GB1578739A - Amine salts of clavulanic acid methods for their preparation and compositions containing them - Google Patents

Amine salts of clavulanic acid methods for their preparation and compositions containing them Download PDF

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Publication number
GB1578739A
GB1578739A GB30752/76A GB3075276A GB1578739A GB 1578739 A GB1578739 A GB 1578739A GB 30752/76 A GB30752/76 A GB 30752/76A GB 3075276 A GB3075276 A GB 3075276A GB 1578739 A GB1578739 A GB 1578739A
Authority
GB
United Kingdom
Prior art keywords
salt
formula
clavulanic acid
pharmaceutical composition
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30752/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB30752/76A priority Critical patent/GB1578739A/en
Priority to JP8783777A priority patent/JPS5315408A/ja
Priority to FR7722214A priority patent/FR2359144A1/fr
Priority to DE19772733230 priority patent/DE2733230A1/de
Publication of GB1578739A publication Critical patent/GB1578739A/en
Priority to US06/791,907 priority patent/US4650795A/en
Priority to HK410/86A priority patent/HK41086A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
GB30752/76A 1976-07-23 1976-07-23 Amine salts of clavulanic acid methods for their preparation and compositions containing them Expired GB1578739A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB30752/76A GB1578739A (en) 1976-07-23 1976-07-23 Amine salts of clavulanic acid methods for their preparation and compositions containing them
JP8783777A JPS5315408A (en) 1976-07-23 1977-07-20 Antibacterial agent
FR7722214A FR2359144A1 (fr) 1976-07-23 1977-07-20 Sels de l'acide clavulanique utilisable comme medicaments
DE19772733230 DE2733230A1 (de) 1976-07-23 1977-07-22 Clavulansaeure-salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
US06/791,907 US4650795A (en) 1976-07-23 1985-10-28 Amine salts of clavulanic acid as antibacterial agents
HK410/86A HK41086A (en) 1976-07-23 1986-05-29 Amine saits of clavulanic acid,methods for their preparation and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30752/76A GB1578739A (en) 1976-07-23 1976-07-23 Amine salts of clavulanic acid methods for their preparation and compositions containing them

Publications (1)

Publication Number Publication Date
GB1578739A true GB1578739A (en) 1980-11-05

Family

ID=10312587

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30752/76A Expired GB1578739A (en) 1976-07-23 1976-07-23 Amine salts of clavulanic acid methods for their preparation and compositions containing them

Country Status (6)

Country Link
US (1) US4650795A (US07709020-20100504-C00041.png)
JP (1) JPS5315408A (US07709020-20100504-C00041.png)
DE (1) DE2733230A1 (US07709020-20100504-C00041.png)
FR (1) FR2359144A1 (US07709020-20100504-C00041.png)
GB (1) GB1578739A (US07709020-20100504-C00041.png)
HK (1) HK41086A (US07709020-20100504-C00041.png)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647659A (en) * 1979-08-24 1987-03-03 Beecham Group P.L.C. Clavulanic acid amine salts, their preparation and use
WO1993014770A1 (en) 1992-01-25 1993-08-05 Smithkline Beecham Plc Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivative
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid
ES2058029A1 (es) * 1992-03-10 1994-10-16 Biochemie Gmbh Proceso para la produccion de sales del acido clavulanico.
GB2282810A (en) * 1992-06-11 1995-04-19 Smithkline Beecham Plc Process for the preparation of clavulanic acid
AT475U1 (de) * 1992-06-11 1995-11-27 Smithkline Beecham Plc Verfahren zur herstellung von clavulansaeure
WO1996020199A2 (en) 1994-12-24 1996-07-04 Spurcourt Limited Diclavulanate salt with a diamino ether and process of preparation
AT1447U1 (de) * 1992-06-11 1997-05-26 Smithkline Beecham Plc Neue salze von clavulansäure
AT1446U1 (de) * 1992-10-31 1997-05-26 Smithkline Beecham Plc Verfahren zur herstellung und/oder reinigung von clavulansäure
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
US5859238A (en) * 1992-03-26 1999-01-12 Lek, Tovarna Farmacevtskih Alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof
AP749A (en) * 1995-02-25 1999-07-05 Spurcourt Ltd Clavulanic acid salts.
US5985625A (en) * 1994-03-02 1999-11-16 Lek Pharmaceutical & Chemical Co. Dd Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804
WO2000004028A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
US6127358A (en) * 1995-08-28 2000-10-03 Urquhart-Dykes & Lord Isolation of clavulanic acid from fermentation broth by ultrafiltration

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2861607D1 (en) * 1977-11-26 1982-03-11 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
US4797396A (en) * 1984-07-02 1989-01-10 Merck & Co., Inc. β-Lactam derivatives as anti-inflammatory and antidegenerative agents
SI0647229T1 (en) * 1993-03-26 1997-10-31 Gist Brocades Nv Diamine salts of clavulanic acid
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
CN108546269B (zh) * 2018-05-22 2019-10-11 国药集团威奇达药业有限公司 从结晶母液中回收克拉维酸叔丁胺盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1493197A (en) * 1975-07-04 1977-11-23 Beecham Group Ltd Amides of clavulanic acid

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647659A (en) * 1979-08-24 1987-03-03 Beecham Group P.L.C. Clavulanic acid amine salts, their preparation and use
WO1993014770A1 (en) 1992-01-25 1993-08-05 Smithkline Beecham Plc Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivative
ES2058029A1 (es) * 1992-03-10 1994-10-16 Biochemie Gmbh Proceso para la produccion de sales del acido clavulanico.
USH2158H1 (en) 1992-03-10 2006-06-06 Sandoz Ag Process for the production of clavulanic acid salts
US5859238A (en) * 1992-03-26 1999-01-12 Lek, Tovarna Farmacevtskih Alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof
DE4345311C1 (de) * 1992-06-11 1996-02-01 Smithkline Beecham Plc Verfahren zur Herstellung und/oder Reinigung von Clavulansäure
AP474A (en) * 1992-06-11 1996-03-06 Smithkline Beecham Plc Process for the preparation of clavulanic acid.
AT475U1 (de) * 1992-06-11 1995-11-27 Smithkline Beecham Plc Verfahren zur herstellung von clavulansaeure
EP0672670A1 (en) 1992-06-11 1995-09-20 Smithkline Beecham Plc Process for the preparation of clavulanic acid
AP471A (en) * 1992-06-11 1996-03-06 Smithkline Beecham Plc Process for the preparation of clavulanic acid.
EP0699682A1 (en) 1992-06-11 1996-03-06 Smithkline Beecham P.L.C. Process for the preparation and/or purification of clavulanic acid
AP473A (en) * 1992-06-11 1996-03-06 Smithkline Beecham Plc Process for the preparation of clavulanic acid.
EP0672669A1 (en) * 1992-06-11 1995-09-20 Smithkline Beecham Plc Process for the preparation of clavulanic acid
GB2282810A (en) * 1992-06-11 1995-04-19 Smithkline Beecham Plc Process for the preparation of clavulanic acid
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
AT1447U1 (de) * 1992-06-11 1997-05-26 Smithkline Beecham Plc Neue salze von clavulansäure
WO1993025557A1 (en) * 1992-06-11 1993-12-23 Smithkline Beecham Plc Process for the preparation of clavulanic acid
AU680099B2 (en) * 1992-06-11 1997-07-17 Smithkline Beecham Plc Process for the preparation of clavulanic acid
CN1041934C (zh) * 1992-06-11 1999-02-03 史密丝克莱恩比彻姆有限公司 制备和／或纯化棒酸或其药用盐或其酯的新方法
AT1446U1 (de) * 1992-10-31 1997-05-26 Smithkline Beecham Plc Verfahren zur herstellung und/oder reinigung von clavulansäure
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
US5985625A (en) * 1994-03-02 1999-11-16 Lek Pharmaceutical & Chemical Co. Dd Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804
US6207428B1 (en) 1994-03-02 2001-03-27 Lek Pharmaceutical & Chemical Co. D.D. Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804
US6566106B2 (en) 1994-03-02 2003-05-20 Lek Pharmaceutical & Chemical Co., D.D. Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof
US5786351A (en) * 1994-12-24 1998-07-28 Spurcourt Limited Clavulanic acid salts
MD1738F2 (ro) * 1994-12-24 2001-09-30 Spurcourt Limited Sare de diclavulanat, procedeu de obţinere şi compoziţie farmaceutică pe baza ei
WO1996020199A2 (en) 1994-12-24 1996-07-04 Spurcourt Limited Diclavulanate salt with a diamino ether and process of preparation
AP749A (en) * 1995-02-25 1999-07-05 Spurcourt Ltd Clavulanic acid salts.
MD1744F2 (ro) * 1995-02-25 2001-09-30 Spurcourt Limited Săruri ale acidului clavulanic şi procedeu de obţinere a lor
US6127358A (en) * 1995-08-28 2000-10-03 Urquhart-Dykes & Lord Isolation of clavulanic acid from fermentation broth by ultrafiltration
US6274575B1 (en) 1995-08-28 2001-08-14 Lek Pharmaceutical And Chemical Co. D. D. Isolation of clavulanic acid from fermentation broth by ultrafiltration
WO2000004028A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid

Also Published As

Publication number Publication date
FR2359144A1 (fr) 1978-02-17
US4650795A (en) 1987-03-17
HK41086A (en) 1986-06-06
JPS6224435B2 (US07709020-20100504-C00041.png) 1987-05-28
FR2359144B1 (US07709020-20100504-C00041.png) 1980-09-12
DE2733230C2 (US07709020-20100504-C00041.png) 1993-08-12
DE2733230A1 (de) 1978-01-26
JPS5315408A (en) 1978-02-13

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19970718