GB1397893A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB1397893A
GB1397893A GB2649273A GB2649273A GB1397893A GB 1397893 A GB1397893 A GB 1397893A GB 2649273 A GB2649273 A GB 2649273A GB 2649273 A GB2649273 A GB 2649273A GB 1397893 A GB1397893 A GB 1397893A
Authority
GB
United Kingdom
Prior art keywords
june
pharmaceutical compositions
edetate
carboxypoylmethylene
waterwhite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2649273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1397893A publication Critical patent/GB1397893A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1397893 Pharmaceutical compositions MERCK & CO INC 4 June 1973 [9 June 1972 30 June 1972] 26492/73 Heading A5B Anti-inflammatory compositions for topical administration comprise 2'-(4-pyridyl)-6, 16α- dimethyl-11#-17α, 21-trihydroxypregna-4, 6-diene [3, 2-c] pyrazol-20-one or a pharmaceutically acceptable salt thereof and a clear waterwhite gel including water, at least one organic solvent such as ethyl alcohol, isopropyl alcohol, propylene glycol, glycerine, 2-octyl dodecanol and methyl pyrrolidine, and at least one thickening agent such as hydroxyethyl cellulose, hydroxypropyl cellulose and a carboxypoylmethylene having a molecular weight of 940. The composition may also contain a stabilizing agent such as disodium edetate, sodium citrate, dipotassium edetate and citric acid.
GB2649273A 1972-06-09 1973-06-04 Pharmaceutical compositions Expired GB1397893A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26118672A 1972-06-09 1972-06-09
US26774372A 1972-06-30 1972-06-30

Publications (1)

Publication Number Publication Date
GB1397893A true GB1397893A (en) 1975-06-18

Family

ID=26948452

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2649273A Expired GB1397893A (en) 1972-06-09 1973-06-04 Pharmaceutical compositions

Country Status (8)

Country Link
CA (1) CA1014856A (en)
DE (1) DE2329130A1 (en)
FR (1) FR2187340B1 (en)
GB (1) GB1397893A (en)
IE (1) IE37718B1 (en)
IL (1) IL42365A (en)
NL (1) NL7307072A (en)
PH (1) PH10968A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112852B1 (en) * 1982-06-24 1988-06-08 SMITH, Robert Alan Pharmaceutical gel composition
WO1990014833A1 (en) 1989-06-07 1990-12-13 Bazzano Gail S Slow release vehicles for minimizing skin irritancy of topical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135267A (en) * 1971-02-25
BE786884A (en) * 1971-07-30 1973-01-29 Merck & Co Inc STERANIC PYRAZOLE AND PROCESS

Also Published As

Publication number Publication date
IE37718L (en) 1973-12-09
FR2187340A1 (en) 1974-01-18
CA1014856A (en) 1977-08-02
DE2329130A1 (en) 1973-12-20
PH10968A (en) 1977-10-18
IL42365A (en) 1977-04-29
NL7307072A (en) 1973-12-11
IL42365A0 (en) 1973-07-30
IE37718B1 (en) 1977-09-28
FR2187340B1 (en) 1976-10-22
AU5625573A (en) 1974-12-05

Similar Documents

Publication Publication Date Title
ES2263183T3 (en) A COMPOSITION OF GEL BASED ON NITROIMIDAZOL.
HUP9902121A2 (en) Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
ES8500738A1 (en) Topical anti-inflammatory compositions.
FI810604L (en) FOERFARANDE FOER FRAMSTAELLNING AV INDANDERIVAT
IL102814A0 (en) Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them
IE35811B1 (en) Diazepine derivatives and a process for their manufacture
HUT49614A (en) Process for producing cefalosporin derivatives and pharmaceutical compositions comprising these compounds
US3230143A (en) Antihypertensive injection methods using acid addition salts of alkyl esters of alpha-methyl-3, 4-dihy-droxyphenylalanine
NO950134L (en) Formulations for orally administered pharmaceutical agents
ES427079A1 (en) Phenothiazine derivatives, compositions thereof and methods of preparation thereof
GB1397893A (en) Pharmaceutical compositions
IE44339L (en) Piperazine derivatives.
EP0302836B1 (en) Pharmaceutical compositions for topical use containing miocamycin
ES471993A1 (en) Derivatives of pentacyclic alcaloids, method for their preparation, application in the synthesis of products of the eburnamonine group and pharmaceutical compositions.
GB1470355A (en) Pharmaceutical compositions
JPH07157431A (en) Stable prostaglandin e preparation
US3526698A (en) Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol
GB1453234A (en) Liquid vehicle for pharmaceutical compositions
GB1270049A (en) New pharmaceutical product
GB1446237A (en) Pharmaceutical preparations containing pyrazolones
EP0056681A3 (en) Levonantradol and n-methyllevonantradol formulations
GB1219700A (en) Pharmaceutical compositions comprising lincomycin derivatives
ATE300293T1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING POORLY SOLUBLE MEDICINAL SUBSTANCES
GB1440832A (en) Pharmaceutical preparation comprising antibiotics
GB1173985A (en) Indole Derivatives

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee