GB1441706A - Crystalline monosodium n6, 2-o-dibutyryl-adenosine-3-5-cyclic monophosphate and production thereof - Google Patents
Crystalline monosodium n6, 2-o-dibutyryl-adenosine-3-5-cyclic monophosphate and production thereofInfo
- Publication number
- GB1441706A GB1441706A GB1449574A GB1449574A GB1441706A GB 1441706 A GB1441706 A GB 1441706A GB 1449574 A GB1449574 A GB 1449574A GB 1449574 A GB1449574 A GB 1449574A GB 1441706 A GB1441706 A GB 1441706A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nucleotide
- solvent
- dioxane
- acetone
- dibutyryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 9
- 239000002904 solvent Substances 0.000 abstract 7
- 239000002773 nucleotide Substances 0.000 abstract 5
- 125000003729 nucleotide group Chemical group 0.000 abstract 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 abstract 2
- 159000000000 sodium salts Chemical class 0.000 abstract 2
- YBPWNFMPWVRSOD-QDEZUTFSSA-N 5-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-5-hydroxynonane-4,6-dione Chemical compound C(CCC)(=O)C([C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(N)=NC=NC1=2)O)O)(O)C(CCC)=O YBPWNFMPWVRSOD-QDEZUTFSSA-N 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- -1 alkyl acetate Chemical compound 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3875673A JPS5210879B2 (cg-RX-API-DMAC10.html) | 1973-04-06 | 1973-04-06 | |
| JP3875773A JPS5210880B2 (cg-RX-API-DMAC10.html) | 1973-04-06 | 1973-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1441706A true GB1441706A (en) | 1976-07-07 |
Family
ID=26378047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1449574A Expired GB1441706A (en) | 1973-04-06 | 1974-04-02 | Crystalline monosodium n6, 2-o-dibutyryl-adenosine-3-5-cyclic monophosphate and production thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4015066A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1026327A (cg-RX-API-DMAC10.html) |
| CH (1) | CH606086A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2416709C2 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2224463B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1441706A (cg-RX-API-DMAC10.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040186282A1 (en) * | 2003-03-20 | 2004-09-23 | Chait Edward M. | Synthesis and method of purification of cyclic nucleotide derivatives |
| CN116606339A (zh) * | 2023-04-17 | 2023-08-18 | 南通宏慈药业有限公司 | 一种二丁酰环磷腺苷钠的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1336441A (en) * | 1969-10-10 | 1973-11-07 | Anvar | Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation |
| US3849397A (en) * | 1971-08-04 | 1974-11-19 | Int Chem & Nuclear Corp | 3',5'-cyclic monophosphate nucleosides |
| US3852267A (en) * | 1972-08-04 | 1974-12-03 | Icn Pharmaceuticals | Phosphoramidates of 3{40 ,5{40 -cyclic purine nucleotides |
| JPS5134443B2 (cg-RX-API-DMAC10.html) * | 1972-10-09 | 1976-09-27 |
-
1974
- 1974-04-02 GB GB1449574A patent/GB1441706A/en not_active Expired
- 1974-04-04 CA CA196,876A patent/CA1026327A/en not_active Expired
- 1974-04-05 FR FR7412112A patent/FR2224463B1/fr not_active Expired
- 1974-04-05 DE DE2416709A patent/DE2416709C2/de not_active Expired
- 1974-04-06 CH CH482074A patent/CH606086A5/xx not_active IP Right Cessation
- 1974-04-08 US US05/459,203 patent/US4015066A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH606086A5 (cg-RX-API-DMAC10.html) | 1978-10-13 |
| FR2224463B1 (cg-RX-API-DMAC10.html) | 1978-01-13 |
| FR2224463A1 (cg-RX-API-DMAC10.html) | 1974-10-31 |
| CA1026327A (en) | 1978-02-14 |
| DE2416709A1 (de) | 1974-10-24 |
| US4015066A (en) | 1977-03-29 |
| DE2416709C2 (de) | 1984-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |