ES436034A1 - 1-aryl-uracils their production and their medicinal use - Google Patents
1-aryl-uracils their production and their medicinal useInfo
- Publication number
- ES436034A1 ES436034A1 ES436034A ES436034A ES436034A1 ES 436034 A1 ES436034 A1 ES 436034A1 ES 436034 A ES436034 A ES 436034A ES 436034 A ES436034 A ES 436034A ES 436034 A1 ES436034 A1 ES 436034A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- indicated above
- see formula
- alkyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Procedure for obtaining 1-aryluracils of formula **(See formula)** where Ar is aryl, optionally substituted, R1, R2, R3 and R4 may be the same or different and signify hydrogen, alkyl, halogen, nitro, acylamino, nitrile, alkoxycarbonyl, trifluoromethyl or the residues **(See formula)** where R8 and R9 may be the same or different and signify hydrogen, alkyl, alkenyl, or where R8 and R9 together with the nitrogen atom may form an heterocyclic ring, optionally containing further heteroatoms, and R5, R6 and R7 may be the same or different and signify hydrogen, alkyl or alkenyl, and X signifies oxygen, sulfur, SO or SO2, characterized in that a) compounds of formula **(See formula)** Where Ar, X, R1, R2, R3 and R4 have the meaning indicated above, they are reacted with an acyl isocyanate of the formula **(See formula)** where R5 and R6 have the meaning indicated above and R10 means alkyl, and then the compounds thus obtained, of the formula **(See formula)** where Ar, X, R1, R2, R3, R4, R5, R6 and R10 have the meanings indicated above, they are treated with alkali metal alkoxides and the alkaline salt of the corresponding uraric derivative thus obtained, of formula **(See formula)** where Ar, X, R1, R2, R3, R4, R5 and R6 have the meanings indicated above and Me ⊕ means an alkali metal cation by treatment with acids is transformed into the free uracil or, optionally with alkylating or alkenylating agents, is transformed into N-alkyl or N-alkenyl compounds, or b) compounds of formula **(See formula)** Where Ar, X, R1, R2, R3 and R4 have the meanings indicated above, they are reacted with a compound of the formula **(See formula)** where R5 has the meaning indicated above and R11 and R12 mean alkyl, and the enamine derivatives thus obtained, of the formula **(See formula)** where Ar, X, R1, R2, R3, R4 and R12 have the meanings indicated above, upon heating they are transformed into uracil derivatives of the formula **(See formula)** where Ar, X, R1, R2, R3, R4 and R5 have the meanings indicated above, and if appropriate they are isolated, as well as by hydrolysis at higher temperatures they are transformed into the compounds of formula **(See formula)** where Ar, R1, R2, R3 and R4 have the meaning indicated above, if necessary they are isolated and, by subsequent hydrolysis and decarboxylation, they are transformed into compounds of formula **(See formula)** and these, optionally with alkylating or alkenylating agents, are converted into N-alkyl or N-alkenyl compounds. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2414612A DE2414612A1 (en) | 1974-03-26 | 1974-03-26 | 1-ARYLURACILE, THE METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT |
Publications (1)
Publication Number | Publication Date |
---|---|
ES436034A1 true ES436034A1 (en) | 1977-01-01 |
Family
ID=5911235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES436034A Expired ES436034A1 (en) | 1974-03-26 | 1975-03-25 | 1-aryl-uracils their production and their medicinal use |
Country Status (20)
Country | Link |
---|---|
JP (2) | JPS50140467A (en) |
AT (1) | AT336039B (en) |
BE (1) | BE827119A (en) |
CA (1) | CA1036604A (en) |
CS (1) | CS188945B2 (en) |
DD (1) | DD119232A5 (en) |
DE (1) | DE2414612A1 (en) |
DK (1) | DK139138C (en) |
ES (1) | ES436034A1 (en) |
FI (1) | FI750870A (en) |
FR (1) | FR2265388B1 (en) |
GB (1) | GB1456964A (en) |
HU (1) | HU170782B (en) |
IE (1) | IE41222B1 (en) |
IL (1) | IL46890A0 (en) |
LU (1) | LU72124A1 (en) |
NL (1) | NL7503630A (en) |
PH (1) | PH12431A (en) |
SE (1) | SE7503470L (en) |
ZA (1) | ZA751883B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10040174A1 (en) | 2000-08-17 | 2002-02-28 | Bayer Ag | Treatment of coccidiosis comprises administration of haloalkylsulfonyl substituted phenoxyphenyl-triazinetrione derivatives |
WO2018157843A1 (en) * | 2017-03-02 | 2018-09-07 | 中国科学院上海药物研究所 | 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof |
EA202191473A1 (en) * | 2018-11-30 | 2021-08-27 | Оцука Фармасьютикал Ко., Лтд. | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY |
-
1974
- 1974-03-26 DE DE2414612A patent/DE2414612A1/en active Pending
-
1975
- 1975-03-19 PH PH16935A patent/PH12431A/en unknown
- 1975-03-20 CA CA222,621A patent/CA1036604A/en not_active Expired
- 1975-03-21 IL IL46890A patent/IL46890A0/en unknown
- 1975-03-24 FI FI750870A patent/FI750870A/fi not_active Application Discontinuation
- 1975-03-24 JP JP50034576A patent/JPS50140467A/ja active Pending
- 1975-03-24 AT AT223675A patent/AT336039B/en not_active IP Right Cessation
- 1975-03-24 LU LU72124A patent/LU72124A1/xx unknown
- 1975-03-24 JP JP50034577A patent/JPS50129720A/ja active Pending
- 1975-03-24 DD DD184981A patent/DD119232A5/xx unknown
- 1975-03-25 GB GB1241175A patent/GB1456964A/en not_active Expired
- 1975-03-25 IE IE660/75A patent/IE41222B1/en unknown
- 1975-03-25 ZA ZA00751883A patent/ZA751883B/en unknown
- 1975-03-25 BE BE154706A patent/BE827119A/en unknown
- 1975-03-25 SE SE7503470A patent/SE7503470L/xx unknown
- 1975-03-25 DK DK128175A patent/DK139138C/en active
- 1975-03-25 ES ES436034A patent/ES436034A1/en not_active Expired
- 1975-03-26 HU HU75BA00003235A patent/HU170782B/en unknown
- 1975-03-26 FR FR7509510A patent/FR2265388B1/fr not_active Expired
- 1975-03-26 NL NL7503630A patent/NL7503630A/en not_active Application Discontinuation
- 1975-03-26 CS CS752053A patent/CS188945B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AT336039B (en) | 1977-04-12 |
JPS50129720A (en) | 1975-10-14 |
GB1456964A (en) | 1976-12-01 |
IL46890A0 (en) | 1975-05-22 |
NL7503630A (en) | 1975-09-30 |
SE7503470L (en) | 1975-09-29 |
JPS50140467A (en) | 1975-11-11 |
FI750870A (en) | 1975-09-27 |
ZA751883B (en) | 1976-02-25 |
CS188945B2 (en) | 1979-03-30 |
DD119232A5 (en) | 1976-04-12 |
IE41222B1 (en) | 1979-11-21 |
ATA223675A (en) | 1976-08-15 |
DK139138B (en) | 1978-12-27 |
PH12431A (en) | 1979-02-22 |
DE2414612A1 (en) | 1975-10-16 |
LU72124A1 (en) | 1976-02-04 |
DK139138C (en) | 1979-05-28 |
DK128175A (en) | 1975-09-27 |
FR2265388B1 (en) | 1978-08-04 |
AU7952075A (en) | 1976-09-30 |
IE41222L (en) | 1975-09-26 |
BE827119A (en) | 1975-09-25 |
CA1036604A (en) | 1978-08-15 |
FR2265388A1 (en) | 1975-10-24 |
HU170782B (en) | 1977-09-28 |
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