IE44614L - Heterocyclylcarbonylpiperazinylquinazolines - Google Patents
HeterocyclylcarbonylpiperazinylquinazolinesInfo
- Publication number
- IE44614L IE44614L IE770338A IE33877A IE44614L IE 44614 L IE44614 L IE 44614L IE 770338 A IE770338 A IE 770338A IE 33877 A IE33877 A IE 33877A IE 44614 L IE44614 L IE 44614L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- prazosin
- products
- image
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The compounds of the formula I are obtained by reacting compounds of the formula II with a reagent of the formula <IMAGE> in which the substituents have the meaning given in Patent Claim 1. The products which are obtained exhibit an anti-hypertensive effect which is comparable with that of prazosin; however, the peripheral alpha -adrenergic blocking effect of the products is in general much smaller than that of prazosin. <IMAGE>
[GB1533529A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/658,961 US4001237A (en) | 1976-02-18 | 1976-02-18 | Oxazole, isoxazole, thiazole and isothiazole amides |
| US05/658,979 US4001238A (en) | 1976-02-18 | 1976-02-18 | 1,3,4-oxadiazole amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44614L true IE44614L (en) | 1977-08-18 |
| IE44614B1 IE44614B1 (en) | 1982-01-27 |
Family
ID=27097727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE338/77A IE44614B1 (en) | 1976-02-18 | 1977-02-17 | 4-amino-6,7-dimethoxy-2-(4-(heterocyclylcarbonyl) piperazin-1-yl) quinazolines |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS584716B2 (en) |
| CA (1) | CA1081228A (en) |
| CH (1) | CH635838A5 (en) |
| CY (1) | CY1122A (en) |
| DE (1) | DE2707067A1 (en) |
| DK (1) | DK65177A (en) |
| FI (1) | FI770485A (en) |
| FR (1) | FR2348924A1 (en) |
| GB (1) | GB1533529A (en) |
| IE (1) | IE44614B1 (en) |
| KE (1) | KE3155A (en) |
| LU (1) | LU76802A1 (en) |
| MY (1) | MY8200110A (en) |
| NL (1) | NL7701753A (en) |
| SE (1) | SE7701732L (en) |
| YU (4) | YU45477A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5791987A (en) * | 1980-11-26 | 1982-06-08 | Sankyo Co Ltd | Aminoquinazoline derivative and its preparation |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| EP1517898A1 (en) * | 2002-06-29 | 2005-03-30 | Zentaris GmbH | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases |
-
1977
- 1977-02-15 FI FI770485A patent/FI770485A/fi not_active Application Discontinuation
- 1977-02-15 DK DK65177A patent/DK65177A/en not_active Application Discontinuation
- 1977-02-15 CA CA271,839A patent/CA1081228A/en not_active Expired
- 1977-02-16 SE SE7701732A patent/SE7701732L/en not_active Application Discontinuation
- 1977-02-17 CY CY1122A patent/CY1122A/en unknown
- 1977-02-17 CH CH199477A patent/CH635838A5/en not_active IP Right Cessation
- 1977-02-17 IE IE338/77A patent/IE44614B1/en unknown
- 1977-02-17 FR FR7704560A patent/FR2348924A1/en active Granted
- 1977-02-17 GB GB6704/77A patent/GB1533529A/en not_active Expired
- 1977-02-18 LU LU76802A patent/LU76802A1/xx unknown
- 1977-02-18 NL NL7701753A patent/NL7701753A/en not_active Application Discontinuation
- 1977-02-18 DE DE19772707067 patent/DE2707067A1/en not_active Withdrawn
- 1977-02-18 JP JP52016326A patent/JPS584716B2/en not_active Expired
- 1977-02-18 YU YU00454/77A patent/YU45477A/en unknown
-
1980
- 1980-10-20 YU YU02677/80A patent/YU267780A/en unknown
-
1981
- 1981-08-25 KE KE3155A patent/KE3155A/en unknown
-
1982
- 1982-07-22 YU YU01612/82A patent/YU161282A/en unknown
- 1982-07-22 YU YU01611/82A patent/YU161182A/en unknown
- 1982-12-30 MY MY110/82A patent/MY8200110A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU76802A1 (en) | 1977-09-12 |
| JPS584716B2 (en) | 1983-01-27 |
| AU2242677A (en) | 1978-07-06 |
| YU161282A (en) | 1982-10-31 |
| DE2707067A1 (en) | 1977-08-25 |
| KE3155A (en) | 1981-09-18 |
| YU267780A (en) | 1983-06-30 |
| YU161182A (en) | 1982-10-31 |
| FR2348924A1 (en) | 1977-11-18 |
| FI770485A (en) | 1977-08-19 |
| MY8200110A (en) | 1982-12-31 |
| CY1122A (en) | 1981-12-04 |
| JPS52102286A (en) | 1977-08-27 |
| FR2348924B1 (en) | 1980-05-09 |
| CA1081228A (en) | 1980-07-08 |
| YU45477A (en) | 1982-10-31 |
| CH635838A5 (en) | 1983-04-29 |
| IE44614B1 (en) | 1982-01-27 |
| GB1533529A (en) | 1978-11-29 |
| DK65177A (en) | 1977-08-19 |
| NL7701753A (en) | 1977-08-22 |
| SE7701732L (en) | 1977-08-19 |
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