GB1464630A - Human proinsulin c-peptide derivatives - Google Patents
Human proinsulin c-peptide derivativesInfo
- Publication number
- GB1464630A GB1464630A GB3108174A GB3108174A GB1464630A GB 1464630 A GB1464630 A GB 1464630A GB 3108174 A GB3108174 A GB 3108174A GB 3108174 A GB3108174 A GB 3108174A GB 1464630 A GB1464630 A GB 1464630A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gly
- leu
- glu
- gln
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical class OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 10
- 108010076181 Proinsulin Proteins 0.000 abstract 6
- 150000001413 amino acids Chemical group 0.000 abstract 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 5
- CQGSYZCULZMEDE-UHFFFAOYSA-N Leu-Gln-Pro Natural products CC(C)CC(N)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(O)=O CQGSYZCULZMEDE-UHFFFAOYSA-N 0.000 abstract 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 4
- MCRMUCXATQAAMN-HNNXBMFYSA-N (2s)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC=1C=CC=CC=1)C1=CC=C(O)C=C1 MCRMUCXATQAAMN-HNNXBMFYSA-N 0.000 abstract 3
- YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 abstract 3
- 108010024078 alanyl-glycyl-serine Proteins 0.000 abstract 3
- 108010038088 glutamyl-glycyl-seryl-leucyl-glutamine Proteins 0.000 abstract 3
- 108010073093 leucyl-glycyl-glycyl-glycine Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108010029020 prolylglycine Proteins 0.000 abstract 3
- 108010008685 alanyl-glutamyl-aspartic acid Proteins 0.000 abstract 2
- 108010057083 glutamyl-aspartyl-leucine Proteins 0.000 abstract 2
- 108010049041 glutamylalanine Proteins 0.000 abstract 2
- 108010090894 prolylleucine Proteins 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 108010075254 C-Peptide Proteins 0.000 abstract 1
- UGVQELHRNUDMAA-BYPYZUCNSA-N Gly-Ala-Gly Chemical compound [NH3+]CC(=O)N[C@@H](C)C(=O)NCC([O-])=O UGVQELHRNUDMAA-BYPYZUCNSA-N 0.000 abstract 1
- BUEFQXUHTUZXHR-LURJTMIESA-N Gly-Gly-Pro zwitterion Chemical compound NCC(=O)NCC(=O)N1CCC[C@H]1C(O)=O BUEFQXUHTUZXHR-LURJTMIESA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- BEGDZYNDCNEGJZ-XVKPBYJWSA-N Val-Gly-Gln Chemical compound CC(C)[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CCC(N)=O BEGDZYNDCNEGJZ-XVKPBYJWSA-N 0.000 abstract 1
- NLTSCOZQKALPGZ-UHFFFAOYSA-N acetic acid;dihydrate Chemical compound O.O.CC(O)=O NLTSCOZQKALPGZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 activated tyrosine ester Chemical class 0.000 abstract 1
- 108010013835 arginine glutamate Proteins 0.000 abstract 1
- 108010068380 arginylarginine Proteins 0.000 abstract 1
- VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 1
- 108010051307 glycyl-glycyl-proline Proteins 0.000 abstract 1
- 108010010147 glycylglutamine Proteins 0.000 abstract 1
- 108010050848 glycylleucine Proteins 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP48079469A JPS5210872B2 (en:Method) | 1973-07-14 | 1973-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1464630A true GB1464630A (en) | 1977-02-16 |
Family
ID=13690737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3108174A Expired GB1464630A (en) | 1973-07-14 | 1974-07-12 | Human proinsulin c-peptide derivatives |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3953418A (en:Method) |
| JP (1) | JPS5210872B2 (en:Method) |
| CA (1) | CA1038860A (en:Method) |
| FR (1) | FR2236845B1 (en:Method) |
| GB (1) | GB1464630A (en:Method) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327072A (en) | 1978-10-02 | 1982-04-27 | Shionogi & Co., Ltd. | Tyrosylated proinsulin C-peptide derivatives |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA824218B (en) * | 1981-06-29 | 1983-04-27 | Cetus Corp | Plasmid for producing human insulin |
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| JPS6189253U (en:Method) * | 1984-11-19 | 1986-06-10 | ||
| CA2194548A1 (en) * | 1994-07-08 | 1996-01-25 | William F. Hickey | Proinsulin peptide compounds for detecting and treating type i diabetes |
| US6509165B1 (en) * | 1994-07-08 | 2003-01-21 | Trustees Of Dartmouth College | Detection methods for type I diabetes |
| AU3117697A (en) * | 1996-05-06 | 1997-11-26 | Uab Research Foundation, The | Radiolabeled fusion toxins for cancer therapy |
| SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| GB9716790D0 (en) | 1997-08-07 | 1997-10-15 | Creative Peptides Sweden Ab | Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof |
| US6890896B1 (en) * | 1999-11-18 | 2005-05-10 | Ceremedix, Inc. | Compositions and methods for counteracting effects of reactive oxygen species and free radicals |
| AU2003244053A1 (en) * | 2003-06-03 | 2005-01-21 | Shanghai Centre Of Research And Development Of New Drugs | A fusion protein suitable to be expressed high effectively and the production method thereof |
| CN111690064A (zh) * | 2020-06-24 | 2020-09-22 | 合肥天麦生物科技发展有限公司 | 一种胰岛素原前体蛋白的检测方法及其ppi单克隆抗体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3715434A (en) * | 1970-04-07 | 1973-02-06 | Research Corp | Iodopeptide anticoagulants |
-
1973
- 1973-07-14 JP JP48079469A patent/JPS5210872B2/ja not_active Expired
-
1974
- 1974-07-12 GB GB3108174A patent/GB1464630A/en not_active Expired
- 1974-07-15 FR FR7424552A patent/FR2236845B1/fr not_active Expired
- 1974-07-15 US US05/488,855 patent/US3953418A/en not_active Expired - Lifetime
- 1974-07-15 CA CA204,777A patent/CA1038860A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327072A (en) | 1978-10-02 | 1982-04-27 | Shionogi & Co., Ltd. | Tyrosylated proinsulin C-peptide derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2433647A1 (de) | 1975-01-30 |
| US3953418A (en) | 1976-04-27 |
| FR2236845B1 (en:Method) | 1976-12-24 |
| JPS5210872B2 (en:Method) | 1977-03-26 |
| CA1038860A (en) | 1978-09-19 |
| FR2236845A1 (en:Method) | 1975-02-07 |
| JPS5069068A (en:Method) | 1975-06-09 |
| DE2433647B2 (de) | 1976-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |