ES436034A1 - 1-aryl-uracils their production and their medicinal use - Google Patents

1-aryl-uracils their production and their medicinal use

Info

Publication number
ES436034A1
ES436034A1 ES436034A ES436034A ES436034A1 ES 436034 A1 ES436034 A1 ES 436034A1 ES 436034 A ES436034 A ES 436034A ES 436034 A ES436034 A ES 436034A ES 436034 A1 ES436034 A1 ES 436034A1
Authority
ES
Spain
Prior art keywords
formula
indicated above
see formula
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436034A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES436034A1 publication Critical patent/ES436034A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

Procedure for obtaining 1-aryluracils of formula **(See formula)** where Ar is aryl, optionally substituted, R1, R2, R3 and R4 may be the same or different and signify hydrogen, alkyl, halogen, nitro, acylamino, nitrile, alkoxycarbonyl, trifluoromethyl or the residues **(See formula)** where R8 and R9 may be the same or different and signify hydrogen, alkyl, alkenyl, or where R8 and R9 together with the nitrogen atom may form an heterocyclic ring, optionally containing further heteroatoms, and R5, R6 and R7 may be the same or different and signify hydrogen, alkyl or alkenyl, and X signifies oxygen, sulfur, SO or SO2, characterized in that a) compounds of formula **(See formula)** Where Ar, X, R1, R2, R3 and R4 have the meaning indicated above, they are reacted with an acyl isocyanate of the formula **(See formula)** where R5 and R6 have the meaning indicated above and R10 means alkyl, and then the compounds thus obtained, of the formula **(See formula)** where Ar, X, R1, R2, R3, R4, R5, R6 and R10 have the meanings indicated above, they are treated with alkali metal alkoxides and the alkaline salt of the corresponding uraric derivative thus obtained, of formula **(See formula)** where Ar, X, R1, R2, R3, R4, R5 and R6 have the meanings indicated above and Me ⊕ means an alkali metal cation by treatment with acids is transformed into the free uracil or, optionally with alkylating or alkenylating agents, is transformed into N-alkyl or N-alkenyl compounds, or b) compounds of formula **(See formula)** Where Ar, X, R1, R2, R3 and R4 have the meanings indicated above, they are reacted with a compound of the formula **(See formula)** where R5 has the meaning indicated above and R11 and R12 mean alkyl, and the enamine derivatives thus obtained, of the formula **(See formula)** where Ar, X, R1, R2, R3, R4 and R12 have the meanings indicated above, upon heating they are transformed into uracil derivatives of the formula **(See formula)** where Ar, X, R1, R2, R3, R4 and R5 have the meanings indicated above, and if appropriate they are isolated, as well as by hydrolysis at higher temperatures they are transformed into the compounds of formula **(See formula)** where Ar, R1, R2, R3 and R4 have the meaning indicated above, if necessary they are isolated and, by subsequent hydrolysis and decarboxylation, they are transformed into compounds of formula **(See formula)** and these, optionally with alkylating or alkenylating agents, are converted into N-alkyl or N-alkenyl compounds. (Machine-translation by Google Translate, not legally binding)
ES436034A 1974-03-26 1975-03-25 1-aryl-uracils their production and their medicinal use Expired ES436034A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2414612A DE2414612A1 (en) 1974-03-26 1974-03-26 1-ARYLURACILE, THE METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
ES436034A1 true ES436034A1 (en) 1977-01-01

Family

ID=5911235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436034A Expired ES436034A1 (en) 1974-03-26 1975-03-25 1-aryl-uracils their production and their medicinal use

Country Status (20)

Country Link
JP (2) JPS50140467A (en)
AT (1) AT336039B (en)
BE (1) BE827119A (en)
CA (1) CA1036604A (en)
CS (1) CS188945B2 (en)
DD (1) DD119232A5 (en)
DE (1) DE2414612A1 (en)
DK (1) DK139138C (en)
ES (1) ES436034A1 (en)
FI (1) FI750870A (en)
FR (1) FR2265388B1 (en)
GB (1) GB1456964A (en)
HU (1) HU170782B (en)
IE (1) IE41222B1 (en)
IL (1) IL46890A0 (en)
LU (1) LU72124A1 (en)
NL (1) NL7503630A (en)
PH (1) PH12431A (en)
SE (1) SE7503470L (en)
ZA (1) ZA751883B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10040174A1 (en) 2000-08-17 2002-02-28 Bayer Ag Treatment of coccidiosis comprises administration of haloalkylsulfonyl substituted phenoxyphenyl-triazinetrione derivatives
WO2018157843A1 (en) * 2017-03-02 2018-09-07 中国科学院上海药物研究所 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof
EA202191473A1 (en) * 2018-11-30 2021-08-27 Оцука Фармасьютикал Ко., Лтд. HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY

Also Published As

Publication number Publication date
AT336039B (en) 1977-04-12
JPS50129720A (en) 1975-10-14
GB1456964A (en) 1976-12-01
IL46890A0 (en) 1975-05-22
NL7503630A (en) 1975-09-30
SE7503470L (en) 1975-09-29
JPS50140467A (en) 1975-11-11
FI750870A (en) 1975-09-27
ZA751883B (en) 1976-02-25
CS188945B2 (en) 1979-03-30
DD119232A5 (en) 1976-04-12
IE41222B1 (en) 1979-11-21
ATA223675A (en) 1976-08-15
DK139138B (en) 1978-12-27
PH12431A (en) 1979-02-22
DE2414612A1 (en) 1975-10-16
LU72124A1 (en) 1976-02-04
DK139138C (en) 1979-05-28
DK128175A (en) 1975-09-27
FR2265388B1 (en) 1978-08-04
AU7952075A (en) 1976-09-30
IE41222L (en) 1975-09-26
BE827119A (en) 1975-09-25
CA1036604A (en) 1978-08-15
FR2265388A1 (en) 1975-10-24
HU170782B (en) 1977-09-28

Similar Documents

Publication Publication Date Title
ES411804A1 (en) (2-imidazolin-2-y(amino) substituted quinolines, -quinoxalines and -quinazolines as antihypertensive agents
CA1272482C (en) Quinolinecarboxylic acid derivatives
ES330164A1 (en) A procedure for preparing a triamide of a phosphorus acid. (Machine-translation by Google Translate, not legally binding)
ES436034A1 (en) 1-aryl-uracils their production and their medicinal use
ES417638A1 (en) 2,4,5-trisubstituted oxazoles
ES400820A1 (en) Imidazo-pyridine derivatives
GB866843A (en) Sulphonamidopyrimidines
ES390163A1 (en) Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES419019A1 (en) Indolo-2,3-c quinolinone derivatives
ES418113A1 (en) Piperazino-pyrimidines process for their preparation and use
ES425576A1 (en) Pyrazoles and process for their preparation
ES296381A1 (en) Procedure for the obtaining of new polybasic compounds (Machine-translation by Google Translate, not legally binding)
ES475120A1 (en) Imidazopyridazines and their use as therapeutic agents
SE7812371L (en) PROCEDURE FOR PREPARING PHENOXIAL CANOLAMINE DERIVATIVES
ES440532A1 (en) Process for the production of 3-hydroxy-1,2,4-triazole derivatives
ES451293A1 (en) A procedure for the preparation of tienotiacin derivatives. (Machine-translation by Google Translate, not legally binding)
ES431552A1 (en) Triazine-diones
ES419450A1 (en) Exchange amination process
ES406098A1 (en) Substituted 2,6-dinitroanilines and herbicidal compositions containing them
ES412248A1 (en) O2,2-anhydro-1- beta-d-arabino-furanosyl-cytosine derivatives methods for their preparation and related procedures
ES291672A1 (en) Procedure for obtaining benzanilide derivatives (Machine-translation by Google Translate, not legally binding)
ES440195A1 (en) Flavone derivatives
ES285855A1 (en) A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)
ES388696A1 (en) Cyano-and trifluoromethyl-substituted 6-nitroanilines
ES429319A1 (en) Pyridine derivatives