GB1476717A - Tretinoin in a gel vehicle for acne treatment - Google Patents
Tretinoin in a gel vehicle for acne treatmentInfo
- Publication number
- GB1476717A GB1476717A GB181076A GB181076A GB1476717A GB 1476717 A GB1476717 A GB 1476717A GB 181076 A GB181076 A GB 181076A GB 181076 A GB181076 A GB 181076A GB 1476717 A GB1476717 A GB 1476717A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tretinoin
- organic solvent
- johnson
- jan
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 title abstract 4
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract 3
- 206010000496 acne Diseases 0.000 title abstract 3
- 229960001727 tretinoin Drugs 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 abstract 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 abstract 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229940087168 alpha tocopherol Drugs 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 abstract 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 abstract 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 abstract 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 abstract 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 abstract 1
- 229940043276 diisopropanolamine Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 229930002330 retinoic acid Natural products 0.000 abstract 1
- 230000000475 sunscreen effect Effects 0.000 abstract 1
- 239000000516 sunscreening agent Substances 0.000 abstract 1
- 229960000984 tocofersolan Drugs 0.000 abstract 1
- 229940125379 topical corticosteroid Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 235000004835 α-tocopherol Nutrition 0.000 abstract 1
- 239000002076 α-tocopherol Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54190675A | 1975-01-17 | 1975-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1476717A true GB1476717A (en) | 1977-06-16 |
Family
ID=24161582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB181076A Expired GB1476717A (en) | 1975-01-17 | 1976-01-16 | Tretinoin in a gel vehicle for acne treatment |
Country Status (18)
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4214000A (en) | 1978-10-30 | 1980-07-22 | Johnson & Johnson | Zinc salt of all-trans-retinoic acid for the treatment of acne |
| EP0090378A1 (en) * | 1982-03-26 | 1983-10-05 | Eisai Co., Ltd. | Isoprenylcarboxylic acid-containing composition for external use |
| GB2128087A (en) * | 1982-10-07 | 1984-04-26 | Ciba Geigy Ag | Topically administrable anti-inflammatory pharmaceutical compositions |
| GB2268402A (en) * | 1992-06-19 | 1994-01-12 | Ian Donald Morrison | Compositions for treating skin disorders |
| AU658461B2 (en) * | 1991-12-03 | 1995-04-13 | Smithkline Beecham Plc | Skin care composition |
| US7316810B1 (en) | 1998-06-19 | 2008-01-08 | Galderma S.A. | Foaming composition for washing and treating hair and/or scalp based on an active principle |
| CN100464741C (zh) * | 2002-12-12 | 2009-03-04 | 盖尔德马研究及发展公司 | 含有酚衍生物和类维生素a的含水醇脱色素凝胶 |
| RU2355393C2 (ru) * | 2002-12-12 | 2009-05-20 | Галдерма Ресерч Энд Девелопмент, Снс | Депигментирующий водно-спиртовой гель |
| EP1865968A4 (en) * | 2005-03-24 | 2010-05-12 | Anacor Pharmaceuticals Inc | TOPICAL FORMULATIONS OF BORIC ACID ANTIBODIES AND ITS APPLICATION METHODS |
| EP2401037A2 (en) | 2009-02-25 | 2012-01-04 | Unilever PLC | Shear gels and compositions comprising shear gels |
| EP1641476B1 (fr) * | 2003-07-07 | 2017-03-29 | Jean-Noël THOREL | Combinaison d'antioxydants dans une composition a usage dermatologique et/ou cosmetique |
| WO2024114654A1 (zh) * | 2022-12-02 | 2024-06-06 | 南京毓浠医药技术有限公司 | 一种含维a酸组合物及其制备方法和用途 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889847A (en) * | 1986-11-03 | 1989-12-26 | Ortho Pharmaceutical Corporation | Prevention of glucocorticoid-induced skin atrophy |
| MY105521A (en) * | 1989-04-17 | 1994-10-31 | Healthpoint Ltd | Moisturizing vehicle for topical application of vitamin a acid. |
| NZ244862A (en) * | 1991-10-23 | 1995-07-26 | Block Drug Co | Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent |
| AU670777B2 (en) * | 1992-04-16 | 1996-08-01 | Ortho Pharmaceutical Corporation | Aqueous gel vehicles for retinoids |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL257621A (enrdf_load_stackoverflow) * | 1959-11-23 | |||
| US3729568A (en) * | 1969-09-23 | 1973-04-24 | Johnson & Johnson | Acne treatment |
-
1976
- 1976-01-12 IN IN74/CAL/1976A patent/IN142640B/en unknown
- 1976-01-13 NZ NZ179755A patent/NZ179755A/xx unknown
- 1976-01-13 FR FR7600725A patent/FR2354092A1/fr active Granted
- 1976-01-14 CA CA243,496A patent/CA1063515A/en not_active Expired
- 1976-01-15 NL NL7600388A patent/NL7600388A/xx not_active Application Discontinuation
- 1976-01-16 SE SE7600436A patent/SE429924B/xx not_active IP Right Cessation
- 1976-01-16 NO NO760149A patent/NO760149L/no unknown
- 1976-01-16 DK DK018276A patent/DK157781C/da active
- 1976-01-16 AT AT0027276A patent/AT363191B/de not_active IP Right Cessation
- 1976-01-16 DE DE19762601489 patent/DE2601489A1/de active Granted
- 1976-01-16 PH PH17983A patent/PH18090A/en unknown
- 1976-01-16 AU AU10351/76A patent/AU499339B2/en not_active Expired
- 1976-01-16 ZA ZA760251A patent/ZA76251B/xx unknown
- 1976-01-16 BE BE163589A patent/BE837662A/xx not_active IP Right Cessation
- 1976-01-16 FI FI760089A patent/FI56931B/fi not_active Application Discontinuation
- 1976-01-16 GB GB181076A patent/GB1476717A/en not_active Expired
- 1976-01-16 LU LU74195A patent/LU74195A1/xx unknown
- 1976-01-17 PT PT64709A patent/PT64709B/pt unknown
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4214000A (en) | 1978-10-30 | 1980-07-22 | Johnson & Johnson | Zinc salt of all-trans-retinoic acid for the treatment of acne |
| EP0090378A1 (en) * | 1982-03-26 | 1983-10-05 | Eisai Co., Ltd. | Isoprenylcarboxylic acid-containing composition for external use |
| GB2128087A (en) * | 1982-10-07 | 1984-04-26 | Ciba Geigy Ag | Topically administrable anti-inflammatory pharmaceutical compositions |
| US4917886A (en) * | 1982-10-07 | 1990-04-17 | Ciba-Geigy Corporation | Novel topically administrable pharmaceutical compositions |
| AU658461B2 (en) * | 1991-12-03 | 1995-04-13 | Smithkline Beecham Plc | Skin care composition |
| GB2268402A (en) * | 1992-06-19 | 1994-01-12 | Ian Donald Morrison | Compositions for treating skin disorders |
| US8066975B2 (en) | 1998-06-19 | 2011-11-29 | Galderma S.A. | Foaming composition for washing and treating hair and/or scalp based on an active principle |
| US7700081B2 (en) | 1998-06-19 | 2010-04-20 | Galderma S.A. | Foaming compositions for hair care |
| US8066976B2 (en) | 1998-06-19 | 2011-11-29 | Galderma S.A. | Foaming compositions for hair care |
| US7316810B1 (en) | 1998-06-19 | 2008-01-08 | Galderma S.A. | Foaming composition for washing and treating hair and/or scalp based on an active principle |
| CN100464741C (zh) * | 2002-12-12 | 2009-03-04 | 盖尔德马研究及发展公司 | 含有酚衍生物和类维生素a的含水醇脱色素凝胶 |
| RU2355393C2 (ru) * | 2002-12-12 | 2009-05-20 | Галдерма Ресерч Энд Девелопмент, Снс | Депигментирующий водно-спиртовой гель |
| EP1641476B1 (fr) * | 2003-07-07 | 2017-03-29 | Jean-Noël THOREL | Combinaison d'antioxydants dans une composition a usage dermatologique et/ou cosmetique |
| EP1865968A4 (en) * | 2005-03-24 | 2010-05-12 | Anacor Pharmaceuticals Inc | TOPICAL FORMULATIONS OF BORIC ACID ANTIBODIES AND ITS APPLICATION METHODS |
| EP2401037A2 (en) | 2009-02-25 | 2012-01-04 | Unilever PLC | Shear gels and compositions comprising shear gels |
| WO2024114654A1 (zh) * | 2022-12-02 | 2024-06-06 | 南京毓浠医药技术有限公司 | 一种含维a酸组合物及其制备方法和用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2601489A1 (de) | 1976-07-22 |
| FR2354092B1 (enrdf_load_stackoverflow) | 1981-09-18 |
| AU499339B2 (en) | 1979-04-12 |
| NZ179755A (en) | 1978-06-20 |
| LU74195A1 (enrdf_load_stackoverflow) | 1976-05-18 |
| ZA76251B (en) | 1977-08-31 |
| CA1063515A (en) | 1979-10-02 |
| ATA27276A (de) | 1980-12-15 |
| PT64709A (fr) | 1976-02-01 |
| FI56931B (fi) | 1980-01-31 |
| DK157781C (da) | 1990-08-13 |
| FR2354092A1 (fr) | 1978-01-06 |
| SE429924B (sv) | 1983-10-10 |
| AT363191B (de) | 1981-07-10 |
| FI760089A7 (enrdf_load_stackoverflow) | 1976-07-18 |
| PH18090A (en) | 1985-03-20 |
| DE2601489C2 (enrdf_load_stackoverflow) | 1990-02-01 |
| BE837662A (fr) | 1976-07-16 |
| NO760149L (enrdf_load_stackoverflow) | 1976-07-20 |
| DK157781B (da) | 1990-02-19 |
| NL7600388A (nl) | 1976-07-20 |
| SE7600436L (sv) | 1976-07-18 |
| PT64709B (fr) | 1978-01-04 |
| AU1035176A (en) | 1977-07-21 |
| IN142640B (enrdf_load_stackoverflow) | 1977-08-06 |
| DK18276A (da) | 1976-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SP | Amendment (slips) printed | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19960115 |