GB1595220A - Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane - Google Patents
Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane Download PDFInfo
- Publication number
- GB1595220A GB1595220A GB53825/77A GB5382577A GB1595220A GB 1595220 A GB1595220 A GB 1595220A GB 53825/77 A GB53825/77 A GB 53825/77A GB 5382577 A GB5382577 A GB 5382577A GB 1595220 A GB1595220 A GB 1595220A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition according
- weight
- bis
- bicarbonate
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 title claims abstract description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 32
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 19
- -1 alkaline earth metal carbonate Chemical class 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 5
- 239000012530 fluid Substances 0.000 claims abstract description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 9
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims description 7
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- 235000011181 potassium carbonates Nutrition 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 235000015424 sodium Nutrition 0.000 claims description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000012298 atmosphere Substances 0.000 claims description 2
- 150000004777 chromones Chemical class 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 1
- 150000008041 alkali metal carbonates Chemical class 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 5
- 239000002253 acid Substances 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000011231 Crohn disease Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000008105 immune reaction Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 208000004300 Atrophic Gastritis Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000015943 Coeliac disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 244000089409 Erythrina poeppigiana Species 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 206010016946 Food allergy Diseases 0.000 description 1
- 208000036495 Gastritis atrophic Diseases 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 235000009776 Rathbunia alamosensis Nutrition 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000016644 chronic atrophic gastritis Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 201000005298 gastrointestinal allergy Diseases 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- PFMBRNMAXCVTIV-UHFFFAOYSA-K trisodium hydrogen carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.OC([O-])=O.OC([O-])=O PFMBRNMAXCVTIV-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB53825/77A GB1595220A (en) | 1977-12-23 | 1977-12-23 | Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane |
| AU42654/78A AU523616B2 (en) | 1977-12-23 | 1978-12-18 | 1,3-bis (2-carboxychromon-5-yloxy)-2-hydroxypropane formulation |
| IL56239A IL56239A (en) | 1977-12-23 | 1978-12-18 | Pharmaceutical compositions comprising certain 1,3-bis-2-carboxy chromonyloxy-2-hydroxypropane salts |
| DK568278A DK568278A (da) | 1977-12-23 | 1978-12-18 | Fremgangsmaade til fremstilling af et pharmaceutisk praeparat |
| CH1290478A CH641349A5 (en) | 1977-12-23 | 1978-12-19 | Disintegrable tablet containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane or one of its pharmaceutically acceptable salts |
| FI783897A FI783897A7 (fi) | 1977-12-23 | 1978-12-19 | Formulering |
| SE7813062A SE7813062L (sv) | 1977-12-23 | 1978-12-19 | Farmaceutisk komposition |
| NZ189255A NZ189255A (en) | 1977-12-23 | 1978-12-20 | Pharmaceutical compositions containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxy propane |
| IT7831068A IT7831068A0 (it) | 1977-12-23 | 1978-12-20 | Formulazione. |
| ZA00787155A ZA787155B (en) | 1977-12-23 | 1978-12-20 | Tablet formulations of bis-chromones |
| DE19782855001 DE2855001A1 (de) | 1977-12-23 | 1978-12-20 | Pharmazeutisches praeparat und seine herstellung |
| NL7812344A NL7812344A (nl) | 1977-12-23 | 1978-12-20 | Farmaceutisch preparaat. |
| BE192444A BE872918A (fr) | 1977-12-23 | 1978-12-20 | Composition pharmaceutique |
| CA318,406A CA1108992A (en) | 1977-12-23 | 1978-12-21 | Pharmaceutical composition containing 1,3-bis(2- carboxychromon-5-yloxy)2-hydroxypropane |
| JP15697478A JPS5489016A (en) | 1977-12-23 | 1978-12-21 | Pharmaceutical composition for stomach and intestine |
| IE2540/78A IE47539B1 (en) | 1977-12-23 | 1978-12-21 | Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane |
| FR7836221A FR2412310A1 (fr) | 1977-12-23 | 1978-12-22 | Comprime pharmaceutique comprenant du 1,3-bis(2-carboxychromone-5-yloxy)-2-hydroxypropane, utile pour le traitement d'affections gastro-intestinales |
| LU80721A LU80721A1 (fr) | 1977-12-23 | 1978-12-22 | Composition pharmaceutique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB53825/77A GB1595220A (en) | 1977-12-23 | 1977-12-23 | Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1595220A true GB1595220A (en) | 1981-08-12 |
Family
ID=10469110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB53825/77A Expired GB1595220A (en) | 1977-12-23 | 1977-12-23 | Tablets containing 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane |
Country Status (18)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000027392A1 (en) * | 1998-11-11 | 2000-05-18 | Hewlett Healthcare Limited | Chromone enteric release formulation |
| WO2002045684A3 (en) * | 2000-12-06 | 2003-03-13 | Pharmacia Corp | Rapidly dispersing pharmaceutical composition comprising effervescent agents |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07116017B2 (ja) * | 1986-05-17 | 1995-12-13 | アース製薬株式会社 | 入浴剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2132521A1 (en) * | 1971-04-06 | 1972-11-24 | Sofrader Sa | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
| GB1423985A (en) * | 1972-02-15 | 1976-02-04 | Fisons Ltd | Pharmaceutical compositions containing bischromonyloxy compounds |
| GB1517153A (en) * | 1974-11-30 | 1978-07-12 | Fisons Ltd | Naphthopyran-and benzodipyran-2-carboxylic acids and derivatives thereof |
| GB1570993A (en) * | 1976-05-21 | 1980-07-09 | Fisons Ltd | Pharmaceutical tablet formulation |
| GB1557082A (en) * | 1977-01-25 | 1979-12-05 | Fisons Ltd | Pharmaceutical mixture containing an antiinflammatory |
-
1977
- 1977-12-23 GB GB53825/77A patent/GB1595220A/en not_active Expired
-
1978
- 1978-12-18 AU AU42654/78A patent/AU523616B2/en not_active Expired
- 1978-12-18 IL IL56239A patent/IL56239A/xx unknown
- 1978-12-18 DK DK568278A patent/DK568278A/da not_active Application Discontinuation
- 1978-12-19 CH CH1290478A patent/CH641349A5/fr not_active IP Right Cessation
- 1978-12-19 FI FI783897A patent/FI783897A7/fi unknown
- 1978-12-19 SE SE7813062A patent/SE7813062L/xx unknown
- 1978-12-20 NL NL7812344A patent/NL7812344A/xx not_active Application Discontinuation
- 1978-12-20 ZA ZA00787155A patent/ZA787155B/xx unknown
- 1978-12-20 NZ NZ189255A patent/NZ189255A/en unknown
- 1978-12-20 BE BE192444A patent/BE872918A/xx not_active IP Right Cessation
- 1978-12-20 DE DE19782855001 patent/DE2855001A1/de not_active Withdrawn
- 1978-12-20 IT IT7831068A patent/IT7831068A0/it unknown
- 1978-12-21 JP JP15697478A patent/JPS5489016A/ja active Pending
- 1978-12-21 IE IE2540/78A patent/IE47539B1/en unknown
- 1978-12-21 CA CA318,406A patent/CA1108992A/en not_active Expired
- 1978-12-22 FR FR7836221A patent/FR2412310A1/fr active Granted
- 1978-12-22 LU LU80721A patent/LU80721A1/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000027392A1 (en) * | 1998-11-11 | 2000-05-18 | Hewlett Healthcare Limited | Chromone enteric release formulation |
| US7258872B1 (en) | 1998-11-11 | 2007-08-21 | Thornton & Ross Limited | Chromone enteric release formulation |
| WO2002045684A3 (en) * | 2000-12-06 | 2003-03-13 | Pharmacia Corp | Rapidly dispersing pharmaceutical composition comprising effervescent agents |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7813062L (sv) | 1979-06-24 |
| FI783897A7 (fi) | 1979-06-24 |
| IT7831068A0 (it) | 1978-12-20 |
| BE872918A (fr) | 1979-06-20 |
| IE47539B1 (en) | 1984-04-18 |
| AU4265478A (en) | 1979-06-28 |
| ZA787155B (en) | 1979-12-27 |
| NL7812344A (nl) | 1979-06-26 |
| CH641349A5 (en) | 1984-02-29 |
| DE2855001A1 (de) | 1979-07-05 |
| DK568278A (da) | 1979-06-24 |
| NZ189255A (en) | 1984-05-31 |
| JPS5489016A (en) | 1979-07-14 |
| FR2412310B1 (enrdf_load_stackoverflow) | 1982-12-31 |
| IE782540L (en) | 1979-06-23 |
| IL56239A0 (en) | 1979-03-12 |
| AU523616B2 (en) | 1982-08-05 |
| IL56239A (en) | 1983-02-23 |
| FR2412310A1 (fr) | 1979-07-20 |
| LU80721A1 (fr) | 1979-09-07 |
| CA1108992A (en) | 1981-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |