GB1445794A - Epimerisation process for lactone intermediates for prostaglandins - Google Patents
Epimerisation process for lactone intermediates for prostaglandinsInfo
- Publication number
- GB1445794A GB1445794A GB721574A GB721574A GB1445794A GB 1445794 A GB1445794 A GB 1445794A GB 721574 A GB721574 A GB 721574A GB 721574 A GB721574 A GB 721574A GB 1445794 A GB1445794 A GB 1445794A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- hydroxy
- alkyl
- radicals
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000002596 lactones Chemical class 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical class C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 phenyl radicals Chemical group 0.000 abstract 3
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002240 furans Chemical class 0.000 abstract 2
- USVVENVKYJZFMW-ONEGZZNKSA-N (e)-carboxyiminocarbamic acid Chemical compound OC(=O)\N=N\C(O)=O USVVENVKYJZFMW-ONEGZZNKSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 abstract 1
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB721574A GB1445794A (en) | 1974-02-18 | 1974-02-18 | Epimerisation process for lactone intermediates for prostaglandins |
| DE19752505303 DE2505303A1 (de) | 1974-02-18 | 1975-02-07 | Epimerisationsverfahren |
| FR7504830A FR2261280B1 (enrdf_load_stackoverflow) | 1974-02-18 | 1975-02-17 | |
| JP1965775A JPS5940832B2 (ja) | 1974-02-18 | 1975-02-17 | エピ化法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB721574A GB1445794A (en) | 1974-02-18 | 1974-02-18 | Epimerisation process for lactone intermediates for prostaglandins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1445794A true GB1445794A (en) | 1976-08-11 |
Family
ID=9828841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB721574A Expired GB1445794A (en) | 1974-02-18 | 1974-02-18 | Epimerisation process for lactone intermediates for prostaglandins |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5940832B2 (enrdf_load_stackoverflow) |
| DE (1) | DE2505303A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2261280B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1445794A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES449162A1 (es) * | 1975-06-23 | 1977-12-16 | Syntex Inc | Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico. |
-
1974
- 1974-02-18 GB GB721574A patent/GB1445794A/en not_active Expired
-
1975
- 1975-02-07 DE DE19752505303 patent/DE2505303A1/de not_active Ceased
- 1975-02-17 JP JP1965775A patent/JPS5940832B2/ja not_active Expired
- 1975-02-17 FR FR7504830A patent/FR2261280B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2261280B1 (enrdf_load_stackoverflow) | 1978-07-13 |
| JPS5940832B2 (ja) | 1984-10-03 |
| JPS50116466A (enrdf_load_stackoverflow) | 1975-09-11 |
| DE2505303A1 (de) | 1975-08-21 |
| FR2261280A1 (enrdf_load_stackoverflow) | 1975-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |