GB1524574A - Process for the manufacture of prostaglandins - Google Patents

Process for the manufacture of prostaglandins

Info

Publication number
GB1524574A
GB1524574A GB3192875A GB3192875A GB1524574A GB 1524574 A GB1524574 A GB 1524574A GB 3192875 A GB3192875 A GB 3192875A GB 3192875 A GB3192875 A GB 3192875A GB 1524574 A GB1524574 A GB 1524574A
Authority
GB
United Kingdom
Prior art keywords
3alpha
6alpha
5alpha
cyclopenta
enyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3192875A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB3192875A priority Critical patent/GB1524574A/en
Priority to IN1153/CAL/76A priority patent/IN143632B/en
Priority to PT65303A priority patent/PT65303B/en
Priority to AU15481/76A priority patent/AU509048B2/en
Priority to CA256,385A priority patent/CA1089452A/en
Priority to DK322976A priority patent/DK322976A/en
Priority to CS477576A priority patent/CS190545B2/en
Priority to FI762096A priority patent/FI762096A/fi
Priority to DE19762633559 priority patent/DE2633559A1/en
Priority to AT554076A priority patent/AT356300B/en
Priority to EG76462A priority patent/EG12287A/en
Priority to SE7608567A priority patent/SE7608567L/en
Priority to YU01874/76A priority patent/YU187476A/en
Priority to FR7623197A priority patent/FR2319630A1/en
Priority to CH972376A priority patent/CH621774A5/en
Priority to DD194122A priority patent/DD127111A5/xx
Priority to NO762641A priority patent/NO146908C/en
Priority to PH18732A priority patent/PH14977A/en
Priority to HU76IE751A priority patent/HU175101B/en
Priority to ES450311A priority patent/ES450311A1/en
Priority to JP51091187A priority patent/JPS5227749A/en
Publication of GB1524574A publication Critical patent/GB1524574A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1524574 Silylated prostaglandin precursors IMPERIAL CHEMICAL INDUSTRIES Ltd 22 June 1976 [30 July 1975] 31928/75 Heading C3S [Also in Division C2] 4# - [4 - (3 - Chlorophenoxy) - 3alpha - hydroxybuttrans - 1 - enyl] - 3,3alpha#,4,5,6,6alpha# - hexahydro- 5alpha - trimethylsilyloxy - 2H - cyclopenta[b]- furan-2-ol is prepared by reducing 4#-[4-(3- chlorophenoxy) - 3alpha - hydroxybut - trans - 1 - enyl] - 3,3alpha#,4,5,5,6alpha# - hexahydro - 5alpha - trimethylsilyloxy - 2H - cyclopenta[b]furan - 2 - one, obtained by reducing 4#-[4-(3-chlorophenoxy-3-oxobut - trans 1 - enyl] - 3,3alpha#,4,- 5,6,6alpha# - hexahydro - 5alpha - trimethylsilyloxy- 2H - cyclopenta[b]furan - 2 - one, which is made by reacting 4# - [4 - (3 - chloropophenoxy)- 3 - oxobut - trans 1 - enyl] - 3,3alpha#, 4,5,6,6alpha#- hexahydro - 5alpha - hydroxy - 2H - cyclopenta[b]- furan-2-one with hexamethyldisilazone and trimethylchlorosilane. 4# - (4 - (3 - Chlorophenoxy) - 3alpha - trimethylsilyloxybut - trans - 1 - enyl] - 3,3alpha#,4,5,6,6alpha#- hexahydro - 5alpha - trimethyl - silyloxy - 2H - cyclopenta[b]furan - 2 - ol is prepared by reducing 4# - [4 - (3 - chlorophenoxy) - 3alpha - trimethylsilyloxybut - trans - 1 - enyl] - 3,3alpha#,4,5,- 6,6alpha# - hexahydro - 5alpha - trimethylsilyloxy - 2H- cyclopenta[b]furan - 2 - one, resulting from the reaction between 4# - [4 - (3 - chlorophenoxy- 3alpha - hydroxybut - trans 1 - enyl] - 3,3alpha#,4,5,- 6,6alpha# - hexahydro - 5alpha - hydroxy - 2H - cyclopenta[b]furan - 2 - one, hexamethyldisilazane and trimethylchlorosilane. Reference has been directed by the Comptroller to Specifications 1,040,544, 1,285,372, 1,350,971, 1,372,541, 1,392,991, 1,398,838, 1,409,841 and 1,428,137.
GB3192875A 1975-07-30 1975-07-30 Process for the manufacture of prostaglandins Expired GB1524574A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GB3192875A GB1524574A (en) 1975-07-30 1975-07-30 Process for the manufacture of prostaglandins
IN1153/CAL/76A IN143632B (en) 1975-07-30 1976-06-29
PT65303A PT65303B (en) 1975-07-30 1976-07-01 Chemical process
AU15481/76A AU509048B2 (en) 1975-07-30 1976-07-01 Manufacture off-type Prostaglandins and Analogues
CA256,385A CA1089452A (en) 1975-07-30 1976-07-06 Process for the manufacture of prostaglandins of the f series
DK322976A DK322976A (en) 1975-07-30 1976-07-16 PROCEDURE FOR THE PRODUCTION OF PROSTAGLANDINS OR PROSTAGLAND-LIKE COMPOUNDS
CS477576A CS190545B2 (en) 1975-07-30 1976-07-19 Method of producing derivatives of prostaglandin
FI762096A FI762096A (en) 1975-07-30 1976-07-21
DE19762633559 DE2633559A1 (en) 1975-07-30 1976-07-26 METHOD OF MANUFACTURING PROSTAGLANDINES
AT554076A AT356300B (en) 1975-07-30 1976-07-28 METHOD FOR PRODUCING PROSTAGLANDINES
EG76462A EG12287A (en) 1975-07-30 1976-07-28 Process for preparing of prostaglandins
SE7608567A SE7608567L (en) 1975-07-30 1976-07-29 PROCEDURE FOR PRODUCTION OF PROSTAGLANDINS
YU01874/76A YU187476A (en) 1975-07-30 1976-07-29 Process for preparing prostaglandine derivatives
FR7623197A FR2319630A1 (en) 1975-07-30 1976-07-29 PROCESS FOR PREPARING A PROSTAG
CH972376A CH621774A5 (en) 1975-07-30 1976-07-29 Process for the preparation of prostaglandins.
DD194122A DD127111A5 (en) 1975-07-30 1976-07-29
NO762641A NO146908C (en) 1975-07-30 1976-07-29 PROCEDURE FOR THE PREPARATION OF PROSTAGLANDIN F2ALFA AND ANALOGS THEREOF.
PH18732A PH14977A (en) 1975-07-30 1976-07-29 An improved process for preparing prostaglandin f 2 alpha and analogues thereof
HU76IE751A HU175101B (en) 1975-07-30 1976-07-30 Process for preparing prostaglandins and prostaglandin-like compounds
ES450311A ES450311A1 (en) 1975-07-30 1976-07-30 Process for the manufacture of prostaglandins
JP51091187A JPS5227749A (en) 1975-07-30 1976-07-30 Process for manufacture of prostaglandins or prostaglandinnanalog compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3192875A GB1524574A (en) 1975-07-30 1975-07-30 Process for the manufacture of prostaglandins

Publications (1)

Publication Number Publication Date
GB1524574A true GB1524574A (en) 1978-09-13

Family

ID=10330488

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3192875A Expired GB1524574A (en) 1975-07-30 1975-07-30 Process for the manufacture of prostaglandins

Country Status (5)

Country Link
CS (1) CS190545B2 (en)
ES (1) ES450311A1 (en)
GB (1) GB1524574A (en)
HU (1) HU175101B (en)
PH (1) PH14977A (en)

Also Published As

Publication number Publication date
PH14977A (en) 1982-02-26
CS190545B2 (en) 1979-05-31
HU175101B (en) 1980-05-28
ES450311A1 (en) 1977-11-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee