GB1447923A - Indazole derivatives processes for their preparation and pharma ceutical compositions containing them - Google Patents
Indazole derivatives processes for their preparation and pharma ceutical compositions containing themInfo
- Publication number
- GB1447923A GB1447923A GB1923974A GB1923974A GB1447923A GB 1447923 A GB1447923 A GB 1447923A GB 1923974 A GB1923974 A GB 1923974A GB 1923974 A GB1923974 A GB 1923974A GB 1447923 A GB1447923 A GB 1447923A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- hydrogen atom
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- -1 phenyl radicals Chemical class 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 abstract 3
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexyloxide Natural products O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 3
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 150000007857 hydrazones Chemical class 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- NYOWYNSNCXRVNQ-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-indazole Chemical class C1=CCC2CNNC2=C1 NYOWYNSNCXRVNQ-UHFFFAOYSA-N 0.000 abstract 1
- ZWSFFBUZTDBGKQ-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1h-indazol-3-amine Chemical class C1CCCC2=C1NN=C2N ZWSFFBUZTDBGKQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- JHIVVAPYMSGYDF-PTQBSOBMSA-N cyclohexanone Chemical class O=[13C]1CCCCC1 JHIVVAPYMSGYDF-PTQBSOBMSA-N 0.000 abstract 1
- 125000001240 enamine group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1923974A GB1447923A (en) | 1974-05-02 | 1974-05-02 | Indazole derivatives processes for their preparation and pharma ceutical compositions containing them |
| US05/570,937 US3978044A (en) | 1974-05-02 | 1975-04-22 | Indazole derivatives, processes for making the same and pharmaceutical compositions |
| DE2519077A DE2519077C3 (de) | 1974-05-02 | 1975-04-29 | 3-Amino-4,5,6,7-tetrahydroindazole, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen |
| FR7513320A FR2269342B1 (cg-RX-API-DMAC7.html) | 1974-05-02 | 1975-04-29 | |
| BE155995A BE828633A (fr) | 1974-05-02 | 1975-04-30 | Nouveaux indazoles, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1923974A GB1447923A (en) | 1974-05-02 | 1974-05-02 | Indazole derivatives processes for their preparation and pharma ceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1447923A true GB1447923A (en) | 1976-09-02 |
Family
ID=10126036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1923974A Expired GB1447923A (en) | 1974-05-02 | 1974-05-02 | Indazole derivatives processes for their preparation and pharma ceutical compositions containing them |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3978044A (cg-RX-API-DMAC7.html) |
| BE (1) | BE828633A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2519077C3 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2269342B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1447923A (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772232B2 (en) * | 2004-04-15 | 2010-08-10 | Bristol-Myers Squibb Company | Quinazolinyl compounds as inhibitors of potassium channel function |
| EP1874301A4 (en) * | 2005-04-13 | 2009-05-06 | Merck & Co Inc | Niacin receptor agonists, compositions containing such compounds and treatment methods |
| US20080200458A1 (en) * | 2007-01-18 | 2008-08-21 | Joseph Barbosa | Methods and compositions for the treatment of body composition disorders |
| WO2008089307A2 (en) * | 2007-01-18 | 2008-07-24 | Lexicon Pharmaceuticals, Inc. | Delta 5 desaturase inhibitors for the treatment of pain, inflammation and cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133081A (en) * | 1964-05-12 | J-aminoindazole derivatives | ||
| DE1948793A1 (de) * | 1969-09-26 | 1971-04-01 | Rhein Chemie Rheinau Gmbh | Verfahren zur Herstellung von 4,5,6,7-Tetrahydroindazolen |
-
1974
- 1974-05-02 GB GB1923974A patent/GB1447923A/en not_active Expired
-
1975
- 1975-04-22 US US05/570,937 patent/US3978044A/en not_active Expired - Lifetime
- 1975-04-29 FR FR7513320A patent/FR2269342B1/fr not_active Expired
- 1975-04-29 DE DE2519077A patent/DE2519077C3/de not_active Expired
- 1975-04-30 BE BE155995A patent/BE828633A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2519077A1 (de) | 1975-11-06 |
| FR2269342A1 (cg-RX-API-DMAC7.html) | 1975-11-28 |
| BE828633A (fr) | 1975-10-30 |
| FR2269342B1 (cg-RX-API-DMAC7.html) | 1980-01-11 |
| DE2519077B2 (de) | 1979-07-26 |
| US3978044A (en) | 1976-08-31 |
| DE2519077C3 (de) | 1980-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |