GB1490659A - Quinuclidin-3-yl carbinols - Google Patents

Quinuclidin-3-yl carbinols

Info

Publication number
GB1490659A
GB1490659A GB587775A GB587775A GB1490659A GB 1490659 A GB1490659 A GB 1490659A GB 587775 A GB587775 A GB 587775A GB 587775 A GB587775 A GB 587775A GB 1490659 A GB1490659 A GB 1490659A
Authority
GB
United Kingdom
Prior art keywords
compounds
quinuclidin
carbinols
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB587775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VNI KHIM FARMA I IM S ORDZHONI
Original Assignee
VNI KHIM FARMA I IM S ORDZHONI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VNI KHIM FARMA I IM S ORDZHONI filed Critical VNI KHIM FARMA I IM S ORDZHONI
Publication of GB1490659A publication Critical patent/GB1490659A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

(Quinuclidin-3-yl)carbinols of the formula <IMAGE> where n = 0 or 1 and R and R' = optionally substituted phenyl, cyclohexyl or heteroaryl, R and R' being identical or not identical, are obtained in one or two steps from compounds of the formula <IMAGE> where R'' = -CN or -COO(lower alkyl) by reaction with organolithium or organomagnesium compounds. The compounds (1) have antihistamine, antiserotonin and antiallergic actions in combination with decreased toxicity. At the same time, they have a pronounced long-term action.
GB587775A 1974-03-05 1975-02-12 Quinuclidin-3-yl carbinols Expired GB1490659A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU2002003A SU495310A1 (en) 1974-03-05 1974-03-05 Hinuclidyl-3-diaral (heteryl) carbinols exhibiting antihistamine, antiserotonin and antiallergic activity and a method for their preparation

Publications (1)

Publication Number Publication Date
GB1490659A true GB1490659A (en) 1977-11-02

Family

ID=20577613

Family Applications (1)

Application Number Title Priority Date Filing Date
GB587775A Expired GB1490659A (en) 1974-03-05 1975-02-12 Quinuclidin-3-yl carbinols

Country Status (5)

Country Link
CH (1) CH608015A5 (en)
DE (1) DE2502916A1 (en)
FR (1) FR2262985B1 (en)
GB (1) GB1490659A (en)
SU (1) SU495310A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006029549A1 (en) 2004-09-15 2006-03-23 Shuqiang Zhao Quinuclidine compounds having quaternary ammonium group, it's preparation method and use as blocking agents of acetycholine
WO2013043961A1 (en) * 2011-09-22 2013-03-28 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of choline kinase

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125531A (en) * 1977-04-18 1978-11-14 G. D. Searle & Co. 2-Substituted-1-azabicyclo[2.2.2]octanes
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
CH667657A5 (en) * 1985-01-07 1988-10-31 Sandoz Ag CARBOCYCLIC AND HETEROCYCLIC CARBONYL METHYLENE AND METHYL PIPERIDINE AND PYRROLIDINE.
DE3789039T2 (en) * 1986-06-27 1994-06-09 Beecham Group Plc Bridged bicyclic N-heterocyclic compounds.
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
JPH06508377A (en) * 1992-04-10 1994-09-22 ゼネカ　リミテッド heterocyclic compound
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US20050245567A1 (en) * 2002-08-14 2005-11-03 Dan Peters Novel quinuclidine derivatives and their use

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006029549A1 (en) 2004-09-15 2006-03-23 Shuqiang Zhao Quinuclidine compounds having quaternary ammonium group, it's preparation method and use as blocking agents of acetycholine
EP1790643A1 (en) * 2004-09-15 2007-05-30 Shuqiang Zhao Quinuclidine compounds having quaternary ammonium group, it's preparation method and use as blocking agents of acetycholine
EP1790643A4 (en) * 2004-09-15 2008-09-24 Shuqiang Zhao Quinuclidine compounds having quaternary ammonium group, it's preparation method and use as blocking agents of acetycholine
WO2013043961A1 (en) * 2011-09-22 2013-03-28 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of choline kinase
CN103814026A (en) * 2011-09-22 2014-05-21 沃泰克斯药物股份有限公司 Compounds useful as inhibitors of choline kinase

Also Published As

Publication number Publication date
CH608015A5 (en) 1978-12-15
SU495310A1 (en) 1975-12-15
DE2502916C2 (en) 1988-03-17
FR2262985A1 (en) 1975-10-03
FR2262985B1 (en) 1978-12-01
DE2502916A1 (en) 1975-09-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee