GB1446791A - 1,3-diketo-1,2,3,4-tetrahydroisoquinolines - Google Patents
1,3-diketo-1,2,3,4-tetrahydroisoquinolinesInfo
- Publication number
- GB1446791A GB1446791A GB3908374A GB3908374A GB1446791A GB 1446791 A GB1446791 A GB 1446791A GB 3908374 A GB3908374 A GB 3908374A GB 3908374 A GB3908374 A GB 3908374A GB 1446791 A GB1446791 A GB 1446791A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- group
- defined above
- dimethoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QGNQEODJYRGEJX-UHFFFAOYSA-N 4h-isoquinoline-1,3-dione Chemical class C1=CC=C2C(=O)NC(=O)CC2=C1 QGNQEODJYRGEJX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- ANOUKFYBOAKOIR-UHFFFAOYSA-N 3,4-dimethoxyphenylethylamine Chemical compound COC1=CC=C(CCN)C=C1OC ANOUKFYBOAKOIR-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- CBHOOMGKXCMKIR-UHFFFAOYSA-N azane;methanol Chemical compound N.OC CBHOOMGKXCMKIR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- ZLPVHRHKOAFZMH-UHFFFAOYSA-N n'-[2-(3,4-dimethoxyphenyl)ethyl]propane-1,3-diamine Chemical compound COC1=CC=C(CCNCCCN)C=C1OC ZLPVHRHKOAFZMH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2345422A DE2345422C2 (de) | 1973-09-08 | 1973-09-08 | Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung |
| DE19732345423 DE2345423A1 (de) | 1973-09-08 | 1973-09-08 | Neue substituierte phenylaethylaminderivate, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1446791A true GB1446791A (en) | 1976-08-18 |
Family
ID=25765764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3908374A Expired GB1446791A (en) | 1973-09-08 | 1974-09-06 | 1,3-diketo-1,2,3,4-tetrahydroisoquinolines |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US3948898A (enExample) |
| JP (1) | JPS596868B2 (enExample) |
| AT (1) | AT330777B (enExample) |
| BG (2) | BG22390A3 (enExample) |
| CA (1) | CA1025869A (enExample) |
| CH (2) | CH605778A5 (enExample) |
| CS (1) | CS185660B2 (enExample) |
| DD (1) | DD115122A5 (enExample) |
| DK (1) | DK137124C (enExample) |
| ES (3) | ES429473A1 (enExample) |
| FI (1) | FI52219C (enExample) |
| FR (1) | FR2242979B1 (enExample) |
| GB (1) | GB1446791A (enExample) |
| HK (1) | HK4180A (enExample) |
| HU (1) | HU167869B (enExample) |
| IE (1) | IE40742B1 (enExample) |
| IL (1) | IL45609A (enExample) |
| MY (1) | MY8100330A (enExample) |
| NL (1) | NL176363C (enExample) |
| NO (1) | NO140978C (enExample) |
| PH (1) | PH12918A (enExample) |
| PL (1) | PL91712B1 (enExample) |
| RO (1) | RO63655A (enExample) |
| SE (1) | SE424863B (enExample) |
| SU (2) | SU538664A3 (enExample) |
| YU (1) | YU39928B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2639718A1 (de) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | Neue phenylaethylamine |
| DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
| US8338405B2 (en) | 2006-02-28 | 2012-12-25 | Dart Neuroscience Llc | Therapeutic piperazines |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
| JPS6312877U (enExample) * | 1986-03-05 | 1988-01-27 | ||
| US4876256A (en) * | 1988-04-29 | 1989-10-24 | Merck & Co., Inc. | Alkylpiperazinylpyridines as hypoglycemic agents |
| US5169948A (en) * | 1991-05-22 | 1992-12-08 | American Home Products Corporation | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors |
| SE9303274D0 (sv) * | 1993-10-07 | 1993-10-07 | Astra Ab | Novel phenylethyl and phenylproplamines |
| KR100607838B1 (ko) | 1997-10-27 | 2006-08-04 | 뉴로서치 에이/에스 | 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물 |
| US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| EP1844033B1 (de) * | 2005-01-28 | 2011-07-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur herstellung von isochroman und derivaten davon |
| WO2023288039A1 (en) * | 2021-07-16 | 2023-01-19 | Denali Therapeutics Inc. | Compounds, compositions and methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1185934A (en) * | 1967-06-28 | 1970-03-25 | Pfizer & Co C | Derivatives of 1,3(2H,4H)-Dioxoisoquinoline and preparation thereof |
| SE368009B (enExample) * | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| GB1424348A (en) * | 1972-11-30 | 1976-02-11 | Wyeth John & Brother Ltd | Isoquinoline derivatives |
-
1974
- 1974-08-08 AT AT651474A patent/AT330777B/de active
- 1974-08-21 FI FI742465A patent/FI52219C/fi active
- 1974-08-23 ES ES429473A patent/ES429473A1/es not_active Expired
- 1974-09-04 IE IE1838/74A patent/IE40742B1/xx unknown
- 1974-09-04 BG BG027624A patent/BG22390A3/xx unknown
- 1974-09-04 BG BG028726A patent/BG26195A4/xx unknown
- 1974-09-04 US US05/503,072 patent/US3948898A/en not_active Expired - Lifetime
- 1974-09-05 YU YU2391/74A patent/YU39928B/xx unknown
- 1974-09-06 CS CS7400006150A patent/CS185660B2/cs unknown
- 1974-09-06 DD DD180966A patent/DD115122A5/xx unknown
- 1974-09-06 DK DK472774A patent/DK137124C/da not_active IP Right Cessation
- 1974-09-06 FR FR7430387A patent/FR2242979B1/fr not_active Expired
- 1974-09-06 IL IL45609A patent/IL45609A/en unknown
- 1974-09-06 CH CH1218974A patent/CH605778A5/xx not_active IP Right Cessation
- 1974-09-06 PH PH16248A patent/PH12918A/en unknown
- 1974-09-06 CA CA208,607A patent/CA1025869A/en not_active Expired
- 1974-09-06 SE SE7411312A patent/SE424863B/xx not_active IP Right Cessation
- 1974-09-06 NL NLAANVRAGE7411843,A patent/NL176363C/xx not_active IP Right Cessation
- 1974-09-06 JP JP49102862A patent/JPS596868B2/ja not_active Expired
- 1974-09-06 CH CH1601477A patent/CH605779A5/xx not_active IP Right Cessation
- 1974-09-06 NO NO743220A patent/NO140978C/no unknown
- 1974-09-06 GB GB3908374A patent/GB1446791A/en not_active Expired
- 1974-09-06 HU HUTO980A patent/HU167869B/hu unknown
- 1974-09-06 RO RO7400079932A patent/RO63655A/ro unknown
- 1974-09-07 PL PL1974173958A patent/PL91712B1/pl unknown
-
1975
- 1975-01-20 ES ES433959A patent/ES433959A1/es not_active Expired
- 1975-01-20 ES ES433958A patent/ES433958A1/es not_active Expired
- 1975-06-20 SU SU2145942A patent/SU538664A3/ru active
- 1975-06-20 SU SU2145935A patent/SU545256A3/ru active
-
1980
- 1980-01-31 HK HK41/80A patent/HK4180A/xx unknown
-
1981
- 1981-12-30 MY MY330/81A patent/MY8100330A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2639718A1 (de) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | Neue phenylaethylamine |
| DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
| US8338405B2 (en) | 2006-02-28 | 2012-12-25 | Dart Neuroscience Llc | Therapeutic piperazines |
| AU2007221021B2 (en) * | 2006-02-28 | 2013-01-17 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as PDE4 inhibitors |
| US8501745B2 (en) | 2006-02-28 | 2013-08-06 | Dart Neuroscience (Cayman) Ltd. | Piperazine PDE4 inhibitors and uses thereof |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| US9624200B2 (en) | 2006-02-28 | 2017-04-18 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1164503A (en) | Azaspiroalkanediones, process for preparing the same and Pharmaceutical Compositions comprising the same | |
| HUT41761A (en) | Process for producing tricyclic aromatic compounds | |
| IE41539L (en) | Chroman derivatives. | |
| GB1138529A (en) | Novel imidazole derivatives and a process for the manufacture thereof | |
| GB1488692A (en) | Pyrazolo(3,4,6)quinolines | |
| GB1507717A (en) | Benz(de)isoquinoline derivatives | |
| ES433959A1 (es) | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. | |
| GB1514776A (en) | Compositions containing oxamic acid derivatives | |
| GB1069797A (en) | ª-aminoketone derivatives | |
| GB1507709A (en) | Benz(de)isoquinoline derivatives | |
| GB1154976A (en) | N-Phenyl Indoline Derivatives | |
| GB1436936A (en) | Erfoline derivatives | |
| GB1469006A (en) | 2-phenylhydrazinothiazolines or-thiazines and a process for the preparation thereof | |
| GB1457038A (en) | Amino derivatives of 1,4-benzodioxan | |
| GB1474133A (en) | Benzindole derivatives | |
| GB1305458A (enExample) | ||
| GB1437896A (en) | Substituted thiazole-2-carboxylic amides and process for the preparation thereof | |
| GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
| GB1461667A (en) | Amphetamine derivatives | |
| GB1448781A (en) | N- omega-amino- alkylaniline compounds | |
| GB1449078A (en) | Phenoxyethylamine derivatives | |
| GB1430926A (en) | 2-amino-3,4-dihydropyridines their production and their medicinal use | |
| IE39658L (en) | N-substituted glycinate pharmaceuticals | |
| GB1469197A (en) | Preparation of 1-aminoalkyl triazolobenzodiazepines | |
| GB1446833A (en) | Hydroxamic acid derivatives of substituted a-aminooxycarboxylic acids and a process for the preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |