GB1445237A - 25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives - Google Patents

25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives

Info

Publication number
GB1445237A
GB1445237A GB4033475A GB4033475A GB1445237A GB 1445237 A GB1445237 A GB 1445237A GB 4033475 A GB4033475 A GB 4033475A GB 4033475 A GB4033475 A GB 4033475A GB 1445237 A GB1445237 A GB 1445237A
Authority
GB
United Kingdom
Prior art keywords
prepared
hydroxycholesterol
viii
compounds
hydroxycholestynes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4033475A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1445237A publication Critical patent/GB1445237A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB4033475A 1973-05-21 1974-05-20 25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives Expired GB1445237A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00362569A US3822254A (en) 1973-05-21 1973-05-21 Synthesis of 25-hydroxycholesterol

Publications (1)

Publication Number Publication Date
GB1445237A true GB1445237A (en) 1976-08-04

Family

ID=23426617

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4033475A Expired GB1445237A (en) 1973-05-21 1974-05-20 25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives
GB2247174A Expired GB1445236A (en) 1973-05-21 1974-05-20 Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2247174A Expired GB1445236A (en) 1973-05-21 1974-05-20 Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein

Country Status (9)

Country Link
US (1) US3822254A (enExample)
JP (1) JPS5614679B2 (enExample)
AT (1) AT343294B (enExample)
BE (1) BE815252A (enExample)
CH (1) CH617442A5 (enExample)
DE (1) DE2424498C3 (enExample)
FR (1) FR2236854B1 (enExample)
GB (2) GB1445237A (enExample)
NL (1) NL172956C (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5218700B2 (enExample) * 1973-02-16 1977-05-24
US3928397A (en) * 1973-03-02 1975-12-23 Eisai Co Ltd New 5-cholestene derivatives and preparation thereof
US3959320A (en) * 1974-09-23 1976-05-25 The Upjohn Company Process and compounds
US3976636A (en) * 1974-10-10 1976-08-24 The Upjohn Company Process and compounds
US3994934A (en) * 1975-01-27 1976-11-30 The Upjohn Company Process for preparing Δ22 -25-oxy substituted sterol derivatives
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4038272A (en) * 1975-10-20 1977-07-26 Hoffmann-La Roche Inc. Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof
US3994878A (en) * 1975-10-10 1976-11-30 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof
CH628907A5 (en) * 1975-10-10 1982-03-31 Hoffmann La Roche Process for the preparation of 24,25-dihydroxycholesterol derivatives
JPS5371056A (en) * 1976-12-08 1978-06-24 Chugai Pharmaceut Co Ltd Steroid derivs.
JPS53144563A (en) * 1977-05-19 1978-12-15 Chugai Pharmaceut Co Ltd Preparation of steroid derivatives
CA1138859A (en) * 1979-02-15 1983-01-04 Teijin Limited 25-hydroxy-24-oxocholestane derivatives and preparation thereof
CH644873A5 (de) * 1980-02-12 1984-08-31 Hoffmann La Roche Verfahren zur herstellung von cholesterinderivaten.
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
EA201990684A1 (ru) 2013-12-24 2020-12-30 Вирджиния Коммонвелт Юниверсити Способы применения оксигенированных холестеролсульфатов (ocs)
IL298681A (en) 2016-08-02 2023-01-01 Univ Virginia Commonwealth Preparations
CN111320663B (zh) * 2018-12-13 2023-01-24 上海医药工业研究院 一种24-胆烯烯酸乙酯中间体的制备方法
US20220204547A1 (en) 2019-05-09 2022-06-30 Fermenta Biotech Limited Novel method for synthesizing 25-oh cholesterol/calcifediol from phytosterol
EP3906247A4 (en) * 2019-07-09 2022-10-12 Fermenta Biotech Limited SYNTHESIS OF CHOLESTEROL AND VITAMIN D3 FROM PHYTOSTEROLS
CN111138512A (zh) * 2019-12-27 2020-05-12 郑州手性药物研究院有限公司 一种合成25-羟基胆固醇中间体的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1052283B (it) * 1968-07-01 1981-06-20 Wisconsin Alumni Res Found Processo per preparare composti del calciferolo e relativi composti
US3846455A (en) * 1972-05-22 1974-11-05 Eisai Co Ltd Process for the preparation of 25-hydroxy-cholesterol and esters thereof

Also Published As

Publication number Publication date
DE2424498A1 (de) 1974-12-12
JPS5614679B2 (enExample) 1981-04-06
DE2424498C3 (de) 1981-04-02
DE2424498B2 (de) 1980-06-04
ATA416374A (de) 1977-09-15
AT343294B (de) 1978-05-26
FR2236854B1 (enExample) 1977-10-21
US3822254A (en) 1974-07-02
GB1445236A (en) 1976-08-04
CH617442A5 (enExample) 1980-05-30
NL172956C (nl) 1983-11-16
JPS5018458A (enExample) 1975-02-26
BE815252A (fr) 1974-11-20
NL7406748A (enExample) 1974-11-25
FR2236854A1 (enExample) 1975-02-07
NL172956B (nl) 1983-06-16

Similar Documents

Publication Publication Date Title
GB1445236A (en) Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein
ES8707220A1 (es) Un metodo para sintetizar compuestos de ascorbato-2-polifosfato
ES8602837A1 (es) Un procedimiento para la preparacion de nuevas macrolidas antibioticas
GB1476215A (en) Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them
SE7408255L (enExample)
ES488225A1 (es) Procedimiento mejorado para la preparacion selectiva de iso-sorbida-5-nitrato
JPS5735597A (en) 25,26-epoxy-3beta,24-dihydroxycholest-5-ene or its hydroxyl- protected derivative and their preparation
GB1476993A (en) 27-non-cholesterol derivatives
ES469071A1 (es) Un procedimiento de inversion mejorado para la preparacion de cola para papel a partir de colofonia enriquecida
GB1362782A (en) Tetrazole derivatives
ES483377A1 (es) Procedimiento para preparar gamma-lactonas de esteroides
ES413272A1 (es) Un procedimiento para la preparacion de acido 5-fluor-2-me-til-1-(p-metilsulfinilbenciliden)-3-indenil-acetico.
GB1472131A (en) Alkyl derivatives of prostanoic acids and preparation thereof
ES8207251A1 (es) Procedimiento para la estampacion resistiva o de descarga demateriales textiles sinteticos
GB1388180A (en) Acetals
GB1497700A (en) Polysubstituted derivatives of 10/piperazinodibenzo(b,f)thiepin
IE36653B1 (en) 17-hydroxy-7-(lower alkoxy) carbonyl-3-oxo-17alpha-pregn-4-ene-21-carboxylic acidgamma-lactones and congeners
BE822342A (fr) Procede de preparation de dispersions aqueuses d'interpolymeresa faible viscosite
GB1333614A (en) Prostaglandins and their production and intermediate compounds produced therein
GB1473670A (en) Process for the manufacture of prostaglandin-f2a and analogues thereof
GB1414540A (en) Synthesis of a-and b-ring aromatic steroids
GB1381207A (en) Ketones
GB1359095A (en) Bis-stilbene compounds
GB1449914A (en) 2,2, 10beta, 17 alpha-tetramethyl steroids a process for their preparation and compositions containing them
GB1433095A (en) Cyclohexane and cyclohexene precursors of prostaglandin and their preparation

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee