GB1529376A - Aminocyclitol antibiotics and processes therefor - Google Patents
Aminocyclitol antibiotics and processes thereforInfo
- Publication number
- GB1529376A GB1529376A GB4973/76A GB497376A GB1529376A GB 1529376 A GB1529376 A GB 1529376A GB 4973/76 A GB4973/76 A GB 4973/76A GB 497376 A GB497376 A GB 497376A GB 1529376 A GB1529376 A GB 1529376A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- resulting
- prepared
- dideoxy
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 3
- 229940088710 antibiotic agent Drugs 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 12
- 239000001257 hydrogen Substances 0.000 abstract 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 241000187722 Micromonospora echinospora Species 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 235000014633 carbohydrates Nutrition 0.000 abstract 3
- 150000001720 carbohydrates Chemical class 0.000 abstract 3
- 238000012258 culturing Methods 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 235000015097 nutrients Nutrition 0.000 abstract 3
- 241000589232 Gluconobacter oxydans Species 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000003999 cyclitols Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
- C07C49/497—Saturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX37676U MX3968E (es) | 1975-02-18 | 1976-02-18 | Procedimiento microbiologico para preparar antibioticos de aminociclitol |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/550,273 US3972930A (en) | 1975-02-18 | 1975-02-18 | Aminocyclitol antibiotics |
| US05/615,593 US3982996A (en) | 1975-09-22 | 1975-09-22 | Process for preparing aminocyclitol antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1529376A true GB1529376A (en) | 1978-10-18 |
Family
ID=27069389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4973/76A Expired GB1529376A (en) | 1975-02-18 | 1976-02-09 | Aminocyclitol antibiotics and processes therefor |
Country Status (21)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR955564A (enrdf_load_stackoverflow) * | 1946-10-24 | 1950-01-17 | ||
| RU2458931C2 (ru) * | 2006-06-02 | 2012-08-20 | Мейдзи Сейка Фарма Ко., Лтд. | Новые аминогликозидные антибиотики |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH606434A5 (enrdf_load_stackoverflow) * | 1973-08-06 | 1978-10-31 | Scherico Ltd |
-
1976
- 1976-02-09 GB GB4973/76A patent/GB1529376A/en not_active Expired
- 1976-02-13 NO NO760472A patent/NO147308C/no unknown
- 1976-02-17 IE IE311/76A patent/IE42807B1/en unknown
- 1976-02-17 FR FR7604291A patent/FR2301265A1/fr active Granted
- 1976-02-17 AU AU11177/76A patent/AU503105B2/en not_active Ceased
- 1976-02-17 IL IL49053A patent/IL49053A/xx unknown
- 1976-02-17 SE SE7601810A patent/SE7601810L/xx not_active Application Discontinuation
- 1976-02-17 GR GR50077A patent/GR60050B/el unknown
- 1976-02-17 DK DK63176A patent/DK143111C/da not_active IP Right Cessation
- 1976-02-17 CH CH193476A patent/CH617964A5/fr not_active IP Right Cessation
- 1976-02-17 CA CA245,916A patent/CA1061731A/en not_active Expired
- 1976-02-17 FI FI760387A patent/FI56026C/fi not_active IP Right Cessation
- 1976-02-17 NZ NZ180036A patent/NZ180036A/xx unknown
- 1976-02-18 ES ES445274A patent/ES445274A1/es not_active Expired
- 1976-02-18 DE DE19762606517 patent/DE2606517A1/de not_active Ceased
- 1976-02-18 PT PT64816A patent/PT64816B/pt unknown
- 1976-02-18 EG EG100/76A patent/EG12994A/xx active
- 1976-02-18 NL NL7601655A patent/NL7601655A/xx not_active Application Discontinuation
- 1976-02-18 JP JP51016876A patent/JPS51108041A/ja active Pending
- 1976-02-18 AR AR262294A patent/AR221027A1/es active
-
1977
- 1977-02-10 AR AR266507A patent/AR227266A1/es active
- 1977-02-10 AR AR266506A patent/AR217417A1/es active
- 1977-09-20 IN IN1416/CAL/77A patent/IN147046B/en unknown
-
1978
- 1978-11-01 CH CH1126678A patent/CH618214A5/fr not_active IP Right Cessation
- 1978-11-01 CH CH1126778A patent/CH618215A5/fr not_active IP Right Cessation
-
1979
- 1979-07-20 IN IN525/DEL/79A patent/IN149240B/en unknown
-
1980
- 1980-10-24 NO NO803185A patent/NO146811C/no unknown
- 1980-10-27 SE SE8007540A patent/SE8007540L/sv not_active Application Discontinuation
-
1982
- 1982-02-24 NO NO820574A patent/NO148298C/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |