GB1499823A - 3,20-dione-1,4,9(11)-triene steroids - Google Patents
3,20-dione-1,4,9(11)-triene steroidsInfo
- Publication number
- GB1499823A GB1499823A GB3146177A GB3146177A GB1499823A GB 1499823 A GB1499823 A GB 1499823A GB 3146177 A GB3146177 A GB 3146177A GB 3146177 A GB3146177 A GB 3146177A GB 1499823 A GB1499823 A GB 1499823A
- Authority
- GB
- United Kingdom
- Prior art keywords
- effected
- epoxide
- feb
- july
- vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1499823 2 - Bromo - 6# - fluoro - #<SP>1,4,9(11)</SP> pregnatrienes PIEFFEL SpA 6 Feb 1975 [27 Feb 1974 5 July 1974 25 July 1974 19 Nov 1974] 31461/77 31462/77 31463/77 and 31464/77- Divided out of 1499822 Heading C2U Novel steroids of the formula (wherein R 3 is H or α- or #-CH 3 ) are prepared as illustrated in the following reaction scheme wherein Ac is acetyl and MS is mesyl. The epoxidation step produces some 5#,6#-epoxide, from which the required 5α,6α-epoxide is separated by crystallization. (III) is converted to (IV) using HF; (IV)#(V) is a buffered bromination; (VI)#(VII) is effected with acetic anhydride and perchloric acid; (VII)#(VIIa) is effected using Br 2 in acetic acid containing sodium or potassium acetate; and the dehydrobromination to produce the required products is effected using a metal halide, e.g. LiCl, and Br 2 in hot DMF or other amide solvent, or an excess of Li 2 CO 3 in DMF.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3146177A GB1499823A (en) | 1975-02-06 | 1975-02-06 | 3,20-dione-1,4,9(11)-triene steroids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3146177A GB1499823A (en) | 1975-02-06 | 1975-02-06 | 3,20-dione-1,4,9(11)-triene steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1499823A true GB1499823A (en) | 1978-02-01 |
Family
ID=10323434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3146177A Expired GB1499823A (en) | 1975-02-06 | 1975-02-06 | 3,20-dione-1,4,9(11)-triene steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1499823A (en) |
-
1975
- 1975-02-06 GB GB3146177A patent/GB1499823A/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |