GB1428883A - 1,3-benzoxazine and phenyl-alkylamine derivatives - Google Patents
1,3-benzoxazine and phenyl-alkylamine derivativesInfo
- Publication number
- GB1428883A GB1428883A GB2301374A GB2301374A GB1428883A GB 1428883 A GB1428883 A GB 1428883A GB 2301374 A GB2301374 A GB 2301374A GB 2301374 A GB2301374 A GB 2301374A GB 1428883 A GB1428883 A GB 1428883A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- pharmaceutically acceptable
- phenylalkylaminomethyl
- alkoxyphenol
- formaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1428883 3 - Phenylalkyl - 3,4 - dihydro- 8 - alkoxy - 2H - 1,3 - benzoxazines TAKEDA YAKUHIN KOGYO KK 23 May 1974 [28 May 1973] 23013/74 Heading C2C Novel 3 - phenylalkyl - 3,4 - dihydro - 8- alkoxy - 2H - 1,3 - benzoxazines of the general formula wherein R<SP>1</SP> is a C 1 -C 4 alkyl group, R<SP>2</SP> is a hydrogen atom or a C 1 -C 4 alkyl or C 2 -C 4 alkenyl group, R<SP>3</SP> is a hydrogen atom, a C 1 -C 4 alkyl group, 1-4 C 1 -C 4 alkoxy groups or 1-4 halogen atoms and Y is a C 1 -C 4 alkylene group, and pharmaceutically acceptable acid addition salts thereof are prepared (a) byreacting a 2-phenylalkylaminomethyl-6-alkoxyphenol of the general formula with formaldehyde; (b) by reacting formaldehyde with a phenylalkylamine and a 2-alkoxyphenol of the respective general formulµ or (c) by reacting a 2-phenylalkylaminomethyl- 6-alkoxyphenol of the second general formula above with formaldehyde and a phenylalkylamine of the third general formula above; followed optionally by salification of the product. Novel 2 - phenylalkylaminomethyl - 6- alkoxyphenols of the second general formula above may be isolated as intermediates in process (b) above and optionally converted to pharmaceutically acceptable acid addition salts thereof. Pharamaceutical compositions having antidepressant activity comprise, as active ingredient, a compound of the first or second general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a non-toxic, pharmaceutically acceptable carrier or diluent therefor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP48059495A JPS5012093A (en) | 1973-05-28 | 1973-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1428883A true GB1428883A (en) | 1976-03-17 |
Family
ID=13114911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2301374A Expired GB1428883A (en) | 1973-05-28 | 1974-05-23 | 1,3-benzoxazine and phenyl-alkylamine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5012093A (en) |
| DE (1) | DE2425446A1 (en) |
| FR (1) | FR2235930B1 (en) |
| GB (1) | GB1428883A (en) |
| NL (1) | NL7406778A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5473799A (en) * | 1977-11-16 | 1979-06-13 | Kanebo Ltd | Preparation of 1,3-oxazino (5,6-c) rifamycin derivative |
| JPS5484600A (en) * | 1977-12-15 | 1979-07-05 | Kanebo Ltd | Preparation of 1,3-oxazino 5,6-c rifamycin derivative |
| JPS5776597A (en) * | 1980-10-30 | 1982-05-13 | Kiyouritsu Kurieiteibu Asoshie | Electric musical instrument |
| WO2008066855A1 (en) * | 2006-11-29 | 2008-06-05 | Henkel Corporation | Method of preparing benzoxazines |
-
1973
- 1973-05-28 JP JP48059495A patent/JPS5012093A/ja active Pending
-
1974
- 1974-05-20 NL NL7406778A patent/NL7406778A/xx unknown
- 1974-05-23 GB GB2301374A patent/GB1428883A/en not_active Expired
- 1974-05-25 DE DE19742425446 patent/DE2425446A1/en active Pending
- 1974-05-27 FR FR7418292A patent/FR2235930B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2235930B1 (en) | 1978-08-11 |
| JPS5012093A (en) | 1975-02-07 |
| DE2425446A1 (en) | 1974-12-19 |
| NL7406778A (en) | 1974-12-02 |
| FR2235930A1 (en) | 1975-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |