GB201418965D0 - - Google Patents
Info
- Publication number
- GB201418965D0 GB201418965D0 GBGB1418965.8A GB201418965A GB201418965D0 GB 201418965 D0 GB201418965 D0 GB 201418965D0 GB 201418965 A GB201418965 A GB 201418965A GB 201418965 D0 GB201418965 D0 GB 201418965D0
- Authority
- GB
- United Kingdom
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01037—DNA (cytosine-5-)-methyltransferase (2.1.1.37)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1418965.8A GB201418965D0 (OSRAM) | 2014-10-24 | 2014-10-24 | |
| PCT/IB2015/058202 WO2016063264A1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
| PL15794644T PL3209783T3 (pl) | 2014-10-24 | 2015-10-23 | Trwałe epigenetyczne wyciszanie genu |
| EP21197502.4A EP3995584A1 (en) | 2014-10-24 | 2015-10-23 | Gene silencing |
| AU2015334469A AU2015334469B2 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
| ES15794644T ES2906263T3 (es) | 2014-10-24 | 2015-10-23 | Silenciamiento génico epigénico permanente |
| EP15794644.3A EP3209783B1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
| DK15794644.3T DK3209783T3 (da) | 2014-10-24 | 2015-10-23 | Permanent epigenetisk gen-inaktivering (gene silencing) |
| CA2965591A CA2965591A1 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
| PT157946443T PT3209783T (pt) | 2014-10-24 | 2015-10-23 | Silenciamento de genes epigenético permanente |
| JP2017522083A JP7002936B2 (ja) | 2014-10-24 | 2015-10-23 | 持続的エピジェネティック遺伝子サイレンシング |
| US15/521,294 US12152240B2 (en) | 2014-10-24 | 2015-10-23 | Permanent epigenetic gene silencing |
| CN202211663401.6A CN116789846A (zh) | 2014-10-24 | 2015-10-23 | 永久性表观遗传基因沉默 |
| CN201580057762.8A CN107109433B (zh) | 2014-10-24 | 2015-10-23 | 永久性表观遗传基因沉默 |
| HUE15794644A HUE057846T2 (hu) | 2014-10-24 | 2015-10-23 | Permanens epigenetikus géncsendesítés |
| JP2021213691A JP7623272B2 (ja) | 2014-10-24 | 2021-12-28 | 持続的エピジェネティック遺伝子サイレンシング |
| AU2022202407A AU2022202407B2 (en) | 2014-10-24 | 2022-04-12 | Permanent epigenetic gene silencing |
| US18/920,508 US20250236870A1 (en) | 2014-10-24 | 2024-10-18 | Permanent epigenetic gene silencing |
| JP2025005873A JP2025063201A (ja) | 2014-10-24 | 2025-01-16 | 持続的エピジェネティック遺伝子サイレンシング |
| AU2025201007A AU2025201007A1 (en) | 2014-10-24 | 2025-02-13 | Permanent epigenetic gene silencing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1418965.8A GB201418965D0 (OSRAM) | 2014-10-24 | 2014-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201418965D0 true GB201418965D0 (OSRAM) | 2014-12-10 |
Family
ID=52103358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB1418965.8A Ceased GB201418965D0 (OSRAM) | 2014-10-24 | 2014-10-24 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12152240B2 (OSRAM) |
| EP (2) | EP3995584A1 (OSRAM) |
| JP (3) | JP7002936B2 (OSRAM) |
| CN (2) | CN116789846A (OSRAM) |
| AU (3) | AU2015334469B2 (OSRAM) |
| CA (1) | CA2965591A1 (OSRAM) |
| DK (1) | DK3209783T3 (OSRAM) |
| ES (1) | ES2906263T3 (OSRAM) |
| GB (1) | GB201418965D0 (OSRAM) |
| HU (1) | HUE057846T2 (OSRAM) |
| PL (1) | PL3209783T3 (OSRAM) |
| PT (1) | PT3209783T (OSRAM) |
| WO (1) | WO2016063264A1 (OSRAM) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163628A2 (en) | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| GB201418965D0 (OSRAM) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| EP3215623A4 (en) * | 2014-11-06 | 2018-09-26 | President and Fellows of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| EP4269601A3 (en) * | 2015-03-27 | 2024-01-10 | President and Fellows of Harvard College | Modified t cells and methods of making and using the same |
| US11674144B2 (en) * | 2015-04-16 | 2023-06-13 | California Institute Of Technology | Fractional regulation of transcription |
| AU2016261600B2 (en) | 2015-05-08 | 2021-09-23 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| EP3384055B1 (en) | 2015-11-30 | 2025-07-16 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| HK1257295A1 (zh) | 2015-12-04 | 2019-10-18 | Novartis Ag | 用於免疫肿瘤学的组合物和方法 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| EP3463484A4 (en) * | 2016-05-27 | 2019-10-30 | The Regents of the University of California | METHOD AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS AT SPECIFIC LOCI |
| US20190100732A1 (en) * | 2016-06-02 | 2019-04-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
| EP3487523B1 (en) | 2016-07-19 | 2023-09-06 | Duke University | Therapeutic applications of cpf1-based genome editing |
| CA3034369A1 (en) | 2016-08-19 | 2018-02-22 | Whitehead Institute For Biomedical Research | Methods of editing dna methylation |
| EP3510152A4 (en) | 2016-09-07 | 2020-04-29 | Flagship Pioneering, Inc. | METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION |
| WO2018111944A1 (en) | 2016-12-12 | 2018-06-21 | Whitehead Institute For Biomedical Research | Regulation of transcription through ctcf loop anchors |
| US11873496B2 (en) | 2017-01-09 | 2024-01-16 | Whitehead Institute For Biomedical Research | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
| WO2018160908A1 (en) * | 2017-03-03 | 2018-09-07 | Flagship Pioneering, Inc. | Methods and systems for modifying dna |
| EP3601561A2 (en) | 2017-03-22 | 2020-02-05 | Novartis AG | Compositions and methods for immunooncology |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| JP7356354B2 (ja) | 2017-05-12 | 2023-10-04 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 細胞の操作のための材料及び方法並びに免疫腫瘍学におけるその使用 |
| US11072782B2 (en) | 2017-07-24 | 2021-07-27 | Albert-Ludwigs-Universitaet Freiburg | Construct for epigenetic modification and its use in the silencing of genes |
| CN107759673B (zh) * | 2017-09-27 | 2021-06-04 | 复旦大学 | 可对hbv的dna进行表观甲基化修饰的蛋白分子及其应用 |
| US11629342B2 (en) | 2017-10-17 | 2023-04-18 | President And Fellows Of Harvard College | Cas9-based transcription modulation systems |
| WO2019204766A1 (en) * | 2018-04-19 | 2019-10-24 | The Regents Of The University Of California | Compositions and methods for gene editing |
| SG11202011080QA (en) | 2018-05-11 | 2020-12-30 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
| WO2020057666A1 (zh) * | 2018-09-21 | 2020-03-26 | 科济生物医药(上海)有限公司 | 表达有嵌合受体的t细胞 |
| GB201817821D0 (en) * | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| US12428639B2 (en) | 2019-03-05 | 2025-09-30 | Ramot At Tel-Aviv University Ltd. | Plant DNA methyltransferases and uses thereof |
| SG11202111443SA (en) | 2019-04-23 | 2021-11-29 | Sangamo Therapeutics Inc | Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof |
| JP2022531185A (ja) | 2019-04-30 | 2022-07-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 遺伝子改変t細胞を標的化するcd19を使用するb細胞悪性病変の同種細胞療法 |
| CN114729376A (zh) | 2019-09-23 | 2022-07-08 | 欧米茄治疗公司 | 用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法 |
| WO2021095012A1 (en) * | 2019-11-13 | 2021-05-20 | Crispr Therapeutics Ag | Methods of manufacturing car-t cells |
| AR120469A1 (es) * | 2019-11-13 | 2022-02-16 | Crispr Therapeutics Ag | Proceso de fabricación para hacer células t que expresen receptores de antígeno quiméricos |
| US20230399640A1 (en) * | 2020-09-24 | 2023-12-14 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for inhibiting gene expression |
| IL303923A (en) * | 2020-12-22 | 2023-08-01 | Chroma Medicine Inc | Compositions and methods for epigenetic editing |
| JP2024506751A (ja) * | 2021-02-01 | 2024-02-14 | イプシレン バイオ エス.アール.エル. | 遺伝子サイレンシング |
| US20240101623A1 (en) * | 2021-02-15 | 2024-03-28 | Ospedale San Raffaele S.R.L. | Epigenetic silencing for treatment of cancer |
| CN115247175B (zh) * | 2021-11-25 | 2025-10-17 | 南京启真基因工程有限公司 | 构建setdb1基因突变的表观遗传失调模型猪核移植供体细胞的基因编辑系统及其应用 |
| WO2023165597A1 (en) * | 2022-03-04 | 2023-09-07 | Epigenic Therapeutics , Inc. | Compositions and methods of genome editing |
| JP2025525389A (ja) * | 2022-06-23 | 2025-08-05 | エヌクロマ・バイオ,インコーポレーテッド | Ciita発現のエピジェネティック調節のための組成物及び方法 |
| WO2023250490A1 (en) * | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of trac expression |
| IL317913A (en) * | 2022-06-23 | 2025-02-01 | Chroma Medicine Inc | Compositions and methods for epigenetic regulation of B2M expression |
| EP4543908A1 (en) | 2022-06-23 | 2025-04-30 | nChroma Bio, Inc. | Compositions and methods for epigenetic editing |
| CN119731321A (zh) | 2022-06-24 | 2025-03-28 | 图恩疗法股份有限公司 | 通过靶向基因阻遏减少低密度脂蛋白的组合物、系统和方法 |
| US12221608B2 (en) | 2022-08-19 | 2025-02-11 | Tune Therapeutics, Inc. | Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression |
| EP4590822A1 (en) * | 2022-09-23 | 2025-07-30 | nChroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024081879A1 (en) * | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| US12252715B2 (en) | 2023-02-17 | 2025-03-18 | Whitehead Institute For Biomedical Research | Compositions and methods for making epigenetic modifications |
| WO2024220857A1 (en) * | 2023-04-20 | 2024-10-24 | Chroma Medicine, Inc. | Fusion proteins for epigenetic regulation |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024238700A1 (en) * | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| IT202300011790A1 (it) | 2023-06-08 | 2024-12-08 | Fond Telethon Ets | Protocolli di manipolazione genica in cellule immunitarie |
| CN119464241A (zh) * | 2023-08-09 | 2025-02-18 | 厦门大学 | 瓜氨酸化setdb1多肽及其在诊断类风湿性关节炎中的应用 |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
Family Cites Families (56)
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| PT3209783T (pt) | 2022-02-10 |
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| EP3209783A1 (en) | 2017-08-30 |
| ES2906263T3 (es) | 2022-04-13 |
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| AU2015334469A1 (en) | 2017-05-25 |
| JP2017537611A (ja) | 2017-12-21 |
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| CN116789846A (zh) | 2023-09-22 |
| WO2016063264A1 (en) | 2016-04-28 |
| EP3209783B1 (en) | 2021-11-24 |
| JP7623272B2 (ja) | 2025-01-28 |
| AU2015334469B2 (en) | 2022-01-20 |
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| CN107109433A (zh) | 2017-08-29 |
| PL3209783T3 (pl) | 2022-04-19 |
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| CA2965591A1 (en) | 2016-04-28 |
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