GB201118656D0 - New compounds - Google Patents
New compoundsInfo
- Publication number
- GB201118656D0 GB201118656D0 GBGB1118656.6A GB201118656A GB201118656D0 GB 201118656 D0 GB201118656 D0 GB 201118656D0 GB 201118656 A GB201118656 A GB 201118656A GB 201118656 D0 GB201118656 D0 GB 201118656D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- new compounds
- cancer
- diseases
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1118656.6A GB201118656D0 (en) | 2011-10-28 | 2011-10-28 | New compounds |
JOP/2012/0308A JO3419B1 (ar) | 2011-10-28 | 2012-10-15 | مركبات بيريدوبيرازين مضادة للسرطان من خلال تثبيط إنزيمات كيناز fgfr |
TW101139220A TWI602814B (zh) | 2011-10-28 | 2012-10-24 | 透過抑制fgfr激酶之具有抗癌性的吡啶並吡嗪衍生物化合物 |
DK12794745.5T DK2776435T3 (en) | 2011-10-28 | 2012-10-26 | ANTICANCER PYRIDOPYRAZINES BY INHIBITION OF FGFR KINASES |
MYPI2014001207A MY185666A (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
CN201280065190.4A CN104011051B (zh) | 2011-10-28 | 2012-10-26 | 通过fgfr激酶抑制抗癌的吡啶并吡嗪 |
UAA201405742A UA111386C2 (uk) | 2011-10-28 | 2012-10-26 | Піридопіразини, які мають протиракову активність через інгібування fgfr-кіназ |
MX2014004855A MX353654B (es) | 2011-10-28 | 2012-10-26 | Piridopirazinas anticancerigenas via la inhibicion de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr). |
EP12794745.5A EP2776435B1 (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
ARP120104039A AR088567A1 (es) | 2011-10-28 | 2012-10-26 | Derivados de piridopiridazina |
AU2012328170A AU2012328170B2 (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of FGFR kinases |
BR112014010206A BR112014010206B8 (pt) | 2011-10-28 | 2012-10-26 | composto derivado de piridopirazina, composição farmacêutica, e, uso de um composto |
EA201490891A EA027563B1 (ru) | 2011-10-28 | 2012-10-26 | Пиридопиразины, обладающие противораковой активностью через ингибирование fgfr киназ |
AP2014007540A AP4060A (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
ES12794745.5T ES2688868T3 (es) | 2011-10-28 | 2012-10-26 | Piridopirazinas anticáncer a través de la inhibición de FGFR quinasas |
KR1020147010849A KR102066496B1 (ko) | 2011-10-28 | 2012-10-26 | Fgfr 키나제의 억제를 통한 항암 피리도피라진 |
IN948MUN2014 IN2014MN00948A (tr) | 2011-10-28 | 2012-10-26 | |
LTEP12794745.5T LT2776435T (lt) | 2011-10-28 | 2012-10-26 | Piridopirazinų priešvėžinis poveikis per fgfr kinazių slopinimą |
SG11201401055XA SG11201401055XA (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
PCT/GB2012/052672 WO2013061080A1 (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
US14/354,832 US9309242B2 (en) | 2011-10-28 | 2012-10-26 | Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors |
SI201231385T SI2776435T1 (sl) | 2011-10-28 | 2012-10-26 | Antikancerogeni piridopirazini preko inhibicije FGFR kinaz |
CA2853390A CA2853390C (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
JP2014537730A JP6169583B2 (ja) | 2011-10-28 | 2012-10-26 | Fgfrキナーゼの阻害を介した抗癌ピリドピラジン |
NZ622702A NZ622702B2 (en) | 2011-10-28 | 2012-10-26 | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
UY0001034418A UY34418A (es) | 2011-10-28 | 2012-10-26 | Compuestos derivados de la piridopiracina, su preparación, composiciones que los contienen y su uso en terapia |
IL232083A IL232083B (en) | 2011-10-28 | 2014-04-10 | Anticancer pyridopyrazines by inhibiting fgfr kinases |
CO14086785A CO6940422A2 (es) | 2011-10-28 | 2014-04-23 | Piridopirazinas anticancerigenas via la inhibición de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr) |
CR20140190A CR20140190A (es) | 2011-10-28 | 2014-04-25 | Piridopirazinas anticancerigenas via la inhibición de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr) |
CL2014001065A CL2014001065A1 (es) | 2011-10-28 | 2014-04-25 | Compuestos derivados de piridopirazinas; composicion farmaceutica que los comprende; y su uso para la prevencion o el tratamiento de un estado patologico o afeccion mediada por una fgfr cinasa tal como cancer. |
NI201400032A NI201400032A (es) | 2011-10-28 | 2014-04-25 | Piridopirazinas anticancerígenas via la |
ECSP14013325 ECSP14013325A (es) | 2011-10-28 | 2014-04-28 | Piridopirazinas anticancerigenas via la inhibicion de cinasas del receptor del factor de crecimiento de fibroblasto (fgfr) |
US15/019,563 US10045982B2 (en) | 2011-10-28 | 2016-02-09 | Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors |
HRP20181533TT HRP20181533T1 (hr) | 2011-10-28 | 2018-09-26 | Antikancerogeni piridopirazini putem inhibitora fgfr kinaze |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1118656.6A GB201118656D0 (en) | 2011-10-28 | 2011-10-28 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
GB201118656D0 true GB201118656D0 (en) | 2011-12-07 |
Family
ID=45373584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB1118656.6A Ceased GB201118656D0 (en) | 2011-10-28 | 2011-10-28 | New compounds |
Country Status (32)
Country | Link |
---|---|
US (2) | US9309242B2 (tr) |
EP (1) | EP2776435B1 (tr) |
JP (1) | JP6169583B2 (tr) |
KR (1) | KR102066496B1 (tr) |
CN (1) | CN104011051B (tr) |
AP (1) | AP4060A (tr) |
AR (1) | AR088567A1 (tr) |
AU (1) | AU2012328170B2 (tr) |
BR (1) | BR112014010206B8 (tr) |
CA (1) | CA2853390C (tr) |
CL (1) | CL2014001065A1 (tr) |
CO (1) | CO6940422A2 (tr) |
CR (1) | CR20140190A (tr) |
DK (1) | DK2776435T3 (tr) |
EA (1) | EA027563B1 (tr) |
EC (1) | ECSP14013325A (tr) |
ES (1) | ES2688868T3 (tr) |
GB (1) | GB201118656D0 (tr) |
HR (1) | HRP20181533T1 (tr) |
IL (1) | IL232083B (tr) |
IN (1) | IN2014MN00948A (tr) |
JO (1) | JO3419B1 (tr) |
LT (1) | LT2776435T (tr) |
MX (1) | MX353654B (tr) |
MY (1) | MY185666A (tr) |
NI (1) | NI201400032A (tr) |
SG (1) | SG11201401055XA (tr) |
SI (1) | SI2776435T1 (tr) |
TW (1) | TWI602814B (tr) |
UA (1) | UA111386C2 (tr) |
UY (1) | UY34418A (tr) |
WO (1) | WO2013061080A1 (tr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) * | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
EA028819B1 (ru) | 2013-10-25 | 2018-01-31 | Новартис Аг | Производные бициклического пиридила с конденсированными кольцами в качестве ингибиторов fgfr4 |
AR098145A1 (es) * | 2013-10-25 | 2016-05-04 | Novartis Ag | Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4 |
CA2943687C (en) * | 2014-03-26 | 2024-02-13 | Astex Therapeutics Ltd | Combinations of an fgfr inhibitor and an igf1r inhibitor |
WO2015144804A1 (en) | 2014-03-26 | 2015-10-01 | Astex Therapeutics Ltd | Combinations |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
CN106660997B (zh) | 2014-08-18 | 2019-05-21 | 卫材R&D管理有限公司 | 单环吡啶衍生物的盐及其晶体 |
EP3200786B1 (en) * | 2014-10-03 | 2019-08-28 | Novartis AG | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
TWI695837B (zh) | 2014-12-04 | 2020-06-11 | 比利時商健生藥品公司 | 作為激酶調節劑之三唑並嗒 |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US9802917B2 (en) * | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
JP6898919B2 (ja) | 2015-09-23 | 2021-07-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 新規化合物 |
CN108137546B (zh) | 2015-09-23 | 2021-07-27 | 詹森药业有限公司 | 双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途 |
US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
KR20170114254A (ko) * | 2016-03-24 | 2017-10-13 | 재단법인 대구경북첨단의료산업진흥재단 | 신규한 피리딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 fgfr 관련 질환의 예방 또는 치료용 약학적 조성물 |
US11608332B2 (en) | 2016-08-12 | 2023-03-21 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | FGFR4 inhibitor and preparation method and use thereof |
CN108101857B (zh) * | 2016-11-24 | 2021-09-03 | 韶远科技(上海)有限公司 | 制取2-氨基-3-溴-6-氯吡嗪的可放大工艺 |
CN108264510A (zh) * | 2017-01-02 | 2018-07-10 | 上海喆邺生物科技有限公司 | 一种选择性抑制激酶化合物及其用途 |
MX2020008610A (es) | 2018-03-28 | 2020-09-21 | Eisai R&D Man Co Ltd | Agente terapeutico para carcinoma hepatocelular. |
US20230115945A1 (en) | 2019-12-30 | 2023-04-13 | Tyra Biosciences, Inc. | Aminopyrimidine compounds |
WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
AU2021207450A1 (en) * | 2020-01-17 | 2022-08-18 | Beta Pharma, Inc. | Pyridazine and 1,2,4-triazine derivatives as FGFR kinase inhibitors |
KR20230152654A (ko) | 2020-12-30 | 2023-11-03 | 타이라 바이오사이언시스, 인크. | 키나아제 억제제로서의 인다졸 화합물 |
KR20230154436A (ko) | 2021-02-26 | 2023-11-08 | 타이라 바이오사이언시스, 인크. | 아미노피리미딘 화합물 및 그의 사용 방법 |
WO2024006883A1 (en) | 2022-06-29 | 2024-01-04 | Tyra Biosciences, Inc. | Polymorphic compounds and uses thereof |
WO2024006897A1 (en) | 2022-06-29 | 2024-01-04 | Tyra Biosciences, Inc. | Indazole compounds |
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