GB201603779D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
GB201603779D0
GB201603779D0 GBGB1603779.8A GB201603779A GB201603779D0 GB 201603779 D0 GB201603779 D0 GB 201603779D0 GB 201603779 A GB201603779 A GB 201603779A GB 201603779 D0 GB201603779 D0 GB 201603779D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1603779.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mission Therapeutics Ltd
Original Assignee
Mission Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mission Therapeutics Ltd filed Critical Mission Therapeutics Ltd
Priority to GBGB1603779.8A priority Critical patent/GB201603779D0/en
Publication of GB201603779D0 publication Critical patent/GB201603779D0/en
Priority to CA3016370A priority patent/CA3016370C/en
Priority to SG11201807301SA priority patent/SG11201807301SA/en
Priority to MX2018008271A priority patent/MX382562B/es
Priority to KR1020187028269A priority patent/KR102384139B1/ko
Priority to PCT/GB2017/050565 priority patent/WO2017149313A1/en
Priority to MA043701A priority patent/MA43701A/fr
Priority to RU2018133279A priority patent/RU2730552C2/ru
Priority to NZ746531A priority patent/NZ746531B2/en
Priority to EP17709766.4A priority patent/EP3423454B1/en
Priority to JP2018546518A priority patent/JP6959247B2/ja
Priority to HK19100946.4A priority patent/HK1258589B/xx
Priority to AU2017225371A priority patent/AU2017225371B2/en
Priority to MYPI2018001499A priority patent/MY196836A/en
Priority to EP22172828.0A priority patent/EP4067355A1/en
Priority to CN201780010388.5A priority patent/CN108602823B/zh
Priority to BR112018017086-0A priority patent/BR112018017086B1/pt
Priority to US16/078,518 priority patent/US10654853B2/en
Priority to ES17709766T priority patent/ES2919549T3/es
Priority to ZA2018/03910A priority patent/ZA201803910B/en
Priority to IL261552A priority patent/IL261552B/en
Priority to CONC2018/0009275A priority patent/CO2018009275A2/es
Priority to US16/843,408 priority patent/US11236092B2/en
Priority to JP2021158986A priority patent/JP7280928B2/ja
Priority to US17/550,071 priority patent/US20220106315A1/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GBGB1603779.8A 2016-03-04 2016-03-04 Novel compounds Ceased GB201603779D0 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GBGB1603779.8A GB201603779D0 (en) 2016-03-04 2016-03-04 Novel compounds
ES17709766T ES2919549T3 (es) 2016-03-04 2017-03-02 Derivados de pirrolidina condensados en espiro como inhibidores de enzimas desubiquitinantes (dub)
AU2017225371A AU2017225371B2 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
EP22172828.0A EP4067355A1 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzyme (dub) inhibitors
MX2018008271A MX382562B (es) 2016-03-04 2017-03-02 Derivados pirrolidina espiro-condensados como inhibidores de enzimas desubiquitinantes (dub).
KR1020187028269A KR102384139B1 (ko) 2016-03-04 2017-03-02 탈유비퀴틴화 효소(dub) 억제제로서 스피로-축합된 피롤리딘 유도체
PCT/GB2017/050565 WO2017149313A1 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
MA043701A MA43701A (fr) 2016-03-04 2017-03-02 Dérivés de pyrrolidine spiro-fusionnés en tant qu'inhibiteurs des enzymes de désubiquitination (dub)
RU2018133279A RU2730552C2 (ru) 2016-03-04 2017-03-02 Спироконденсированные пирролидиновые производные в качестве ингибиторов деубиквитилирующих ферментов (DUB)
NZ746531A NZ746531B2 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
EP17709766.4A EP3423454B1 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
JP2018546518A JP6959247B2 (ja) 2016-03-04 2017-03-02 脱ユビキチン化酵素(dub)阻害剤としてのスピロ縮合ピロリジン誘導体
HK19100946.4A HK1258589B (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
CA3016370A CA3016370C (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
MYPI2018001499A MY196836A (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
SG11201807301SA SG11201807301SA (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
CN201780010388.5A CN108602823B (zh) 2016-03-04 2017-03-02 作为去泛素化酶(dub)抑制剂的螺-缩合吡咯烷衍生物
BR112018017086-0A BR112018017086B1 (pt) 2016-03-04 2017-03-02 Derivados de pirrolidina espiro-condensada, composição compreendendo o referido composto e seu uso
US16/078,518 US10654853B2 (en) 2016-03-04 2017-03-02 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
ZA2018/03910A ZA201803910B (en) 2016-03-04 2018-06-12 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
IL261552A IL261552B (en) 2016-03-04 2018-09-02 Spiro-condensed pyrrolidine derivatives that inhibit deubiquitination enzymes (dub)
CONC2018/0009275A CO2018009275A2 (es) 2016-03-04 2018-09-04 Derivados pirrolidina espiro-condensados como inhibidores de enzimas desubiquitinantes (dub)
US16/843,408 US11236092B2 (en) 2016-03-04 2020-04-08 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
JP2021158986A JP7280928B2 (ja) 2016-03-04 2021-09-29 脱ユビキチン化酵素(dub)阻害剤としてのスピロ縮合ピロリジン誘導体
US17/550,071 US20220106315A1 (en) 2016-03-04 2021-12-14 Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1603779.8A GB201603779D0 (en) 2016-03-04 2016-03-04 Novel compounds

Publications (1)

Publication Number Publication Date
GB201603779D0 true GB201603779D0 (en) 2016-04-20

Family

ID=55859019

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1603779.8A Ceased GB201603779D0 (en) 2016-03-04 2016-03-04 Novel compounds

Country Status (19)

Country Link
US (3) US10654853B2 (https=)
EP (2) EP4067355A1 (https=)
JP (2) JP6959247B2 (https=)
KR (1) KR102384139B1 (https=)
CN (1) CN108602823B (https=)
AU (1) AU2017225371B2 (https=)
BR (1) BR112018017086B1 (https=)
CA (1) CA3016370C (https=)
CO (1) CO2018009275A2 (https=)
ES (1) ES2919549T3 (https=)
GB (1) GB201603779D0 (https=)
IL (1) IL261552B (https=)
MA (1) MA43701A (https=)
MX (1) MX382562B (https=)
MY (1) MY196836A (https=)
RU (1) RU2730552C2 (https=)
SG (1) SG11201807301SA (https=)
WO (1) WO2017149313A1 (https=)
ZA (1) ZA201803910B (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX373656B (es) 2015-03-30 2020-04-02 Mission Therapeutics Ltd Compuestos de 1-ciano-pirrolidina como inhibidores de las enzimas desubiquitinantes, como la hidrolasa 30 de la c-terminal de la ubiquitina (usp30), y el uso de los mismos en el tratamiento de condiciones de disfunción mitocondrial y tratamiento de cancér.
US10669234B2 (en) 2015-07-14 2020-06-02 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
GB201521109D0 (en) 2015-11-30 2016-01-13 Mission Therapeutics Ltd Novel compounds
GB201522267D0 (en) 2015-12-17 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201522768D0 (en) 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201602854D0 (en) 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
GB201603779D0 (en) * 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
GB201604647D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
GB201604638D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
JP6959252B2 (ja) 2016-03-24 2021-11-02 ミッション セラピューティクス リミティド Dub阻害剤としての1−シアノピロリジン誘導体
ES2850349T3 (es) 2016-09-27 2021-08-27 Mission Therapeutics Ltd Derivados de cianopirrolidina con actividad como inhibidores de USP30
GB201616511D0 (en) 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
GB201616627D0 (en) 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
TWI771327B (zh) 2016-10-05 2022-07-21 英商使命醫療公司 新穎化合物
GB201708652D0 (en) 2017-05-31 2017-07-12 Mission Therapeutics Ltd Novel compounds and uses
JP7208931B2 (ja) 2017-06-20 2023-01-19 ミッション セラピューティクス リミティド Dub阻害剤としての活性をもつ置換シアノピロリジン類
BR112020003725A2 (pt) 2017-10-06 2020-11-03 Forma Therapeutics, Inc. inibição da peptidase 30 específica de ubiquitina
JP7449242B2 (ja) 2018-05-17 2024-03-13 フォーマ セラピューティクス,インコーポレイテッド ユビキチン特異的ペプチダーゼ30(usp30)阻害剤として有用な縮合二環化合物
JP7434285B2 (ja) 2018-08-14 2024-02-20 アムジエン・インコーポレーテツド N-シアノ-7-アザノルボルナン誘導体及びその使用
LT3860989T (lt) 2018-10-05 2023-06-12 Forma Therapeutics, Inc. Sulieti pirolinai, kurie veikia kaip ubikvitinui specifinės proteazės 30 (ups30) inhibitoriai
GB201905371D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
GB201905375D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
GB201912674D0 (en) 2019-09-04 2019-10-16 Mission Therapeutics Ltd Novel compounds
WO2021204856A1 (en) 2020-04-08 2021-10-14 Mission Therapeutics Limited N-cyanopyrrolidines with activity as usp30 inhibitors
IL298526A (en) 2020-05-28 2023-01-01 Mission Therapeutics Ltd N-(1-cyano-pyrrolidin-3-yl)-5-(3-(trifluoromethyl)phenyl)oxazole-2-carboxamide derivatives and the corresponding oxadiazole derivatives as usp30 inhibitors for the treatment of mitochondrial dysfunction
BR112022019722A2 (pt) 2020-06-04 2022-12-20 Mission Therapeutics Ltd N-cianopirrolidinas com atividade como inibidores de usp30
DK4161929T3 (da) 2020-06-08 2025-08-18 Mission Therapeutics Ltd 1-(5-(2-cyanopyridin-4-yl)oxazol-2-carbonyl)-4-methylhexahydropyrrolo[3,4-b]pyrrol-5(1h)-carbonitril som usp30-hæmmer til anvendelse i behandling af mitokondriedysfunktion, cancer og fibrose
GB202016800D0 (en) 2020-10-22 2020-12-09 Mission Therapeutics Ltd Novel compounds
CN116143782B (zh) * 2021-11-22 2024-04-12 西南大学 一类螺[吡咯烷-2,3'-喹啉]-2'-酮类衍生物的设计合成与应用
US20250034122A1 (en) 2021-12-01 2025-01-30 Mission Therapeutics Limited Substituted n-cyanopyrrolidines with activity as usp30 inhibitors
MX2024007932A (es) * 2021-12-23 2024-09-18 Univ Leuven Kath Spiros y analogos relacionados para inhibir yap/taz-tead.
WO2024151847A1 (en) * 2023-01-13 2024-07-18 The University Of North Carolina At Chapel Hill Identification of otud7b inhibitor 7bi and its application in reducing growth of nsclc and leukemia cells
GB202408928D0 (en) 2024-06-21 2024-08-07 Mission Therapeutics Ltd Novel compounds
GB202411060D0 (en) 2024-07-29 2024-09-11 Mission Therapeutics Ltd Novel compounds

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SG176463A1 (en) 2005-02-22 2011-12-29 Univ Michigan Small molecule inhibitors of mdm2 and uses thereof
SG174107A1 (en) * 2006-08-30 2011-09-29 Univ Michigan New small molecule inhibitors of mdm2 and the uses thereof
WO2008144507A2 (en) 2007-05-16 2008-11-27 President And Fellows Of Harvard College Spirooxindole inhibitors of aurora kinase
PE20090606A1 (es) * 2007-08-20 2009-06-17 Glaxo Group Ltd Nuevos inhibidores de catepsina c y uso
US8088815B2 (en) * 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
GB0922589D0 (en) 2009-12-23 2010-02-10 Almac Discovery Ltd Pharmaceutical compounds
AU2012226890B2 (en) 2011-03-10 2016-10-06 Daiichi Sankyo Company, Limited Dispiropyrrolidine derivative
EP2752191A1 (en) 2013-01-07 2014-07-09 Sanofi Compositions and methods using hdm2 antagonist and mek inhibitor
GB201416754D0 (en) * 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
MX373656B (es) 2015-03-30 2020-04-02 Mission Therapeutics Ltd Compuestos de 1-ciano-pirrolidina como inhibidores de las enzimas desubiquitinantes, como la hidrolasa 30 de la c-terminal de la ubiquitina (usp30), y el uso de los mismos en el tratamiento de condiciones de disfunción mitocondrial y tratamiento de cancér.
US10669234B2 (en) * 2015-07-14 2020-06-02 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
GB201521109D0 (en) 2015-11-30 2016-01-13 Mission Therapeutics Ltd Novel compounds
GB201522267D0 (en) 2015-12-17 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201522768D0 (en) 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
GB201603779D0 (en) 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
GB201604647D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
GB201604638D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
JP6959252B2 (ja) 2016-03-24 2021-11-02 ミッション セラピューティクス リミティド Dub阻害剤としての1−シアノピロリジン誘導体
ES2850349T3 (es) 2016-09-27 2021-08-27 Mission Therapeutics Ltd Derivados de cianopirrolidina con actividad como inhibidores de USP30
GB201616511D0 (en) 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
GB201616627D0 (en) 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
TWI771327B (zh) 2016-10-05 2022-07-21 英商使命醫療公司 新穎化合物

Also Published As

Publication number Publication date
JP2021193144A (ja) 2021-12-23
SG11201807301SA (en) 2018-09-27
US11236092B2 (en) 2022-02-01
KR20180119644A (ko) 2018-11-02
EP3423454B1 (en) 2022-05-25
IL261552A (en) 2018-10-31
CO2018009275A2 (es) 2018-10-10
US20200247803A1 (en) 2020-08-06
MY196836A (en) 2023-05-03
NZ746531A (en) 2022-03-25
AU2017225371A1 (en) 2018-10-11
WO2017149313A1 (en) 2017-09-08
RU2730552C2 (ru) 2020-08-24
US10654853B2 (en) 2020-05-19
JP6959247B2 (ja) 2021-11-02
MX382562B (es) 2025-03-13
ZA201803910B (en) 2020-01-29
MA43701A (fr) 2018-11-28
BR112018017086B1 (pt) 2024-02-20
ES2919549T3 (es) 2022-07-27
US20190048008A1 (en) 2019-02-14
RU2018133279A3 (https=) 2020-04-06
HK1258589A1 (zh) 2019-11-15
BR112018017086A2 (pt) 2019-01-02
CN108602823B (zh) 2022-04-01
EP4067355A1 (en) 2022-10-05
IL261552B (en) 2021-03-25
RU2018133279A (ru) 2020-04-06
CA3016370C (en) 2023-08-01
CA3016370A1 (en) 2017-09-08
EP3423454A1 (en) 2019-01-09
KR102384139B1 (ko) 2022-04-07
AU2017225371B2 (en) 2020-07-02
US20220106315A1 (en) 2022-04-07
CN108602823A (zh) 2018-09-28
JP2019507177A (ja) 2019-03-14
JP7280928B2 (ja) 2023-05-24

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