GB1428883A - 1,3-benzoxazine and phenyl-alkylamine derivatives - Google Patents

1,3-benzoxazine and phenyl-alkylamine derivatives

Info

Publication number
GB1428883A
GB1428883A GB2301374A GB2301374A GB1428883A GB 1428883 A GB1428883 A GB 1428883A GB 2301374 A GB2301374 A GB 2301374A GB 2301374 A GB2301374 A GB 2301374A GB 1428883 A GB1428883 A GB 1428883A
Authority
GB
United Kingdom
Prior art keywords
general formula
pharmaceutically acceptable
phenylalkylaminomethyl
alkoxyphenol
formaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2301374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1428883A publication Critical patent/GB1428883A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Abstract

1428883 3 - Phenylalkyl - 3,4 - dihydro- 8 - alkoxy - 2H - 1,3 - benzoxazines TAKEDA YAKUHIN KOGYO KK 23 May 1974 [28 May 1973] 23013/74 Heading C2C Novel 3 - phenylalkyl - 3,4 - dihydro - 8- alkoxy - 2H - 1,3 - benzoxazines of the general formula wherein R<SP>1</SP> is a C 1 -C 4 alkyl group, R<SP>2</SP> is a hydrogen atom or a C 1 -C 4 alkyl or C 2 -C 4 alkenyl group, R<SP>3</SP> is a hydrogen atom, a C 1 -C 4 alkyl group, 1-4 C 1 -C 4 alkoxy groups or 1-4 halogen atoms and Y is a C 1 -C 4 alkylene group, and pharmaceutically acceptable acid addition salts thereof are prepared (a) byreacting a 2-phenylalkylaminomethyl-6-alkoxyphenol of the general formula with formaldehyde; (b) by reacting formaldehyde with a phenylalkylamine and a 2-alkoxyphenol of the respective general formulµ or (c) by reacting a 2-phenylalkylaminomethyl- 6-alkoxyphenol of the second general formula above with formaldehyde and a phenylalkylamine of the third general formula above; followed optionally by salification of the product. Novel 2 - phenylalkylaminomethyl - 6- alkoxyphenols of the second general formula above may be isolated as intermediates in process (b) above and optionally converted to pharmaceutically acceptable acid addition salts thereof. Pharamaceutical compositions having antidepressant activity comprise, as active ingredient, a compound of the first or second general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a non-toxic, pharmaceutically acceptable carrier or diluent therefor.
GB2301374A 1973-05-28 1974-05-23 1,3-benzoxazine and phenyl-alkylamine derivatives Expired GB1428883A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP48059495A JPS5012093A (en) 1973-05-28 1973-05-28

Publications (1)

Publication Number Publication Date
GB1428883A true GB1428883A (en) 1976-03-17

Family

ID=13114911

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2301374A Expired GB1428883A (en) 1973-05-28 1974-05-23 1,3-benzoxazine and phenyl-alkylamine derivatives

Country Status (5)

Country Link
JP (1) JPS5012093A (en)
DE (1) DE2425446A1 (en)
FR (1) FR2235930B1 (en)
GB (1) GB1428883A (en)
NL (1) NL7406778A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5473799A (en) * 1977-11-16 1979-06-13 Kanebo Ltd Preparation of 1,3-oxazino (5,6-c) rifamycin derivative
JPS5484600A (en) * 1977-12-15 1979-07-05 Kanebo Ltd Preparation of 1,3-oxazino 5,6-c rifamycin derivative
JPS5776597A (en) * 1980-10-30 1982-05-13 Kiyouritsu Kurieiteibu Asoshie Electric musical instrument
CN101646661A (en) * 2006-11-29 2010-02-10 汉高公司 The preparation method of benzoxazines

Also Published As

Publication number Publication date
JPS5012093A (en) 1975-02-07
FR2235930B1 (en) 1978-08-11
DE2425446A1 (en) 1974-12-19
FR2235930A1 (en) 1975-01-31
NL7406778A (en) 1974-12-02

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee