SE7701732L - 1,2,3-OXADIAZOLAMIDER - Google Patents

1,2,3-OXADIAZOLAMIDER

Info

Publication number
SE7701732L
SE7701732L SE7701732A SE7701732A SE7701732L SE 7701732 L SE7701732 L SE 7701732L SE 7701732 A SE7701732 A SE 7701732A SE 7701732 A SE7701732 A SE 7701732A SE 7701732 L SE7701732 L SE 7701732L
Authority
SE
Sweden
Prior art keywords
formula
prazosin
products
image
compounds
Prior art date
Application number
SE7701732A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
R A Partyka
R R Crenshaw
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/658,961 external-priority patent/US4001237A/en
Priority claimed from US05/658,979 external-priority patent/US4001238A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7701732L publication Critical patent/SE7701732L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The compounds of the formula I are obtained by reacting compounds of the formula II with a reagent of the formula <IMAGE> in which the substituents have the meaning given in Patent Claim 1. The products which are obtained exhibit an anti-hypertensive effect which is comparable with that of prazosin; however, the peripheral alpha -adrenergic blocking effect of the products is in general much smaller than that of prazosin. <IMAGE>
SE7701732A 1976-02-18 1977-02-16 1,2,3-OXADIAZOLAMIDER SE7701732L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/658,961 US4001237A (en) 1976-02-18 1976-02-18 Oxazole, isoxazole, thiazole and isothiazole amides
US05/658,979 US4001238A (en) 1976-02-18 1976-02-18 1,3,4-oxadiazole amides

Publications (1)

Publication Number Publication Date
SE7701732L true SE7701732L (en) 1977-08-19

Family

ID=27097727

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7701732A SE7701732L (en) 1976-02-18 1977-02-16 1,2,3-OXADIAZOLAMIDER

Country Status (16)

Country Link
JP (1) JPS584716B2 (en)
CA (1) CA1081228A (en)
CH (1) CH635838A5 (en)
CY (1) CY1122A (en)
DE (1) DE2707067A1 (en)
DK (1) DK65177A (en)
FI (1) FI770485A (en)
FR (1) FR2348924A1 (en)
GB (1) GB1533529A (en)
IE (1) IE44614B1 (en)
KE (1) KE3155A (en)
LU (1) LU76802A1 (en)
MY (1) MY8200110A (en)
NL (1) NL7701753A (en)
SE (1) SE7701732L (en)
YU (4) YU45477A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5791987A (en) * 1980-11-26 1982-06-08 Sankyo Co Ltd Aminoquinazoline derivative and its preparation
US5994294A (en) * 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
WO2004002965A1 (en) * 2002-06-29 2004-01-08 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases

Also Published As

Publication number Publication date
CH635838A5 (en) 1983-04-29
GB1533529A (en) 1978-11-29
DE2707067A1 (en) 1977-08-25
JPS52102286A (en) 1977-08-27
FR2348924A1 (en) 1977-11-18
JPS584716B2 (en) 1983-01-27
DK65177A (en) 1977-08-19
IE44614B1 (en) 1982-01-27
YU161182A (en) 1982-10-31
MY8200110A (en) 1982-12-31
YU45477A (en) 1982-10-31
NL7701753A (en) 1977-08-22
CY1122A (en) 1981-12-04
YU267780A (en) 1983-06-30
KE3155A (en) 1981-09-18
LU76802A1 (en) 1977-09-12
IE44614L (en) 1977-08-18
CA1081228A (en) 1980-07-08
FI770485A (en) 1977-08-19
FR2348924B1 (en) 1980-05-09
YU161282A (en) 1982-10-31
AU2242677A (en) 1978-07-06

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