GB1476717A - Tretinoin in a gel vehicle for acne treatment - Google Patents

Tretinoin in a gel vehicle for acne treatment

Info

Publication number
GB1476717A
GB1476717A GB181076A GB181076A GB1476717A GB 1476717 A GB1476717 A GB 1476717A GB 181076 A GB181076 A GB 181076A GB 181076 A GB181076 A GB 181076A GB 1476717 A GB1476717 A GB 1476717A
Authority
GB
United Kingdom
Prior art keywords
tretinoin
organic solvent
johnson
jan
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB181076A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson KK
Johnson and Johnson
Original Assignee
Johnson and Johnson KK
Johnson and Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson KK, Johnson and Johnson filed Critical Johnson and Johnson KK
Publication of GB1476717A publication Critical patent/GB1476717A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

1476717 Tretinoin in a gel vehicle for acne treatment JOHNSON & JOHNSON 16 Jan 1976 [17 Jan 1975] 01810/76 Heading A5B A gel formulation for topical application for the treatment of dermatological disorders such as acne comprises at least 0.001% by weight of tretinoin (vitamin A acid), and a vehicle system consisting essentially of an organic solvent which is ethanol, isopropanol, propylene glycol or a mixture thereof, an effective amount of a pharmaceutically acceptable antioxidant soluble in the organic solvent e.g. a butylated hydroxyanisole, a butylated hydroxytoluene, α-tocopherol, ascorbic acid or propyl gallate, and an effective amount of a pharmaceutically acceptable gelling agent solvated in the organic solvent e.g. hydroxyethylcellulose, hydroxypropyl cellulose or an acidic carboxy polymer which is neutralised with an organic amine such as #-alanine and diisopropanolamine. The formulations may also contain at least one dye, perfume oil, sunscreen, antimicrobial or topical corticosteroid e.g. hydrocortisone.
GB181076A 1975-01-17 1976-01-16 Tretinoin in a gel vehicle for acne treatment Expired GB1476717A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54190675A 1975-01-17 1975-01-17

Publications (1)

Publication Number Publication Date
GB1476717A true GB1476717A (en) 1977-06-16

Family

ID=24161582

Family Applications (1)

Application Number Title Priority Date Filing Date
GB181076A Expired GB1476717A (en) 1975-01-17 1976-01-16 Tretinoin in a gel vehicle for acne treatment

Country Status (18)

Country Link
AT (1) AT363191B (en)
AU (1) AU499339B2 (en)
BE (1) BE837662A (en)
CA (1) CA1063515A (en)
DE (1) DE2601489A1 (en)
DK (1) DK157781C (en)
FI (1) FI56931B (en)
FR (1) FR2354092A1 (en)
GB (1) GB1476717A (en)
IN (1) IN142640B (en)
LU (1) LU74195A1 (en)
NL (1) NL7600388A (en)
NO (1) NO760149L (en)
NZ (1) NZ179755A (en)
PH (1) PH18090A (en)
PT (1) PT64709B (en)
SE (1) SE429924B (en)
ZA (1) ZA76251B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214000A (en) 1978-10-30 1980-07-22 Johnson & Johnson Zinc salt of all-trans-retinoic acid for the treatment of acne
EP0090378A1 (en) * 1982-03-26 1983-10-05 Eisai Co., Ltd. Isoprenylcarboxylic acid-containing composition for external use
GB2128087A (en) * 1982-10-07 1984-04-26 Ciba Geigy Ag Topically administrable anti-inflammatory pharmaceutical compositions
GB2268402A (en) * 1992-06-19 1994-01-12 Ian Donald Morrison Compositions for treating skin disorders
AU658461B2 (en) * 1991-12-03 1995-04-13 Smithkline Beecham Plc Skin care composition
EP1641476A2 (en) * 2003-07-07 2006-04-05 Jean-Noel Thorel Use of an antioxidant in a dermatological and/or cosmetic composition
EP1865968A2 (en) * 2005-03-24 2007-12-19 Anacor Pharmaceuticals, Inc. Topical formulations of borinic acid antibodies and their methods of use
US7316810B1 (en) 1998-06-19 2008-01-08 Galderma S.A. Foaming composition for washing and treating hair and/or scalp based on an active principle
CN100464741C (en) * 2002-12-12 2009-03-04 盖尔德马研究及发展公司 Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid
EP2401037A2 (en) 2009-02-25 2012-01-04 Unilever PLC Shear gels and compositions comprising shear gels
WO2024114654A1 (en) * 2022-12-02 2024-06-06 南京毓浠医药技术有限公司 Composition containing tretinoin, preparation method therefor, and use thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
MY105521A (en) * 1989-04-17 1994-10-31 Healthpoint Ltd Moisturizing vehicle for topical application of vitamin a acid.
NZ244862A (en) * 1991-10-23 1995-07-26 Block Drug Co Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent
AU670777B2 (en) * 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
EP1572176A2 (en) * 2002-12-12 2005-09-14 Galderma Research & Development, S.N.C. Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL257621A (en) * 1959-11-23
US3729568A (en) * 1969-09-23 1973-04-24 Johnson & Johnson Acne treatment

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214000A (en) 1978-10-30 1980-07-22 Johnson & Johnson Zinc salt of all-trans-retinoic acid for the treatment of acne
EP0090378A1 (en) * 1982-03-26 1983-10-05 Eisai Co., Ltd. Isoprenylcarboxylic acid-containing composition for external use
GB2128087A (en) * 1982-10-07 1984-04-26 Ciba Geigy Ag Topically administrable anti-inflammatory pharmaceutical compositions
US4917886A (en) * 1982-10-07 1990-04-17 Ciba-Geigy Corporation Novel topically administrable pharmaceutical compositions
AU658461B2 (en) * 1991-12-03 1995-04-13 Smithkline Beecham Plc Skin care composition
GB2268402A (en) * 1992-06-19 1994-01-12 Ian Donald Morrison Compositions for treating skin disorders
US7316810B1 (en) 1998-06-19 2008-01-08 Galderma S.A. Foaming composition for washing and treating hair and/or scalp based on an active principle
US7700081B2 (en) 1998-06-19 2010-04-20 Galderma S.A. Foaming compositions for hair care
US8066975B2 (en) 1998-06-19 2011-11-29 Galderma S.A. Foaming composition for washing and treating hair and/or scalp based on an active principle
US8066976B2 (en) 1998-06-19 2011-11-29 Galderma S.A. Foaming compositions for hair care
CN100464741C (en) * 2002-12-12 2009-03-04 盖尔德马研究及发展公司 Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid
EP1641476A2 (en) * 2003-07-07 2006-04-05 Jean-Noel Thorel Use of an antioxidant in a dermatological and/or cosmetic composition
EP1641476B1 (en) * 2003-07-07 2017-03-29 Jean-Noël THOREL Combination of antioxidants in a dermatological and/or cosmetic composition
EP1865968A2 (en) * 2005-03-24 2007-12-19 Anacor Pharmaceuticals, Inc. Topical formulations of borinic acid antibodies and their methods of use
EP1865968A4 (en) * 2005-03-24 2010-05-12 Anacor Pharmaceuticals Inc Topical formulations of borinic acid antibodies and their methods of use
EP2401037A2 (en) 2009-02-25 2012-01-04 Unilever PLC Shear gels and compositions comprising shear gels
WO2024114654A1 (en) * 2022-12-02 2024-06-06 南京毓浠医药技术有限公司 Composition containing tretinoin, preparation method therefor, and use thereof

Also Published As

Publication number Publication date
FR2354092A1 (en) 1978-01-06
DK157781B (en) 1990-02-19
DK18276A (en) 1976-07-18
NL7600388A (en) 1976-07-20
FR2354092B1 (en) 1981-09-18
CA1063515A (en) 1979-10-02
DE2601489C2 (en) 1990-02-01
PT64709B (en) 1978-01-04
IN142640B (en) 1977-08-06
NZ179755A (en) 1978-06-20
FI760089A (en) 1976-07-18
AT363191B (en) 1981-07-10
LU74195A1 (en) 1976-05-18
PH18090A (en) 1985-03-20
ZA76251B (en) 1977-08-31
DE2601489A1 (en) 1976-07-22
FI56931B (en) 1980-01-31
AU499339B2 (en) 1979-04-12
BE837662A (en) 1976-07-16
SE429924B (en) 1983-10-10
SE7600436L (en) 1976-07-18
PT64709A (en) 1976-02-01
NO760149L (en) 1976-07-20
ATA27276A (en) 1980-12-15
DK157781C (en) 1990-08-13
AU1035176A (en) 1977-07-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
429A Application made for amendment of specification (sect. 29/1949)
429H Application (made) for amendment of specification now open to opposition (sect. 29/1949)
429D Case decided by the comptroller ** specification amended (sect. 29/1949)
SP Amendment (slips) printed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960115