GB1440063A - 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids - Google Patents

17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Info

Publication number
GB1440063A
GB1440063A GB3765572A GB3765572A GB1440063A GB 1440063 A GB1440063 A GB 1440063A GB 3765572 A GB3765572 A GB 3765572A GB 3765572 A GB3765572 A GB 3765572A GB 1440063 A GB1440063 A GB 1440063A
Authority
GB
United Kingdom
Prior art keywords
prepared
steroids
dihydroxy
ester
betamethasone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3765572A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB3765572A priority Critical patent/GB1440063A/en
Priority to LU68212A priority patent/LU68212A1/xx
Priority to JP48089358A priority patent/JPS5752359B2/ja
Priority to IL42942A priority patent/IL42942A/en
Priority to ZA735452A priority patent/ZA735452B/xx
Priority to IE1382/73A priority patent/IE38312B1/xx
Priority to BE134445A priority patent/BE803461A/xx
Priority to CA178,554A priority patent/CA1027109A/en
Priority to ES417738A priority patent/ES417738A1/es
Priority to FR7329443A priority patent/FR2205508B1/fr
Priority to DK440673AA priority patent/DK135998B/da
Priority to DE19732340591 priority patent/DE2340591A1/de
Priority to NL7311072A priority patent/NL7311072A/xx
Priority to ZA735453A priority patent/ZA735453B/xx
Priority to AU59143/73A priority patent/AU484233B2/en
Priority to US387487A priority patent/US3891631A/en
Priority to CH1159373A priority patent/CH590884A5/xx
Priority to SE7310985A priority patent/SE387951B/xx
Publication of GB1440063A publication Critical patent/GB1440063A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
GB3765572A 1972-08-11 1972-08-11 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids Expired GB1440063A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB3765572A GB1440063A (en) 1972-08-11 1972-08-11 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
LU68212A LU68212A1 (OSRAM) 1972-08-11 1973-08-10
JP48089358A JPS5752359B2 (OSRAM) 1972-08-11 1973-08-10
IL42942A IL42942A (en) 1972-08-11 1973-08-10 Process for the preparation of 17alpha-esters of 17alpha,21-dihydroxy-20-oxo steroids and some novel 17alpha-betamethasone esters
ZA735452A ZA735452B (en) 1972-08-11 1973-08-10 Improvemnts in or relating to steroid compounds
IE1382/73A IE38312B1 (en) 1972-08-11 1973-08-10 17-esters of 17,21-dihydroxy-20-oxo-steroids
BE134445A BE803461A (fr) 1972-08-11 1973-08-10 Production d'esters de steroides
CA178,554A CA1027109A (en) 1972-08-11 1973-08-10 PROCESS FOR THE PREPARATION OF 17.alpha.-ESTERS OF 17.alpha., 21-DIHYDROXY-20-OXO STEROIDS
ES417738A ES417738A1 (es) 1972-08-11 1973-08-10 Un procedimiento para la preparacion de esteres de 17 alfa-carboxilato o esteres neutros de carbonato o fosfato de 17 alfa 21-diluidroxi-20-oxo-esteroides.
FR7329443A FR2205508B1 (OSRAM) 1972-08-11 1973-08-10
DK440673AA DK135998B (da) 1972-08-11 1973-08-10 Fremgangsmåde til fremstilling af 17alfa-carboxylat- eller -(neutralt) phosphat- eller -carbonatestere af 17alfa,21-dihydroxy-20-oxo-steroider.
DE19732340591 DE2340591A1 (de) 1972-08-11 1973-08-10 Steroidverbindungen
NL7311072A NL7311072A (OSRAM) 1972-08-11 1973-08-10
ZA735453A ZA735453B (en) 1972-08-11 1973-08-10 Improvements in or relating to the preparation of 17 x-esters of 17d,21-dihydroxy-20-oxo-steroids
AU59143/73A AU484233B2 (en) 1973-08-10 Process for the preparation of 17-esters of 17, 21-dihydroxy-20-oxo steroids
US387487A US3891631A (en) 1972-08-11 1973-08-10 Process for preparing 17{60 -monoesters of 17{60 , 21-dihydroxy-20-oxo steroids
CH1159373A CH590884A5 (OSRAM) 1972-08-11 1973-08-10
SE7310985A SE387951B (sv) 1972-08-11 1973-08-10 Forfarande for framstellning av 17alfa-karboxylat eller neutrala 17alfa-fosfat-eller-karbonatestrar av 17alfa21-dihydroxi-20-oxo-steroider

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3765572A GB1440063A (en) 1972-08-11 1972-08-11 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Publications (1)

Publication Number Publication Date
GB1440063A true GB1440063A (en) 1976-06-23

Family

ID=10398029

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3765572A Expired GB1440063A (en) 1972-08-11 1972-08-11 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Country Status (16)

Country Link
US (1) US3891631A (OSRAM)
JP (1) JPS5752359B2 (OSRAM)
BE (1) BE803461A (OSRAM)
CA (1) CA1027109A (OSRAM)
CH (1) CH590884A5 (OSRAM)
DE (1) DE2340591A1 (OSRAM)
DK (1) DK135998B (OSRAM)
ES (1) ES417738A1 (OSRAM)
FR (1) FR2205508B1 (OSRAM)
GB (1) GB1440063A (OSRAM)
IE (1) IE38312B1 (OSRAM)
IL (1) IL42942A (OSRAM)
LU (1) LU68212A1 (OSRAM)
NL (1) NL7311072A (OSRAM)
SE (1) SE387951B (OSRAM)
ZA (2) ZA735452B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1516095A (en) * 1974-07-31 1978-06-28 Glaxo Lab Ltd 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series
GB1593978A (en) * 1976-12-31 1981-07-22 Lark Spa Anti-inflammatory steroids
US4086254A (en) * 1977-04-13 1978-04-25 The Upjohn Company Photocleavable steroids
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2759135A1 (de) * 1977-12-30 1979-07-19 Lark Spa Neue steroidverbindungen und deren herstellung und verwendung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
DE3133082A1 (de) 1981-08-18 1983-03-10 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue hydrocortison-derivate, ihre herstellung und verwendung
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives
DE3637806A1 (de) * 1986-11-06 1988-05-19 Hoechst Ag Verfahren zur herstellung von prednisolon-17-ethylcarbonat durch umlagerung von prednisolon-21-ethylcarbonat
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
ATE380194T1 (de) * 2000-08-05 2007-12-15 Glaxo Group Ltd 6.alpha.,9.alpha.-difluoro-17.alpha.-(2-
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
DE60229372D1 (de) * 2001-04-30 2008-11-27 Glaxo Group Ltd Antiphlogistische 7.beta.-carbothioate esterderivate von androstan mit einer 17.alpha.-zyklischen estergruppe
WO2003048181A1 (en) * 2001-12-01 2003-06-12 Glaxo Group Limited 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
CN103536599A (zh) 2008-05-28 2014-01-29 雷沃根生物医药有限公司 用于治疗疾病的NF-κB的非激素甾体调节剂
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255218A (en) * 1962-03-28 1966-06-07 Schering Corp 17(20)-enol-21-aldehydes of the pregnane series
US3780177A (en) * 1967-06-16 1973-12-18 Warner Lambert Co 17-butyrate,21-ester derivatives of 6alpha,9alpha-difluoroprednisolone,compositions and use
IT1034011B (it) * 1969-06-26 1979-09-10 Vister Vismara Terapeutici S P Processo per la prapratzione di 17 monoesteri di 17 a 21 diossisteroidi per idrolisi die corpispondenti 17 21 ortoesteri ciclici a ph control lato

Also Published As

Publication number Publication date
CH590884A5 (OSRAM) 1977-08-31
NL7311072A (OSRAM) 1974-02-13
CA1027109A (en) 1978-02-28
IE38312L (en) 1974-02-11
JPS4985062A (OSRAM) 1974-08-15
DK135998C (OSRAM) 1977-12-27
AU5914373A (en) 1975-02-13
IL42942A (en) 1977-05-31
BE803461A (fr) 1974-02-11
IE38312B1 (en) 1978-02-15
ES417738A1 (es) 1976-06-16
ZA735453B (en) 1974-10-30
LU68212A1 (OSRAM) 1973-10-16
IL42942A0 (en) 1973-11-28
DE2340591A1 (de) 1974-03-07
US3891631A (en) 1975-06-24
DK135998B (da) 1977-07-25
SE387951B (sv) 1976-09-20
JPS5752359B2 (OSRAM) 1982-11-06
FR2205508B1 (OSRAM) 1978-09-15
FR2205508A1 (OSRAM) 1974-05-31
ZA735452B (en) 1974-07-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee