GB1510617A - 16-methyl-9alpha-halo steroid esters and ethers and preparation thereof - Google Patents

16-methyl-9alpha-halo steroid esters and ethers and preparation thereof

Info

Publication number
GB1510617A
GB1510617A GB12608/75A GB1260875A GB1510617A GB 1510617 A GB1510617 A GB 1510617A GB 12608/75 A GB12608/75 A GB 12608/75A GB 1260875 A GB1260875 A GB 1260875A GB 1510617 A GB1510617 A GB 1510617A
Authority
GB
United Kingdom
Prior art keywords
ethers
methyl
tetrahydropyran
acyloxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12608/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plurichemie Anstalt
Original Assignee
Plurichemie Anstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plurichemie Anstalt filed Critical Plurichemie Anstalt
Publication of GB1510617A publication Critical patent/GB1510617A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB12608/75A 1974-03-27 1975-03-26 16-methyl-9alpha-halo steroid esters and ethers and preparation thereof Expired GB1510617A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT6163774 1974-03-27
PT6163674 1974-03-27
PT6163675 1975-03-10

Publications (1)

Publication Number Publication Date
GB1510617A true GB1510617A (en) 1978-05-10

Family

ID=27354092

Family Applications (2)

Application Number Title Priority Date Filing Date
GB12608/75A Expired GB1510617A (en) 1974-03-27 1975-03-26 16-methyl-9alpha-halo steroid esters and ethers and preparation thereof
GB47940/77A Expired GB1511820A (en) 1974-03-27 1975-03-26 16-methyl-9alpha-halo steroid ethers and esters and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB47940/77A Expired GB1511820A (en) 1974-03-27 1975-03-26 16-methyl-9alpha-halo steroid ethers and esters and their preparation

Country Status (8)

Country Link
BE (1) BE827275A (da)
CH (2) CH622811A5 (da)
DK (1) DK153556C (da)
FR (1) FR2274309A1 (da)
GB (2) GB1510617A (da)
IE (2) IE41138B1 (da)
NZ (1) NZ177056A (da)
SE (1) SE440656B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
CN102516348B (zh) * 2011-11-10 2013-11-13 中国科学院上海有机化学研究所 一种16s-甲基-20s-羟基孕甾化合物、合成方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1070751A (en) * 1964-01-28 1967-06-01 Glaxo Lab Ltd 17-esters of 17-hydroxy-21-desoxy-steroids
GB1139505A (en) * 1965-06-23 1969-01-08 Glaxo Lab Ltd A process for the production of 17-‡-monoesters of 17-‡-hydroxy-20-keto-steroids
US3383394A (en) * 1965-08-30 1968-05-14 Schering Corp Novel 17-acylating process and products thereof
CH481085A (de) * 1965-08-30 1969-11-15 Scherico Ltd Verfahren zur Herstellung von 11B-Hydroxy-17 -alkanoyloxysteroiden der Pregnanreihe
BE788355A (fr) * 1971-09-07 1973-03-05 Merck Patent Gmbh Esters de 9 alpha-fluoro-16-methylene-prednisolone

Also Published As

Publication number Publication date
FR2274309B1 (da) 1978-11-24
IE41137L (en) 1975-09-27
GB1511820A (en) 1978-05-24
SE440656B (sv) 1985-08-12
CH625254A5 (da) 1981-09-15
DK153556B (da) 1988-07-25
DK129575A (da) 1975-09-28
CH622811A5 (da) 1981-04-30
IE41137B1 (en) 1979-10-24
FR2274309A1 (fr) 1976-01-09
IE41138B1 (en) 1979-10-24
SE7803041L (sv) 1978-03-16
BE827275A (fr) 1975-07-16
NZ177056A (en) 1978-09-20
DK153556C (da) 1988-12-05

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19950325