GB1526235A - Preparation of pyrimidines - Google Patents

Preparation of pyrimidines

Info

Publication number
GB1526235A
GB1526235A GB42995/75A GB4299575A GB1526235A GB 1526235 A GB1526235 A GB 1526235A GB 42995/75 A GB42995/75 A GB 42995/75A GB 4299575 A GB4299575 A GB 4299575A GB 1526235 A GB1526235 A GB 1526235A
Authority
GB
United Kingdom
Prior art keywords
formula
oct
pyrimidines
preparation
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42995/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra USA Inc
Original Assignee
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceutical Products Inc
Publication of GB1526235A publication Critical patent/GB1526235A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1526235 Pyrimidine derivatives ASTRA PHARMACEUTICALS AB 20 Oct 1975 [21 Oct 1974] 42995/75 Heading C2C Compounds of Formula I may be prepared by reacting 2,4-diamino-6- hydroxypyrimidine with 3,4,5 - trimethoxybenzaldehyde in a solvent to form an intermediate reaction product of probable formula followed by reduction of the above intermediate product. When the first reaction step is carried out in the presence of water, the intermediate is obtained in the form of a complex of formula
GB42995/75A 1974-10-21 1975-10-20 Preparation of pyrimidines Expired GB1526235A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7413202A SE400077B (en) 1974-10-21 1974-10-21 A PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5 (3 ', 4', 5 ', - TRIMETHOXYBENZYL) -PYRIMIDINE

Publications (1)

Publication Number Publication Date
GB1526235A true GB1526235A (en) 1978-09-27

Family

ID=20322479

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42995/75A Expired GB1526235A (en) 1974-10-21 1975-10-20 Preparation of pyrimidines

Country Status (13)

Country Link
JP (1) JPS5165776A (en)
AT (1) AT343122B (en)
BE (1) BE834694A (en)
CH (1) CH599168A5 (en)
DE (1) DE2546510A1 (en)
DK (1) DK135375B (en)
FI (1) FI752900A (en)
FR (1) FR2299326A1 (en)
GB (1) GB1526235A (en)
LU (1) LU73620A1 (en)
NL (1) NL7512341A (en)
NO (1) NO753480L (en)
SE (1) SE400077B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3365869D1 (en) * 1982-07-30 1986-10-09 Smith Kline French Lab Amino pyrimidinones and their preparation

Also Published As

Publication number Publication date
JPS5165776A (en) 1976-06-07
FR2299326B1 (en) 1978-10-13
AT343122B (en) 1978-05-10
DK465375A (en) 1976-04-22
BE834694A (en) 1976-04-21
FI752900A (en) 1976-04-22
SE7413202L (en) 1976-04-22
DE2546510A1 (en) 1976-04-29
LU73620A1 (en) 1976-08-19
DK135375B (en) 1977-04-18
DK135375C (en) 1977-10-17
NL7512341A (en) 1976-04-23
NO753480L (en) 1976-04-22
FR2299326A1 (en) 1976-08-27
ATA788475A (en) 1977-09-15
CH599168A5 (en) 1978-05-12
SE400077B (en) 1978-03-13

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed