GB1164646A - 2-Methylene-Steroids - Google Patents

2-Methylene-Steroids

Info

Publication number
GB1164646A
GB1164646A GB3827968A GB3827968A GB1164646A GB 1164646 A GB1164646 A GB 1164646A GB 3827968 A GB3827968 A GB 3827968A GB 3827968 A GB3827968 A GB 3827968A GB 1164646 A GB1164646 A GB 1164646A
Authority
GB
United Kingdom
Prior art keywords
methylene
steroid
steroids
estrane
oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3827968A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB1164646A publication Critical patent/GB1164646A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1,164,646. 2-Methylene steroids. STERLING DRUG Inc. 17 Oct., 1966 [22 Oct., 1965], No. 38279/68. Divided out of 1,164,644. Heading C2U. The invention comprises (1) a process for preparing a 2-methylene-3-oxo-steroid (the steroid moiety having from 17 to 23 carbon atoms exclusive of ester radicals and the 2-methylene group and being a member of the estrane, 18- nor-estrane, androstane, etiochlolane, cholane, pregnane or allopregnane series) wherein a 4<SP>1</SP>- hydroxyspiro-[steroid-2,5<SP>1</SP>-m-dioxan]-3-one is treated under mild alkaline conditions; and (2) steroids of the formula (wherein R is acetyl or a ketal thereof, 1,2-dihydroxyethyl or 1-hydroxyethyl; X is H 2 , H(α- or #-OH) or O; X<SP>11</SP> is H, alkyl or halogen; Y and Y<SP>1</SP> are H or CH 3 ; and Z is α-OH or α-H, or R and Z together are 17α,20; 20,21-bismethylenedioxy, there optionally being #<SP>4</SP> and/or #<SP>6</SP> double bonds present) and esters thereof derived from C 1-12 carboxylic acids. Protected, e.g. ketalized, keto groups may be hydrolysed to free keto groups.
GB3827968A 1965-10-22 1966-10-17 2-Methylene-Steroids Expired GB1164646A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50239465A 1965-10-22 1965-10-22

Publications (1)

Publication Number Publication Date
GB1164646A true GB1164646A (en) 1969-09-17

Family

ID=23997621

Family Applications (4)

Application Number Title Priority Date Filing Date
GB3827868A Expired GB1164645A (en) 1965-10-22 1966-10-17 2,2-Spiro-m-dioxano-Steriods
GB3828068A Expired GB1164647A (en) 1965-10-22 1966-10-17 2,2-Spiro-Pyrazolinyl-Steroids
GB4638366A Expired GB1164644A (en) 1965-10-22 1966-10-17 2,2-Ethylene-Steroids
GB3827968A Expired GB1164646A (en) 1965-10-22 1966-10-17 2-Methylene-Steroids

Family Applications Before (3)

Application Number Title Priority Date Filing Date
GB3827868A Expired GB1164645A (en) 1965-10-22 1966-10-17 2,2-Spiro-m-dioxano-Steriods
GB3828068A Expired GB1164647A (en) 1965-10-22 1966-10-17 2,2-Spiro-Pyrazolinyl-Steroids
GB4638366A Expired GB1164644A (en) 1965-10-22 1966-10-17 2,2-Ethylene-Steroids

Country Status (1)

Country Link
GB (4) GB1164645A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6209176B1 (en) * 1997-11-03 2001-04-03 National Molding Corporation Zipper pull cord fastener

Also Published As

Publication number Publication date
GB1164645A (en) 1969-09-17
GB1164644A (en) 1969-09-17
GB1164647A (en) 1969-09-17

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees