GB1525845A - 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones - Google Patents

1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones

Info

Publication number
GB1525845A
GB1525845A GB31846/76A GB3184676A GB1525845A GB 1525845 A GB1525845 A GB 1525845A GB 31846/76 A GB31846/76 A GB 31846/76A GB 3184676 A GB3184676 A GB 3184676A GB 1525845 A GB1525845 A GB 1525845A
Authority
GB
United Kingdom
Prior art keywords
alkyl
carbon atoms
acetamidoalkyl
july
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31846/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB31846/76A priority Critical patent/GB1525845A/en
Priority to NL7708275A priority patent/NL7708275A/xx
Priority to DE2733868A priority patent/DE2733868C2/de
Priority to BE1008302A priority patent/BE857191A/xx
Priority to FR7723370A priority patent/FR2359826A1/fr
Priority to US05/819,279 priority patent/US4080449A/en
Priority to JP9054777A priority patent/JPS5318591A/ja
Publication of GB1525845A publication Critical patent/GB1525845A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB31846/76A 1976-07-30 1976-07-30 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones Expired GB1525845A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB31846/76A GB1525845A (en) 1976-07-30 1976-07-30 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
NL7708275A NL7708275A (nl) 1976-07-30 1977-07-26 Werkwijze voor het bereiden van nieuwe 1.2.4.5.- -tetrahydro-3h-2-benzazepine-3-onen.
DE2733868A DE2733868C2 (de) 1976-07-30 1977-07-27 Neue 1,2,4,5-Tetrahydro-3H-2-benzazepin-3-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BE1008302A BE857191A (fr) 1976-07-30 1977-07-27 Nouvelles 1,2,4,5-tetrahydro-3h-2-benzazepine-3-ones
FR7723370A FR2359826A1 (fr) 1976-07-30 1977-07-27 Nouvelles 1,2,4,5-tetrahydro-3h-2-benzazepine-3-ones
US05/819,279 US4080449A (en) 1976-07-30 1977-07-27 1,2,4,5-Tetrahydro-3H-2-benzazepin-3-ones
JP9054777A JPS5318591A (en) 1976-07-30 1977-07-29 1*2*4*55tetrahydroo3hh22 benzazepine 33one derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31846/76A GB1525845A (en) 1976-07-30 1976-07-30 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones

Publications (1)

Publication Number Publication Date
GB1525845A true GB1525845A (en) 1978-09-20

Family

ID=10329274

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31846/76A Expired GB1525845A (en) 1976-07-30 1976-07-30 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones

Country Status (7)

Country Link
US (1) US4080449A (enExample)
JP (1) JPS5318591A (enExample)
BE (1) BE857191A (enExample)
DE (1) DE2733868C2 (enExample)
FR (1) FR2359826A1 (enExample)
GB (1) GB1525845A (enExample)
NL (1) NL7708275A (enExample)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
JPS575689A (en) * 1980-06-13 1982-01-12 Toray Ind Inc Unit for microcarrier cultivation
JPS57132877A (en) * 1981-02-12 1982-08-17 Hitachi Ltd High-viscosity cultivation device
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
JP2871811B2 (ja) * 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
WO1993016103A1 (en) * 1992-02-14 1993-08-19 Merrell Dow Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU669364B2 (en) * 1992-05-15 1996-06-06 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido pyridazo(1,2)pyridazine, pyrazolo(1,2)pyridazine, pyridazo(1,2-a)(1,2)diazepine and pyrazolo(1,2-a)(1,2)diazepine derivatives useful as inhibitors of enkephalinase and ace
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) * 1992-10-30 2001-03-13 Gary A. Flynn Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
ES2131806T3 (es) * 1994-02-14 1999-08-01 Merrell Pharma Inc Nuevos derivados de disulfuro de mercaptoacetilamida utiles como inhibidores de encefalinasa y ace.
HUT74385A (en) * 1994-02-14 1996-12-30 Merrell Pharma Inc Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
HUT75160A (en) * 1994-03-24 1997-04-28 Merrell Pharma Inc Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP2003513958A (ja) * 1999-11-09 2003-04-15 イーライ・リリー・アンド・カンパニー β−アミロイドペプチド放出および／またはその合成を阻害するために有用なβ−アミノ酸化合物
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
KR100408919B1 (ko) * 2001-06-25 2003-12-11 바이오네스트 주식회사 에피나스틴 염산염의 중간체인 2,6-모르판트리돈의 새로운제조방법
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
ZA200800440B (en) * 2005-07-15 2009-12-30 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP5098011B2 (ja) * 2006-11-20 2012-12-12 国立大学法人山口大学 創傷治癒促進剤
CN102796044A (zh) * 2012-08-24 2012-11-28 南通大学 2,3,4,5-四氢-1h-2-苯并氮杂卓-1-酮衍生物的化学合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1472930A (fr) 1965-04-02 1967-03-17 Alphachimie Nouveaux dérivés de la 2, 3, 4, 5-tétrahydro-(1eta)-2-benzazépine et leurs procédés de fabrication

Also Published As

Publication number Publication date
NL7708275A (nl) 1978-02-01
DE2733868A1 (de) 1978-02-02
US4080449A (en) 1978-03-21
DE2733868C2 (de) 1987-05-14
FR2359826A1 (fr) 1978-02-24
BE857191A (fr) 1978-01-27
JPS5318591A (en) 1978-02-20
JPS6144866B2 (enExample) 1986-10-04
FR2359826B1 (enExample) 1980-04-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee