GB1490659A - Quinuclidin-3-yl carbinols - Google Patents
Quinuclidin-3-yl carbinolsInfo
- Publication number
- GB1490659A GB1490659A GB587775A GB587775A GB1490659A GB 1490659 A GB1490659 A GB 1490659A GB 587775 A GB587775 A GB 587775A GB 587775 A GB587775 A GB 587775A GB 1490659 A GB1490659 A GB 1490659A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- quinuclidin
- carbinols
- formula
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUAWHSHTXVVCLZ-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-ylmethanol Chemical class C1CC2C(CO)CN1CC2 GUAWHSHTXVVCLZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003326 anti-histaminergic effect Effects 0.000 abstract 1
- 230000001705 anti-serotonergic effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000003420 antiserotonin agent Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 150000002900 organolithium compounds Chemical class 0.000 abstract 1
- 150000002901 organomagnesium compounds Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU2002003A SU495310A1 (ru) | 1974-03-05 | 1974-03-05 | Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1490659A true GB1490659A (en) | 1977-11-02 |
Family
ID=20577613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB587775A Expired GB1490659A (en) | 1974-03-05 | 1975-02-12 | Quinuclidin-3-yl carbinols |
Country Status (5)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006029549A1 (fr) | 2004-09-15 | 2006-03-23 | Shuqiang Zhao | Composes de quinuclidine a groupe ammonium quaternaire, procede d'elaboration et utilisation comme agents de blocage de l'acetycholine |
| WO2013043961A1 (en) * | 2011-09-22 | 2013-03-28 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of choline kinase |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125531A (en) * | 1977-04-18 | 1978-11-14 | G. D. Searle & Co. | 2-Substituted-1-azabicyclo[2.2.2]octanes |
| US4203989A (en) * | 1979-04-30 | 1980-05-20 | G. D. Searle & Co. | Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds |
| CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
| ES2061502T3 (es) * | 1986-06-27 | 1994-12-16 | Beecham Group Plc | Nuevos n-heterociclos biciclicos puenteados. |
| GB9122988D0 (en) * | 1991-10-30 | 1991-12-18 | Ici Plc | Heterocyclic compounds |
| WO1993021184A1 (en) * | 1992-04-10 | 1993-10-28 | Zeneca Limited | Biphenylylquinuclidine derivatives as squalene synthase inhibitors |
| GB9211796D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Heterocyclic derivatives |
| GB9216721D0 (en) * | 1992-08-06 | 1992-09-23 | Ici Plc | Therapeutic heterocyclic derivatives |
| GB9218334D0 (en) * | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
| GB9226573D0 (en) * | 1992-12-21 | 1993-02-17 | Ici Plc | Heterocyclic compounds |
| PL183933B1 (pl) * | 1994-08-24 | 2002-08-30 | Astra Ab | Związki spiroazabicyklo, sposób wytwarzania związku spiroazabicyklo i kompozycja farmaceutyczna |
| BR0313153A (pt) * | 2002-08-14 | 2005-06-28 | Neurosearch As | Derivado de quinuclidina, composição farmacêutica, uso de um derivado de quinuclidina, e, método de tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição de um corpo animal vivo |
-
1974
- 1974-03-05 SU SU2002003A patent/SU495310A1/ru active
-
1975
- 1975-01-24 DE DE19752502916 patent/DE2502916A1/de active Granted
- 1975-02-12 GB GB587775A patent/GB1490659A/en not_active Expired
- 1975-03-03 FR FR7506586A patent/FR2262985B1/fr not_active Expired
- 1975-03-05 CH CH277975A patent/CH608015A5/xx not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006029549A1 (fr) | 2004-09-15 | 2006-03-23 | Shuqiang Zhao | Composes de quinuclidine a groupe ammonium quaternaire, procede d'elaboration et utilisation comme agents de blocage de l'acetycholine |
| EP1790643A4 (en) * | 2004-09-15 | 2008-09-24 | Shuqiang Zhao | QUATERNARY AMMONIUM GROUP QUINUCLIDINE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND USE AS ACETYCHOLINE BLOCKING AGENTS |
| WO2013043961A1 (en) * | 2011-09-22 | 2013-03-28 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of choline kinase |
| CN103814026A (zh) * | 2011-09-22 | 2014-05-21 | 沃泰克斯药物股份有限公司 | 可用作胆碱激酶抑制剂的化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| SU495310A1 (ru) | 1975-12-15 |
| FR2262985B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-12-01 |
| CH608015A5 (en) | 1978-12-15 |
| DE2502916A1 (de) | 1975-09-11 |
| DE2502916C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-03-17 |
| FR2262985A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |