GB1579532A - Cephalosporins - Google Patents

Cephalosporins Download PDF

Info

Publication number
GB1579532A
GB1579532A GB21032/76A GB2103276A GB1579532A GB 1579532 A GB1579532 A GB 1579532A GB 21032/76 A GB21032/76 A GB 21032/76A GB 2103276 A GB2103276 A GB 2103276A GB 1579532 A GB1579532 A GB 1579532A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
ylthiomethyl
pyrazin
cephem
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21032/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB21032/76A priority Critical patent/GB1579532A/en
Priority to AU25071/77A priority patent/AU509448B2/en
Priority to NL7705262A priority patent/NL7705262A/xx
Priority to ZA00772859A priority patent/ZA772859B/xx
Priority to NZ184110A priority patent/NZ184110A/xx
Priority to CS773205A priority patent/CS199676B2/cs
Priority to US05/797,606 priority patent/US4148996A/en
Priority to AT348977A priority patent/AT355719B/de
Priority to YU01230/77A priority patent/YU123077A/xx
Priority to FR7715045A priority patent/FR2424922A1/fr
Priority to DK216877A priority patent/DK216877A/da
Priority to NO771744A priority patent/NO771744L/no
Priority to SE7705934A priority patent/SE433851B/xx
Priority to DE2722666A priority patent/DE2722666C2/de
Priority to IL52123A priority patent/IL52123A/xx
Priority to CH625577A priority patent/CH639095A5/de
Priority to CA278,851A priority patent/CA1102790A/en
Priority to HU77SO1190A priority patent/HU174072B/hu
Priority to JP5862277A priority patent/JPS52142093A/ja
Priority to SU772483403A priority patent/SU799669A3/ru
Priority to GR53525A priority patent/GR73013B/el
Priority to BE177745A priority patent/BE854845A/xx
Publication of GB1579532A publication Critical patent/GB1579532A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB21032/76A 1976-05-21 1976-05-21 Cephalosporins Expired GB1579532A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB21032/76A GB1579532A (en) 1976-05-21 1976-05-21 Cephalosporins
AU25071/77A AU509448B2 (en) 1976-05-21 1977-05-11 Cephalosporins
NL7705262A NL7705262A (nl) 1976-05-21 1977-05-12 Werkwijze voor het bereiden van gesubstitueer- de cefalosporinen.
ZA00772859A ZA772859B (en) 1976-05-21 1977-05-13 3,7-disubstituted cephalosporins and preparation thereof
NZ184110A NZ184110A (en) 1976-05-21 1977-05-16 Cephalosporins with an optionally substituted pyrazinyl-thio-methyl substituted in the 3-position
CS773205A CS199676B2 (en) 1976-05-21 1977-05-16 Method of producing derivatives of 7-acylamino-pyrazinylthiomethyl-3-cephem-4-carboxylic acid
US05/797,606 US4148996A (en) 1976-05-21 1977-05-16 3,7-Disubstituted cephalosporins
AT348977A AT355719B (de) 1976-05-21 1977-05-16 Verfahren zur herstellung von neuen 3,7- disubstituierten cephalosporinen
YU01230/77A YU123077A (en) 1976-05-21 1977-05-17 Process for obtaining 3,7-disubstituted cephalosporins
FR7715045A FR2424922A1 (fr) 1976-05-21 1977-05-17 Cephalosporines 3,7-disubstituees a activite antibacterienne et procede pour les preparer
DK216877A DK216877A (da) 1976-05-21 1977-05-18 Fremgangsmade til fremstilling af 3,7-disubstituerede cefalosporiner
NO771744A NO771744L (no) 1976-05-21 1977-05-18 Fremgangsm}te for fremstilling av 3,7-disubstituerte cefalosporiner
SE7705934A SE433851B (sv) 1976-05-21 1977-05-18 Forfarande for framstellning av cefalosporinderivat
DE2722666A DE2722666C2 (de) 1976-05-21 1977-05-18 7-Acylamino-3-pyrazinylthiomethyl- 3-cephem-4-carbonsäure-Verbindungen und ihre Verwendung/Bekämpfung bakterieller Infektionen
IL52123A IL52123A (en) 1976-05-21 1977-05-19 7-acylamino-3-pyrazinylthiomethyl-3-cephem-4-carboxylic acids and preparation thereof
CH625577A CH639095A5 (de) 1976-05-21 1977-05-20 Verfahren zur herstellung von 3,7-disubstituierten cephalosporinen.
CA278,851A CA1102790A (en) 1976-05-21 1977-05-20 3,7-disubstituted cephalosporins and preparation thereof
HU77SO1190A HU174072B (hu) 1976-05-21 1977-05-20 Sposob poluchenija novykh proizvodnykh cef-em-4-karbonovojj kisloty, dvoe-zamehhennykh b pozicijakh 3 i 7
JP5862277A JPS52142093A (en) 1976-05-21 1977-05-20 77acylaminoo33pyrazinylthiomethyll 33cephemm44carboxylate process for preparing same and antibiotic pharmaceutical composition containing same
SU772483403A SU799669A3 (ru) 1976-05-21 1977-05-20 Способ получени цефалоспоринов
GR53525A GR73013B (de) 1976-05-21 1977-05-20
BE177745A BE854845A (fr) 1976-05-21 1977-05-20 Cephalosporines 3,7-disubstituees a activite antibacterienne et procede pour les preparer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB21032/76A GB1579532A (en) 1976-05-21 1976-05-21 Cephalosporins

Publications (1)

Publication Number Publication Date
GB1579532A true GB1579532A (en) 1980-11-19

Family

ID=10156029

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21032/76A Expired GB1579532A (en) 1976-05-21 1976-05-21 Cephalosporins

Country Status (22)

Country Link
US (1) US4148996A (de)
JP (1) JPS52142093A (de)
AT (1) AT355719B (de)
AU (1) AU509448B2 (de)
BE (1) BE854845A (de)
CA (1) CA1102790A (de)
CH (1) CH639095A5 (de)
CS (1) CS199676B2 (de)
DE (1) DE2722666C2 (de)
DK (1) DK216877A (de)
FR (1) FR2424922A1 (de)
GB (1) GB1579532A (de)
GR (1) GR73013B (de)
HU (1) HU174072B (de)
IL (1) IL52123A (de)
NL (1) NL7705262A (de)
NO (1) NO771744L (de)
NZ (1) NZ184110A (de)
SE (1) SE433851B (de)
SU (1) SU799669A3 (de)
YU (1) YU123077A (de)
ZA (1) ZA772859B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10533018B2 (en) 2015-06-29 2020-01-14 Duke University Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL38099A (en) * 1970-12-17 1976-01-30 Smith Kline French Lab 3-heterocyclyl thiomethylcephalosporins
US4007173A (en) * 1973-05-07 1977-02-08 Smithkline Corporation α-amino-α-(ureidophenyl)acetamidocephalosporins
DE2359544A1 (de) * 1973-11-29 1975-10-30 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US3960849A (en) * 1974-03-13 1976-06-01 E. R. Squibb & Sons, Inc. Amino-1,2,4-oxadiazolyl-3-acetyl cephalosporins
DE2512284A1 (de) * 1974-03-28 1975-10-09 Fujisawa Pharmaceutical Co Cephalosporansaeurederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
FR2424922A1 (fr) 1979-11-30
DE2722666C2 (de) 1982-04-15
SE433851B (sv) 1984-06-18
HU174072B (hu) 1979-10-28
BE854845A (fr) 1977-11-21
GR73013B (de) 1984-01-25
CA1102790A (en) 1981-06-09
DE2722666A1 (de) 1977-12-01
AU509448B2 (en) 1980-05-15
IL52123A0 (en) 1977-07-31
SE7705934L (sv) 1977-11-22
NL7705262A (nl) 1977-11-23
NO771744L (no) 1977-11-22
ATA348977A (de) 1979-08-15
AT355719B (de) 1980-03-25
IL52123A (en) 1980-11-30
NZ184110A (en) 1979-08-31
FR2424922B1 (de) 1983-07-08
ZA772859B (en) 1978-04-26
AU2507177A (en) 1978-11-16
US4148996A (en) 1979-04-10
CH639095A5 (de) 1983-10-31
SU799669A3 (ru) 1981-01-23
CS199676B2 (en) 1980-07-31
JPS52142093A (en) 1977-11-26
DK216877A (da) 1977-11-22
YU123077A (en) 1982-10-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee