GB1436593A - N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp - Google Patents

N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

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Publication number
GB1436593A
GB1436593A GB1243073A GB1243073A GB1436593A GB 1436593 A GB1436593 A GB 1436593A GB 1243073 A GB1243073 A GB 1243073A GB 1243073 A GB1243073 A GB 1243073A GB 1436593 A GB1436593 A GB 1436593A
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GB
United Kingdom
Prior art keywords
alkyl
acid
compounds
prepared
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1243073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB1243073A priority Critical patent/GB1436593A/en
Priority to CH332974A priority patent/CH583688A5/xx
Priority to AU66458/74A priority patent/AU503812B2/en
Priority to AR252719A priority patent/AR213712A1/en
Priority to DE2411885A priority patent/DE2411885A1/en
Priority to HUSI1384A priority patent/HU168559B/hu
Priority to ES424238A priority patent/ES424238A1/en
Priority to CA194,875A priority patent/CA1052788A/en
Priority to SU742005426A priority patent/SU625600A3/en
Priority to JP2957974A priority patent/JPS537406B2/ja
Priority to FR7408610A priority patent/FR2221144B1/fr
Priority to BE142041A priority patent/BE812339A/en
Priority to IE542/74A priority patent/IE39166B1/en
Priority to AT217874A priority patent/AT336579B/en
Priority to NL747403543A priority patent/NL154496B/en
Priority to ZA00741711A priority patent/ZA741711B/en
Publication of GB1436593A publication Critical patent/GB1436593A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1436593 Substituted acetamides SCIENCE UNION ET CIE SOC FRANCAISE DE REMEDICALE 15 March 1974 [15 March 1973] 12430/73 Heading C2C Novel substituted acetamides of the Formula I in which R 1 is H or C 1 -C 6 alkyl; R 2 and R 3 each are C 1 -C 6 alkyl, cycloalkyl or aryl; R 6 is H or C 1 -C 6 alkyl; R 4 is H, C 1 -C 6 alkyl, C 2 -C 10 alkenyl or benzyl; R 5 is C 1 -C 6 alkyl, C 2 -C 10 alkenyl, C 2 -C 6 alkynyl or aryl-C 1 -C 4 alkyl; or R 4 and R 5 together with the nitrogen atom to which they are attached form a 5 to 8 membered saturated heterocyclic ring which is optionally substituted and may contain a further hetereo atom, and R<SP>1</SP> is H or acyl, and the acid addition salts thereof are prepared by reaction carboxylic acids of the formula or reactive functional derivatives thereof with amines of the formula compounds of the Formula I above in which R 4 is H may also be obtained by the hydrogenolysis or acid hydrolysis of the corresponding compounds in which R 4 is benzyl, and those in which R<SP>1</SP> is acyl by acylating the corresponding compounds in which R<SP>1</SP> is H. (2,2<SP>1</SP>,6,6<SP>1</SP> - Tetramethyldiphenyl)acetyl chloride is prepared by reacting thionyl chloride with the acid, resulting from the hydrolysis of the corresponding nitrile, which is made by reacting silver cyanide with (2,21,6,61-tetramethyldiphenyl)chloromethane. Similarly the following are prepared: (4,41 - difluorodiphenyl)acetyl chloride, (4,4<SP>1</SP> - difluorodiphenyl)acetic acid, and (4,4<SP>1</SP>-difluorodiphenyl)acetonitrile. Dicyclopropylacetyl chloride is prepared by reacting thionyl chloride with dicyclopropylacetic acid, obtained by oxidizing dicyclopropylacetaldehyde. (2,2<SP>1</SP>,3-Trimethoxy-5<SP>1</SP>-methyldiphenyl)acetic acid and (2-methoxy-2<SP>1</SP>-methylthio- 5<SP>1</SP>-methyldiphenyl)acetic acid are also obtained by oxidating the corresponding acetaldehydes. Pharmaceutical compositions, suitable for oral, parenteral, sublingual or rectal administration, contain the above compounds or non- toxic acid addition salts thereof in admixture or conjunction with pharmaceutical carriers. The compounds anti-arhythmic, cardio-depressive, vasodilatory, anti-hypertensive and anti-aggregating properties.
GB1243073A 1973-03-15 1973-03-15 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp Expired GB1436593A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB1243073A GB1436593A (en) 1973-03-15 1973-03-15 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp
CH332974A CH583688A5 (en) 1973-03-15 1974-03-08
AU66458/74A AU503812B2 (en) 1973-03-15 1974-03-08 N-substituted acetamides
AR252719A AR213712A1 (en) 1973-03-15 1974-03-11 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF AMINO-PROPYLACETAMIDES N-SUBSTITUTED PARTICULARLY USEFUL AS THERAPEUTIC AGENTS AND MORE PARTICULARLY ANTIARRHYTHMIC, CARDIO-REGULATORY AND ANTI-HYPERTENSIC
DE2411885A DE2411885A1 (en) 1973-03-15 1974-03-12 SUBSTITUTED ACETAMIDES, THE PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
HUSI1384A HU168559B (en) 1973-03-15 1974-03-12
ES424238A ES424238A1 (en) 1973-03-15 1974-03-13 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp
CA194,875A CA1052788A (en) 1973-03-15 1974-03-13 Process for the preparation of novel n-substituted acetamides and derivatives thereof
SU742005426A SU625600A3 (en) 1973-03-15 1974-03-14 Method of producing substituted acetamides or their salts
JP2957974A JPS537406B2 (en) 1973-03-15 1974-03-14
FR7408610A FR2221144B1 (en) 1973-03-15 1974-03-14
BE142041A BE812339A (en) 1973-03-15 1974-03-14 NEW ACETAMIDES SUBSTITUTES
IE542/74A IE39166B1 (en) 1973-03-15 1974-03-14 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them
AT217874A AT336579B (en) 1973-03-15 1974-03-15 PROCESS FOR PREPARING NEW N-SUBSTITUTED ACETAMIDES
NL747403543A NL154496B (en) 1973-03-15 1974-03-15 PROCESS FOR THE PREPARATION OF COMPOUNDS WITH CARDIOVASCULAR ACTION, PROCEDURE FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH SUCH ACTION AND FORMED MEDICINAL PRODUCT.
ZA00741711A ZA741711B (en) 1973-03-15 1974-03-15 New n-substituted acetamides, processes for their preparation and pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1243073A GB1436593A (en) 1973-03-15 1973-03-15 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

Publications (1)

Publication Number Publication Date
GB1436593A true GB1436593A (en) 1976-05-19

Family

ID=10004460

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1243073A Expired GB1436593A (en) 1973-03-15 1973-03-15 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

Country Status (16)

Country Link
JP (1) JPS537406B2 (en)
AR (1) AR213712A1 (en)
AT (1) AT336579B (en)
AU (1) AU503812B2 (en)
BE (1) BE812339A (en)
CA (1) CA1052788A (en)
CH (1) CH583688A5 (en)
DE (1) DE2411885A1 (en)
ES (1) ES424238A1 (en)
FR (1) FR2221144B1 (en)
GB (1) GB1436593A (en)
HU (1) HU168559B (en)
IE (1) IE39166B1 (en)
NL (1) NL154496B (en)
SU (1) SU625600A3 (en)
ZA (1) ZA741711B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094793A1 (en) 2003-04-24 2004-11-04 Byd Company Limited Muffler and catalytic converter devices
EP1640359A2 (en) * 1997-12-10 2006-03-29 Nps Pharmaceuticals, Inc. Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720915C2 (en) * 1977-05-10 1986-04-17 Kali-Chemie Pharma Gmbh, 3000 Hannover N? 1? -Acyl-2-hydroxy-1,3-diaminopropanes and drugs containing these compounds as an active ingredient
ES469020A1 (en) * 1977-05-10 1979-09-01 Kali Chemie Pharma Gmbh N1-acyl-N2-phenyldiaminopropanols and pharmaceutical compositions thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1640359A2 (en) * 1997-12-10 2006-03-29 Nps Pharmaceuticals, Inc. Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides
EP1640359A3 (en) * 1997-12-10 2006-04-05 Nps Pharmaceuticals, Inc. Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides
WO2004094793A1 (en) 2003-04-24 2004-11-04 Byd Company Limited Muffler and catalytic converter devices

Also Published As

Publication number Publication date
IE39166B1 (en) 1978-08-16
NL7403543A (en) 1974-09-17
JPS49134619A (en) 1974-12-25
AU503812B2 (en) 1979-09-20
JPS537406B2 (en) 1978-03-17
SU625600A3 (en) 1978-09-25
HU168559B (en) 1976-05-28
DE2411885A1 (en) 1974-09-26
AT336579B (en) 1977-05-10
ATA217874A (en) 1976-09-15
CA1052788A (en) 1979-04-17
IE39166L (en) 1974-09-15
BE812339A (en) 1974-09-16
ES424238A1 (en) 1976-05-16
FR2221144A1 (en) 1974-10-11
FR2221144B1 (en) 1978-07-21
CH583688A5 (en) 1977-01-14
AU6645874A (en) 1975-09-11
ZA741711B (en) 1975-04-30
AR213712A1 (en) 1979-03-15
NL154496B (en) 1977-09-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee