GB1529782A - Disubstituted derivatives of piperazine a method of preparation of the said derivatives and therapeutic applications thereof - Google Patents

Disubstituted derivatives of piperazine a method of preparation of the said derivatives and therapeutic applications thereof

Info

Publication number
GB1529782A
GB1529782A GB1317377A GB1317377A GB1529782A GB 1529782 A GB1529782 A GB 1529782A GB 1317377 A GB1317377 A GB 1317377A GB 1317377 A GB1317377 A GB 1317377A GB 1529782 A GB1529782 A GB 1529782A
Authority
GB
United Kingdom
Prior art keywords
derivatives
piperazine
preparation
therapeutic applications
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1317377A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAUBA UNIV D ORLEANS LAB
Original Assignee
SAUBA UNIV D ORLEANS LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SAUBA UNIV D ORLEANS LAB filed Critical SAUBA UNIV D ORLEANS LAB
Publication of GB1529782A publication Critical patent/GB1529782A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1317377A 1976-05-06 1977-03-29 Disubstituted derivatives of piperazine a method of preparation of the said derivatives and therapeutic applications thereof Expired GB1529782A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7613592A FR2350100A1 (fr) 1976-05-06 1976-05-06 Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques

Publications (1)

Publication Number Publication Date
GB1529782A true GB1529782A (en) 1978-10-25

Family

ID=9172778

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1317377A Expired GB1529782A (en) 1976-05-06 1977-03-29 Disubstituted derivatives of piperazine a method of preparation of the said derivatives and therapeutic applications thereof

Country Status (4)

Country Link
DE (1) DE2719246C2 (fr)
ES (1) ES456988A1 (fr)
FR (1) FR2350100A1 (fr)
GB (1) GB1529782A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194336A2 (fr) * 1985-03-11 1986-09-17 Taiyo Pharmaceutical Industry Co., Ltd. Formulation orale de mobenzoxamine
WO1992001686A1 (fr) * 1990-07-26 1992-02-06 Novo Nordisk A/S Piperazines 1,4-bisubstituees
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061453A1 (fr) * 1980-06-16 1982-10-06 AB Ferrosan Diphenylbutyl-1-acylpiperazines
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
FR2603583B1 (fr) * 1986-09-05 1988-12-09 Andre Buzas Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant
EP0775128A1 (fr) * 1995-06-07 1997-05-28 Dade Chemistry Systems Inc. Preparations d'immunogenes et d'autres conjugues de medicaments
JP2001506978A (ja) * 1996-10-31 2001-05-29 アメリカ合衆国 置換１―［２［ビス（アリール）メトキシ］エチル］―ピペラジンおよび―ホモピペラジンのヒドロキシル化類似物の持続性放出誘導体およびそのドパミン再アップテイクの非競合的拮抗物質としての使用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194336A2 (fr) * 1985-03-11 1986-09-17 Taiyo Pharmaceutical Industry Co., Ltd. Formulation orale de mobenzoxamine
EP0194336A3 (fr) * 1985-03-11 1987-07-01 Taiyo Pharmaceutical Industry Co., Ltd. Formulation orale de mobenzoxamine
WO1992001686A1 (fr) * 1990-07-26 1992-02-06 Novo Nordisk A/S Piperazines 1,4-bisubstituees
US5177077A (en) * 1990-07-26 1993-01-05 Novo Nordisk A/S 1,4-disubstituted piperazines
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines

Also Published As

Publication number Publication date
DE2719246C2 (de) 1984-11-08
ES456988A1 (es) 1978-02-16
FR2350100B1 (fr) 1979-04-27
DE2719246A1 (de) 1977-11-10
FR2350100A1 (fr) 1977-12-02

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee