ES8200632A1 - Producing gefarnate-containing solid preparations - Google Patents
Producing gefarnate-containing solid preparationsInfo
- Publication number
- ES8200632A1 ES8200632A1 ES478539A ES478539A ES8200632A1 ES 8200632 A1 ES8200632 A1 ES 8200632A1 ES 478539 A ES478539 A ES 478539A ES 478539 A ES478539 A ES 478539A ES 8200632 A1 ES8200632 A1 ES 8200632A1
- Authority
- ES
- Spain
- Prior art keywords
- gefarnate
- containing solid
- producing
- pka
- solid preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZPACYDRSPFRDHO-ROBAGEODSA-N Gefarnate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(=O)OC\C=C(/C)CCC=C(C)C ZPACYDRSPFRDHO-ROBAGEODSA-N 0.000 title abstract 4
- 229920001386 Gefarnate Polymers 0.000 title abstract 4
- 229960003779 gefarnate Drugs 0.000 title abstract 4
- 239000007787 solid Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- 241000978776 Senegalia senegal Species 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001545 hydrotalcite Drugs 0.000 abstract 1
- 229910001701 hydrotalcite Inorganic materials 0.000 abstract 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229910052919 magnesium silicate Inorganic materials 0.000 abstract 1
- 235000019792 magnesium silicate Nutrition 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A storage stable Gefarnate-containing solid preparation in which Gefarnate is absorbed on a basic solid carrier such as magnesium silicate, metamagnesium aluminosilicate, magnesium oxide, aluminium hydroxide gel or synthetic hydrotalcite, is obtained by treating the surface of the base with a pKa adjusting agent (other than a mono- or di- saccharide or sugar alcohol) such as citric acid, sodium citrate, polyvinyl alcohol or gum arabic, to bring its surface pKa to 9.3 or less (e.g. 3-8), and then absorbing the Gefarnate onto the treated carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53029746A JPS6026093B2 (en) | 1978-03-14 | 1978-03-14 | Method for producing gefalnate-containing solid preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES478539A0 ES478539A0 (en) | 1981-11-01 |
| ES8200632A1 true ES8200632A1 (en) | 1981-11-01 |
Family
ID=12284653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478539A Expired ES8200632A1 (en) | 1978-03-14 | 1979-03-12 | Producing gefarnate-containing solid preparations |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS6026093B2 (en) |
| AR (1) | AR218711A1 (en) |
| BE (1) | BE874795A (en) |
| CH (1) | CH637827A5 (en) |
| CS (1) | CS207784B2 (en) |
| ES (1) | ES8200632A1 (en) |
| FR (1) | FR2419729B1 (en) |
| GB (1) | GB2016271B (en) |
| HK (1) | HK49283A (en) |
| IE (1) | IE48269B1 (en) |
| IT (1) | IT1162282B (en) |
| MT (1) | MTP843B (en) |
| MX (1) | MX5996E (en) |
| NL (1) | NL7901917A (en) |
| PH (1) | PH16903A (en) |
| PT (1) | PT69341A (en) |
| ZA (1) | ZA791103B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3320583A1 (en) * | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW GALENIC PREPARATION FORMS OF ORAL ANTIDIABETICS AND METHOD FOR THE PRODUCTION THEREOF |
| ES2055894T3 (en) * | 1989-04-07 | 1994-09-01 | Ciba Geigy Ag | CONCENTRATES OF PESTICIDED ACTIVE SUBSTANCES AND THEIR PREPARATION. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
| JPS5635169B2 (en) * | 1974-02-14 | 1981-08-15 | ||
| SE421042B (en) * | 1976-06-29 | 1981-11-23 | Kockums Chem | WANT TO REDUCE THE QUANTITY OF BIOLOGICAL ACTIVE SUBSTANCE REQUIRED FOR SOME BIOLOGICAL EFFECT |
| JPS53148519A (en) * | 1977-05-31 | 1978-12-25 | Sumitomo Chem Co Ltd | Preparation of solid medicine containing gefarnate |
-
1978
- 1978-03-14 JP JP53029746A patent/JPS6026093B2/en not_active Expired
- 1978-08-25 PH PH21668A patent/PH16903A/en unknown
-
1979
- 1979-03-09 ZA ZA791103A patent/ZA791103B/en unknown
- 1979-03-09 NL NL7901917A patent/NL7901917A/en not_active Application Discontinuation
- 1979-03-09 AR AR275761D patent/AR218711A1/en active
- 1979-03-12 ES ES478539A patent/ES8200632A1/en not_active Expired
- 1979-03-13 IT IT48332/79A patent/IT1162282B/en active
- 1979-03-13 CS CS791652A patent/CS207784B2/en unknown
- 1979-03-13 MX MX797810U patent/MX5996E/en unknown
- 1979-03-13 BE BE0/193985A patent/BE874795A/en not_active IP Right Cessation
- 1979-03-13 MT MT843A patent/MTP843B/en unknown
- 1979-03-13 GB GB7908723A patent/GB2016271B/en not_active Expired
- 1979-03-13 PT PT69341A patent/PT69341A/en unknown
- 1979-03-13 FR FR7906384A patent/FR2419729B1/en not_active Expired
- 1979-03-14 CH CH243379A patent/CH637827A5/en not_active IP Right Cessation
- 1979-08-08 IE IE725/79A patent/IE48269B1/en not_active IP Right Cessation
-
1983
- 1983-11-03 HK HK492/83A patent/HK49283A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH16903A (en) | 1984-04-10 |
| ES478539A0 (en) | 1981-11-01 |
| IT1162282B (en) | 1987-03-25 |
| JPS54122718A (en) | 1979-09-22 |
| MTP843B (en) | 1980-02-11 |
| HK49283A (en) | 1983-11-11 |
| GB2016271A (en) | 1979-09-26 |
| MX5996E (en) | 1984-09-18 |
| JPS6026093B2 (en) | 1985-06-21 |
| IT7948332A0 (en) | 1979-03-13 |
| PT69341A (en) | 1979-04-01 |
| IE790725L (en) | 1979-09-14 |
| CH637827A5 (en) | 1983-08-31 |
| BE874795A (en) | 1979-07-02 |
| NL7901917A (en) | 1979-09-18 |
| GB2016271B (en) | 1982-09-02 |
| IE48269B1 (en) | 1984-11-28 |
| FR2419729B1 (en) | 1988-07-08 |
| ZA791103B (en) | 1980-03-26 |
| FR2419729A1 (en) | 1979-10-12 |
| AR218711A1 (en) | 1980-06-30 |
| CS207784B2 (en) | 1981-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |