GB1561305A - Benzazepine derivatives and pharmeceutical compositions containing them - Google Patents

Benzazepine derivatives and pharmeceutical compositions containing them Download PDF

Info

Publication number
GB1561305A
GB1561305A GB25008/76A GB2500876A GB1561305A GB 1561305 A GB1561305 A GB 1561305A GB 25008/76 A GB25008/76 A GB 25008/76A GB 2500876 A GB2500876 A GB 2500876A GB 1561305 A GB1561305 A GB 1561305A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
tetrahydro
phenyl
compound according
benzazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25008/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/592,708 external-priority patent/US4011319A/en
Priority claimed from US05/602,042 external-priority patent/US4052506A/en
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of GB1561305A publication Critical patent/GB1561305A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
GB25008/76A 1975-07-02 1976-06-17 Benzazepine derivatives and pharmeceutical compositions containing them Expired GB1561305A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/592,708 US4011319A (en) 1975-07-02 1975-07-02 Pharmaceutical compositions and methods involving benzazepine derivatives
US05/602,042 US4052506A (en) 1975-08-05 1975-08-05 Pharmaceutical compositions and method of producing anti-parkinsonism activity

Publications (1)

Publication Number Publication Date
GB1561305A true GB1561305A (en) 1980-02-20

Family

ID=27081519

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25008/76A Expired GB1561305A (en) 1975-07-02 1976-06-17 Benzazepine derivatives and pharmeceutical compositions containing them

Country Status (10)

Country Link
JP (1) JPS527981A (nl)
AU (1) AU507272B2 (nl)
CA (1) CA1079639A (nl)
DE (1) DE2629887A1 (nl)
FR (1) FR2315934A1 (nl)
GB (1) GB1561305A (nl)
IE (1) IE43920B1 (nl)
IL (1) IL49931A (nl)
LU (1) LU75269A1 (nl)
NL (1) NL7607184A (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053936A1 (en) * 2001-12-20 2003-07-03 Shire Pharmaceutical Development Ltd Dopamine d1 receptor agonist pro-drug compounds & derivatives

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4104379A (en) * 1977-01-19 1978-08-01 Smithkline Corporation Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
ZA777444B (en) * 1977-01-19 1978-10-25 Smithkline Corp Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity
US4490392A (en) * 1977-08-11 1984-12-25 Tanabe Seiyaku Co., Ltd. Benzylalcohol derivative and process for preparing
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
ATE5634T1 (de) * 1979-07-10 1984-01-15 Smithkline Beckman Corporation Synergistische blutdrucksenkende zusammensetzungen.
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
US7504391B2 (en) * 2003-05-22 2009-03-17 Schering Corporation Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053936A1 (en) * 2001-12-20 2003-07-03 Shire Pharmaceutical Development Ltd Dopamine d1 receptor agonist pro-drug compounds & derivatives

Also Published As

Publication number Publication date
IL49931A (en) 1981-12-31
NL7607184A (nl) 1977-01-04
IE43920L (en) 1977-01-02
CA1079639A (en) 1980-06-17
IE43920B1 (en) 1981-07-01
FR2315934A1 (fr) 1977-01-28
AU1554076A (en) 1978-01-05
LU75269A1 (nl) 1977-02-18
IL49931A0 (en) 1976-08-31
AU507272B2 (en) 1980-02-07
FR2315934B1 (nl) 1978-11-17
JPS527981A (en) 1977-01-21
DE2629887A1 (de) 1977-01-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee