GB1595165A - Process for the manufacture of cholesterol derivatives via 1,2-epoxy intermediates - Google Patents

Process for the manufacture of cholesterol derivatives via 1,2-epoxy intermediates Download PDF

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Publication number
GB1595165A
GB1595165A GB3000/78A GB300078A GB1595165A GB 1595165 A GB1595165 A GB 1595165A GB 3000/78 A GB3000/78 A GB 3000/78A GB 300078 A GB300078 A GB 300078A GB 1595165 A GB1595165 A GB 1595165A
Authority
GB
United Kingdom
Prior art keywords
process according
epoxyalcohol
hydroxyl group
formula
inclusive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3000/78A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1595165A publication Critical patent/GB1595165A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
GB3000/78A 1977-01-26 1978-01-25 Process for the manufacture of cholesterol derivatives via 1,2-epoxy intermediates Expired GB1595165A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/762,604 US4098801A (en) 1977-01-26 1977-01-26 Synthesis of 1α-hydroxylated derivatives of cholesterol

Publications (1)

Publication Number Publication Date
GB1595165A true GB1595165A (en) 1981-08-12

Family

ID=25065548

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3000/78A Expired GB1595165A (en) 1977-01-26 1978-01-25 Process for the manufacture of cholesterol derivatives via 1,2-epoxy intermediates

Country Status (9)

Country Link
US (1) US4098801A (enExample)
JP (1) JPS5392755A (enExample)
AT (1) AT357278B (enExample)
BE (1) BE863284A (enExample)
CH (1) CH629505A5 (enExample)
DE (1) DE2803236C2 (enExample)
FR (1) FR2378798A1 (enExample)
GB (1) GB1595165A (enExample)
NL (1) NL7800086A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6039278B2 (ja) * 1977-05-23 1985-09-05 中外製薬株式会社 ステロイド誘導体
US4229358A (en) * 1978-07-26 1980-10-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901928A (en) * 1973-01-10 1975-08-26 Robert Henry Hesse 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US3887545A (en) * 1973-11-12 1975-06-03 Hoffmann La Roche Synthesis of 1{60 -hydroxylated cholesterol derivatives

Also Published As

Publication number Publication date
DE2803236A1 (de) 1978-07-27
JPS5392755A (en) 1978-08-15
ATA55178A (de) 1979-11-15
AT357278B (de) 1980-06-25
CH629505A5 (de) 1982-04-30
FR2378798A1 (fr) 1978-08-25
NL7800086A (nl) 1978-07-28
JPS5517038B2 (enExample) 1980-05-08
US4098801A (en) 1978-07-04
BE863284A (fr) 1978-07-25
FR2378798B1 (enExample) 1982-07-09
DE2803236C2 (de) 1984-06-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee