GB1456964A - 1-aryl-uracils their production and their medicinal use - Google Patents

1-aryl-uracils their production and their medicinal use

Info

Publication number
GB1456964A
GB1456964A GB1241175A GB1241175A GB1456964A GB 1456964 A GB1456964 A GB 1456964A GB 1241175 A GB1241175 A GB 1241175A GB 1241175 A GB1241175 A GB 1241175A GB 1456964 A GB1456964 A GB 1456964A
Authority
GB
United Kingdom
Prior art keywords
compounds
alkyl
represent hydrogen
different
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1241175A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1456964A publication Critical patent/GB1456964A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

1456964 1-Aryl-uracils BAYER AG 25 March 1975 [26 March 1974 3 May 1974 30 Nov 1974] 12411/75 Heading C2C The invention comprises novel compounds (I) wherein Ar represents optionally substituted aryl, R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> can be identical or different and represent hydrogen, alkyl, halogen, alkoxy, nitro, acylamino, nitrile, alkoxycarbonyl, trifluoromethyl or the radicals wherein R<SP>8</SP> and B<SP>9</SP> can be identical or different and represent hydrogen, alkyl or alkenyl, or wherein R<SP>8</SP> and R<SP>9</SP> together with the nitrogen atom can form a heterocyclic ring which optionally contains further hetero-atoms and, R<SP>5</SP>, R<SP>6</SP> and R<SP>7</SP> can be identical or different and represent hydrogen, alkyl, alkenyl or cyano and X represents oxygen, sulphur, SO or SO 2 or a salt thereof. They are made by reacting compounds (II) (obtained from the corresponding nitro compounds) with (R<SP>10</SP> is alkyl) and cyclizing the compounds (IV) obtained, or by reacting (II) with (R<SP>11</SP> and R<SP>12</SP> are alkyl) and heating the compounds (VII) obtained to give the nitriles (VIII) which are hydrolysed to give (I) via compounds (IX). Pharmaceutical preparations active against coccidiosis contain (I) as active ingredient. Administration may be orally, parenterally or topically.
GB1241175A 1974-03-26 1975-03-25 1-aryl-uracils their production and their medicinal use Expired GB1456964A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2414612A DE2414612A1 (en) 1974-03-26 1974-03-26 1-ARYLURACILE, THE METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
GB1456964A true GB1456964A (en) 1976-12-01

Family

ID=5911235

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1241175A Expired GB1456964A (en) 1974-03-26 1975-03-25 1-aryl-uracils their production and their medicinal use

Country Status (20)

Country Link
JP (2) JPS50129720A (en)
AT (1) AT336039B (en)
BE (1) BE827119A (en)
CA (1) CA1036604A (en)
CS (1) CS188945B2 (en)
DD (1) DD119232A5 (en)
DE (1) DE2414612A1 (en)
DK (1) DK139138C (en)
ES (1) ES436034A1 (en)
FI (1) FI750870A (en)
FR (1) FR2265388B1 (en)
GB (1) GB1456964A (en)
HU (1) HU170782B (en)
IE (1) IE41222B1 (en)
IL (1) IL46890A0 (en)
LU (1) LU72124A1 (en)
NL (1) NL7503630A (en)
PH (1) PH12431A (en)
SE (1) SE7503470L (en)
ZA (1) ZA751883B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7915257B2 (en) 2000-08-17 2011-03-29 Bayer Animal Health Gmbh Use of triazinetrione sulfones for combating coccidiosis
WO2020111263A1 (en) * 2018-11-30 2020-06-04 Otsuka Pharmaceutical Co., Ltd. Heterocyclic compounds for the treatment of epilepsy

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018157843A1 (en) * 2017-03-02 2018-09-07 中国科学院上海药物研究所 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7915257B2 (en) 2000-08-17 2011-03-29 Bayer Animal Health Gmbh Use of triazinetrione sulfones for combating coccidiosis
WO2020111263A1 (en) * 2018-11-30 2020-06-04 Otsuka Pharmaceutical Co., Ltd. Heterocyclic compounds for the treatment of epilepsy

Also Published As

Publication number Publication date
DD119232A5 (en) 1976-04-12
ATA223675A (en) 1976-08-15
ES436034A1 (en) 1977-01-01
JPS50140467A (en) 1975-11-11
DK128175A (en) 1975-09-27
CS188945B2 (en) 1979-03-30
BE827119A (en) 1975-09-25
FR2265388B1 (en) 1978-08-04
SE7503470L (en) 1975-09-29
DK139138C (en) 1979-05-28
HU170782B (en) 1977-09-28
IE41222B1 (en) 1979-11-21
AU7952075A (en) 1976-09-30
CA1036604A (en) 1978-08-15
DE2414612A1 (en) 1975-10-16
AT336039B (en) 1977-04-12
ZA751883B (en) 1976-02-25
FR2265388A1 (en) 1975-10-24
DK139138B (en) 1978-12-27
PH12431A (en) 1979-02-22
IL46890A0 (en) 1975-05-22
FI750870A (en) 1975-09-27
JPS50129720A (en) 1975-10-14
NL7503630A (en) 1975-09-30
LU72124A1 (en) 1976-02-04
IE41222L (en) 1975-09-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee