GB1492837A - Insulin preparations having antidiabetic activity and process for their manufacture - Google Patents
Insulin preparations having antidiabetic activity and process for their manufactureInfo
- Publication number
- GB1492837A GB1492837A GB14079/75A GB1407975A GB1492837A GB 1492837 A GB1492837 A GB 1492837A GB 14079/75 A GB14079/75 A GB 14079/75A GB 1407975 A GB1407975 A GB 1407975A GB 1492837 A GB1492837 A GB 1492837A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- manufacture
- insulin preparations
- zinc ion
- phenylalanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 17
- 229940125396 insulin Drugs 0.000 title abstract 9
- 102000004877 Insulin Human genes 0.000 title abstract 7
- 108090001061 Insulin Proteins 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title abstract 4
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 4
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2418218A DE2418218A1 (de) | 1974-04-13 | 1974-04-13 | Neue arzneimittel-zubereitung mit antidiabetischer wirkung |
| DE19742459515 DE2459515C3 (de) | 1974-12-17 | 1974-12-17 | Arzneimittelzubereitungen mit antidiabetischer Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1492837A true GB1492837A (en) | 1977-11-23 |
Family
ID=25766977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14079/75A Expired GB1492837A (en) | 1974-04-13 | 1975-04-07 | Insulin preparations having antidiabetic activity and process for their manufacture |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028587A (en) * | 1987-05-22 | 1991-07-02 | Hoechst Aktiengesellschaft | Mixed crystals of insulin and insulin derivatives |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1560232A (en) * | 1977-02-01 | 1980-01-30 | Novo Industri As | Biphasic insulin preparations comprising crystalline insulin and monodesamido insulin |
| DE69627340T2 (de) | 1995-07-25 | 2004-02-05 | Novartis Ag | Transformierenden waeckstumsfaktor beta krystalle |
-
1975
- 1975-03-31 EG EG178/75A patent/EG12098A/xx active
- 1975-04-07 IL IL47043A patent/IL47043A/xx unknown
- 1975-04-07 GB GB14079/75A patent/GB1492837A/en not_active Expired
- 1975-04-08 NL NL7504165A patent/NL7504165A/xx not_active Application Discontinuation
- 1975-04-08 ES ES436398A patent/ES436398A1/es not_active Expired
- 1975-04-10 FI FI751084A patent/FI751084A7/fi not_active Application Discontinuation
- 1975-04-11 AU AU80073/75A patent/AU500430B2/en not_active Expired
- 1975-04-11 CA CA224,590A patent/CA1047919A/en not_active Expired
- 1975-04-11 LU LU72269A patent/LU72269A1/xx unknown
- 1975-04-11 IE IE832/75A patent/IE40985B1/xx unknown
- 1975-04-14 FR FR7511535A patent/FR2267116B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028587A (en) * | 1987-05-22 | 1991-07-02 | Hoechst Aktiengesellschaft | Mixed crystals of insulin and insulin derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2267116B1 (enrdf_load_stackoverflow) | 1978-10-06 |
| FI751084A7 (enrdf_load_stackoverflow) | 1975-10-14 |
| ES436398A1 (es) | 1977-05-01 |
| NL7504165A (nl) | 1975-10-15 |
| IE40985B1 (en) | 1979-09-26 |
| CA1047919A (en) | 1979-02-06 |
| FR2267116A1 (enrdf_load_stackoverflow) | 1975-11-07 |
| LU72269A1 (enrdf_load_stackoverflow) | 1977-02-03 |
| IL47043A0 (en) | 1975-06-25 |
| IE40985L (en) | 1975-10-13 |
| AU500430B2 (en) | 1979-05-24 |
| AU8007375A (en) | 1976-10-14 |
| IL47043A (en) | 1978-06-15 |
| EG12098A (en) | 1980-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |