (1) PH16903A (en)
PT (1) PT69341A (en)
ZA (1) ZA791103B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3320583A1 (en) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach NEW GALENIC PREPARATION FORMS OF ORAL ANTIDIABETICS AND METHOD FOR THE PRODUCTION THEREOF
ES2055894T3 (en) * 1989-04-07 1994-09-01 Ciba Geigy Ag CONCENTRATES OF PESTICIDED ACTIVE SUBSTANCES AND THEIR PREPARATION.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467976A1 (en) * 1963-09-18 1969-01-16 Key Pharma Carriers for pharmaceuticals and processes for their manufacture
JPS50126821A (en) * 1974-02-14 1975-10-06
LU76238A1 (en) * 1976-06-29 1977-05-23
JPS53148519A (en) * 1977-05-31 1978-12-25 Sumitomo Chem Co Ltd Preparation of solid medicine containing gefarnate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467976A1 (en) * 1963-09-18 1969-01-16 Key Pharma Carriers for pharmaceuticals and processes for their manufacture
JPS50126821A (en) * 1974-02-14 1975-10-06
LU76238A1 (en) * 1976-06-29 1977-05-23
JPS53148519A (en) * 1977-05-31 1978-12-25 Sumitomo Chem Co Ltd Preparation of solid medicine containing gefarnate

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CA1976 *
CA1978 *
DW1979 *

Also Published As

Publication number Publication date
CS207784B2 (en) 1981-08-31
ES8200632A1 (en) 1981-11-01
PH16903A (en) 1984-04-10
JPS54122718A (en) 1979-09-22
FR2419729B1 (en) 1988-07-08
NL7901917A (en) 1979-09-18
ES478539A0 (en) 1981-11-01
AR218711A1 (en) 1980-06-30
ZA791103B (en) 1980-03-26
HK49283A (en) 1983-11-11
CH637827A5 (en) 1983-08-31
MX5996E (en) 1984-09-18
GB2016271B (en) 1982-09-02
IT1162282B (en) 1987-03-25
MTP843B (en) 1980-02-11
GB2016271A (en) 1979-09-26
BE874795A (en) 1979-07-02
IE790725L (en) 1979-09-14
JPS6026093B2 (en) 1985-06-21
PT69341A (en) 1979-04-01
IE48269B1 (en) 1984-11-28
IT7948332A0 (en) 1979-03-13

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TP Transmission of property
TP Transmission of property
ST Notification of lapse