GB201018996D0 - Novel ROCK inhibitors - Google Patents

Novel ROCK inhibitors

Info

Publication number
GB201018996D0
GB201018996D0 GB201018996A GB201018996A GB201018996D0 GB 201018996 D0 GB201018996 D0 GB 201018996D0 GB 201018996 A GB201018996 A GB 201018996A GB 201018996 A GB201018996 A GB 201018996A GB 201018996 D0 GB201018996 D0 GB 201018996D0
Authority
GB
United Kingdom
Prior art keywords
rock inhibitors
novel rock
novel
inhibitors
rock
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201018996A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amakem NV
Original Assignee
Amakem NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amakem NV filed Critical Amakem NV
Priority to GB201018996A priority Critical patent/GB201018996D0/en
Publication of GB201018996D0 publication Critical patent/GB201018996D0/en
Priority to DK11712789.4T priority patent/DK2542528T3/da
Priority to BR112012021889-1A priority patent/BR112012021889B1/pt
Priority to PCT/EP2011/053343 priority patent/WO2011107608A1/en
Priority to PT117127894T priority patent/PT2542528E/pt
Priority to US13/582,195 priority patent/US8815873B2/en
Priority to CN2013102026660A priority patent/CN103316000A/zh
Priority to EP11712789.4A priority patent/EP2542528B1/en
Priority to KR1020127025686A priority patent/KR101794009B1/ko
Priority to EA201201201A priority patent/EA031616B1/ru
Priority to NZ602191A priority patent/NZ602191A/en
Priority to SG2012059739A priority patent/SG183285A1/en
Priority to PL11712789T priority patent/PL2542528T3/pl
Priority to ES11712789T priority patent/ES2426410T3/es
Priority to EP13165882.5A priority patent/EP2626348A1/en
Priority to JP2012555446A priority patent/JP5710650B2/ja
Priority to AU2011222900A priority patent/AU2011222900B2/en
Priority to CA2791338A priority patent/CA2791338C/en
Priority to MX2012010174A priority patent/MX2012010174A/es
Priority to CN201180011949.6A priority patent/CN102884049B/zh
Priority to IL221676A priority patent/IL221676A/en
Priority to ZA2012/06450A priority patent/ZA201206450B/en
Priority to US13/897,524 priority patent/US8912209B2/en
Ceased legal-status Critical Current

Links

GB201018996A 2010-03-02 2010-11-10 Novel ROCK inhibitors Ceased GB201018996D0 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB201018996A GB201018996D0 (en) 2010-11-10 2010-11-10 Novel ROCK inhibitors
CN201180011949.6A CN102884049B (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺
NZ602191A NZ602191A (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
PL11712789T PL2542528T3 (pl) 2010-03-02 2011-03-04 Heterocykliczne amidy jako inhibitory ROCK
PCT/EP2011/053343 WO2011107608A1 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
PT117127894T PT2542528E (pt) 2010-03-02 2011-03-04 Aminas heterociclicas como inibidores rock
US13/582,195 US8815873B2 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
CN2013102026660A CN103316000A (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺
EP11712789.4A EP2542528B1 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
KR1020127025686A KR101794009B1 (ko) 2010-03-02 2011-03-04 Ｒｏｃｋ 저해제로서 헤테로고리 아미드
EA201201201A EA031616B1 (ru) 2010-03-02 2011-03-04 Новые ингибиторы rock
DK11712789.4T DK2542528T3 (da) 2010-03-02 2011-03-04 Heterocykliske amider som rock-inhibitorer
SG2012059739A SG183285A1 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
BR112012021889-1A BR112012021889B1 (pt) 2010-03-02 2011-03-04 Compostos de amidas heterocíclicas e composição que as compreende para a prevenção ou o tratamento de doenças oculares
ES11712789T ES2426410T3 (es) 2010-03-02 2011-03-04 Amidas heterocíclicas como inhibidores de la ROCK
EP13165882.5A EP2626348A1 (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
JP2012555446A JP5710650B2 (ja) 2010-11-10 2011-03-04 Ｒｏｃｋ阻害剤としての複素環アミド
AU2011222900A AU2011222900B2 (en) 2010-03-02 2011-03-04 Heterocyclic amides as ROCK inhibitors
CA2791338A CA2791338C (en) 2010-03-02 2011-03-04 Heterocyclic amides as rock inhibitors
MX2012010174A MX2012010174A (es) 2010-03-02 2011-03-04 Inhibidores novedosos de rock.
ZA2012/06450A ZA201206450B (en) 2010-03-02 2012-08-28 Heterocyclic amides as rock inhibitors
IL221676A IL221676A (en) 2010-03-02 2012-08-28 Affluent heterocycles as rock inhibitors
US13/897,524 US8912209B2 (en) 2010-03-02 2013-05-20 Rock inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201018996A GB201018996D0 (en) 2010-11-10 2010-11-10 Novel ROCK inhibitors

Publications (1)

Publication Number Publication Date
GB201018996D0 true GB201018996D0 (en) 2010-12-22

Family

ID=43414658

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201018996A Ceased GB201018996D0 (en) 2010-03-02 2010-11-10 Novel ROCK inhibitors

Country Status (3)

Country Link
JP (1) JP5710650B2 (zh)
CN (2) CN103316000A (zh)
GB (1) GB201018996D0 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014002395A (es) * 2011-08-31 2014-06-05 Amakem Nv Inhibidores de rock suaves, novedosos.
CN108047194A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途
CN108191820A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含异丙胺和噻吩酰胺类结构的化合物
CN107935986A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途
CN108047195A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 一种含丙二醇腈基噻吩酰胺类化合物及其用途
CN107915717A (zh) * 2017-12-31 2018-04-17 佛山市赛维斯医药科技有限公司 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途
CN108101885A (zh) * 2017-12-31 2018-06-01 佛山市赛维斯医药科技有限公司 含异丙胺和硝基噻吩酰胺类结构化合物、其制备方法及用途
CN108129452A (zh) * 2017-12-31 2018-06-08 佛山市赛维斯医药科技有限公司 一种含异丙基萘和丙二醇硝基噻吩酰胺类化合物及其用途
CN107935987A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途
CN108191821A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含甲基萘和腈基噻吩酰胺类结构的rock抑制剂及用途
CN108047193A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途
CN114956977B (zh) * 2022-06-09 2024-03-26 朗捷睿(苏州)生物科技有限公司 一种联苯类化合物、药物组合物及其制备方法和应用
WO2024149366A1 (zh) * 2023-01-13 2024-07-18 武汉朗来科技发展有限公司 一种rock抑制剂中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101248046A (zh) * 2005-07-11 2008-08-20 德福根有限公司 作为激酶抑制剂的酰胺衍生物
BRPI0615522A2 (pt) * 2005-07-11 2012-04-10 Devgen Nv derivados da amida como inibidores da quinase
WO2007042321A2 (en) * 2005-10-13 2007-04-19 Devgen N.V. Kinase inhibitors
RU2008148962A (ru) * 2006-05-12 2010-06-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Избирательно действующие ингибиторы rоск протеинкиназы и их применение
CN101903349B (zh) * 2007-08-27 2014-01-08 Abbvie德国有限责任两合公司 4-(4-吡啶基)-苯甲酰胺及其作为rock活性调节剂的应用
MX2011002825A (es) * 2008-09-18 2011-04-05 Astellas Pharma Inc Compuestos heterociclicos de carboxamida.

Also Published As

Publication number Publication date
CN103316000A (zh) 2013-09-25
JP5710650B2 (ja) 2015-04-30
CN102884049A (zh) 2013-01-16
CN102884049B (zh) 2016-08-24
JP2013527136A (ja) 2013-06-27

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)