GB1508018A - Radioimmunoassay for determining the digoxin content of a sample - Google Patents
Radioimmunoassay for determining the digoxin content of a sampleInfo
- Publication number
- GB1508018A GB1508018A GB35117/75A GB3511775A GB1508018A GB 1508018 A GB1508018 A GB 1508018A GB 35117/75 A GB35117/75 A GB 35117/75A GB 3511775 A GB3511775 A GB 3511775A GB 1508018 A GB1508018 A GB 1508018A
- Authority
- GB
- United Kingdom
- Prior art keywords
- digoxigenin
- acetyl
- radioimmunoassay
- sample
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title 1
- 229960005156 digoxin Drugs 0.000 title 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title 1
- 238000003127 radioimmunoassay Methods 0.000 title 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 abstract 3
- -1 4 - hydroxyphenethylcarbamoyl Chemical group 0.000 abstract 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical class C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229960003732 tyramine Drugs 0.000 abstract 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/505,185 US3981982A (en) | 1974-09-11 | 1974-09-11 | Radioimmunoassay for determining the digoxin content of a sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1508018A true GB1508018A (en) | 1978-04-19 |
Family
ID=24009363
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35117/75A Expired GB1508018A (en) | 1974-09-11 | 1975-08-26 | Radioimmunoassay for determining the digoxin content of a sample |
| GB20309/77A Expired GB1508019A (en) | 1974-09-11 | 1975-08-26 | 3-o-chloroformyl-12-o-acetyldigoxigenin and process for the production thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20309/77A Expired GB1508019A (en) | 1974-09-11 | 1975-08-26 | 3-o-chloroformyl-12-o-acetyldigoxigenin and process for the production thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3981982A (https=) |
| CA (1) | CA1036592A (https=) |
| DE (1) | DE2539242A1 (https=) |
| FR (1) | FR2285613A1 (https=) |
| GB (2) | GB1508018A (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4255329A (en) * | 1973-10-02 | 1981-03-10 | Syva Company | Double receptor fluorescent immunoassay |
| GB1553222A (en) * | 1975-05-07 | 1979-09-26 | Steele Chemical Co Ltd | 14 - hydroxy 3- eoxycardenolides |
| DE2537129C3 (de) | 1975-08-20 | 1978-05-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reaktive unsymmetrische, einen Digoxin- bzw. Digitoxinrest enthaltende Dicarbonsäureester, Verfahren zu deren Herstellung sowie ihre Verwendung zur Herstellung von Testreagentien |
| US4181650A (en) * | 1975-08-25 | 1980-01-01 | Maier Charles L Jr | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
| US4115539A (en) * | 1976-05-17 | 1978-09-19 | Union Carbide Corporation | Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives |
| US4221725A (en) * | 1977-08-12 | 1980-09-09 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| US4184849A (en) * | 1977-12-05 | 1980-01-22 | Technicon Instruments Corporation | Mixed agglutination |
| US4345096A (en) * | 1979-01-17 | 1982-08-17 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| DE3026665A1 (de) * | 1980-07-14 | 1982-02-11 | Hoechst Ag, 6000 Frankfurt | Verfahren zum binden und trennen fuer den kompetitiven radioimmunoassay und reagenz hierzu |
| DD152424A1 (de) * | 1980-07-30 | 1981-11-25 | Manfred Ziegler | Verfahren zur trennung des freien und antikoerpergebundenen liganden fuer labelled-ligand-immunoassays |
| WO1983004102A1 (en) * | 1982-05-07 | 1983-11-24 | Paragon Diagnostics | Competitive immunofluorescence assay and test kit |
| JPS59500832A (ja) * | 1982-05-07 | 1984-05-10 | パラゴン・ダイアグノスティクス・インコ−ポレイテッド | 競合的免疫螢光検定法及び試験セット |
| US4654311A (en) * | 1984-06-15 | 1987-03-31 | Syntex (U.S.A.) Inc. | Serum pretreatment for digoxin assay |
| EP0933355A1 (en) * | 1997-12-24 | 1999-08-04 | Universiteit Maastricht | Preparation of tyramide conjugates |
| ES2857626T3 (es) * | 2010-01-15 | 2021-09-29 | Suzhou Neupharma Co Ltd | Ciertas entidades químicas, composiciones y métodos |
| CN102656179B (zh) | 2010-08-28 | 2015-07-29 | 苏州润新生物科技有限公司 | 蟾蜍灵衍生物、其药物组合物及用途 |
| US9493503B2 (en) * | 2011-02-02 | 2016-11-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2013165924A1 (en) | 2012-04-29 | 2013-11-07 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH459997A (de) * | 1963-12-05 | 1968-07-31 | Shalom Prof Sarel | Verfahren zur Herstellung von Cardenoliden |
-
1974
- 1974-09-11 US US05/505,185 patent/US3981982A/en not_active Expired - Lifetime
-
1975
- 1975-08-26 GB GB35117/75A patent/GB1508018A/en not_active Expired
- 1975-08-26 GB GB20309/77A patent/GB1508019A/en not_active Expired
- 1975-08-26 CA CA234,197A patent/CA1036592A/en not_active Expired
- 1975-09-03 DE DE19752539242 patent/DE2539242A1/de active Pending
- 1975-09-10 FR FR7527794A patent/FR2285613A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| US3981982A (en) | 1976-09-21 |
| CA1036592A (en) | 1978-08-15 |
| FR2285613A1 (fr) | 1976-04-16 |
| AU8430775A (en) | 1977-03-03 |
| DE2539242A1 (de) | 1976-04-01 |
| GB1508019A (en) | 1978-04-19 |
| FR2285613B1 (https=) | 1981-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |