GB1179262A - New Amides of Aliphatic Carboxylic Acids - Google Patents

New Amides of Aliphatic Carboxylic Acids

Info

Publication number
GB1179262A
GB1179262A GB411667A GB411667A GB1179262A GB 1179262 A GB1179262 A GB 1179262A GB 411667 A GB411667 A GB 411667A GB 411667 A GB411667 A GB 411667A GB 1179262 A GB1179262 A GB 1179262A
Authority
GB
United Kingdom
Prior art keywords
acid
compound
prepared
formula
alkapolyene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB411667A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB1179262A publication Critical patent/GB1179262A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,179,262. Aliphatic acid amides. J. R. GEIGY A.G. 27 Jan., 1967 [28 Jan., 1966], No. 4116/67. Heading C2C. [Also in Division C3] Novel amides of Formula I in which R 1 -CO- is the acyl radical of an alkanoic, alkenoic or alkapolyene acid having 6 to 14 carbon atoms, R 2 is halogen, C 1-4 alkyl, C 1-6 alkoxy, C 1-4 alkylthio, C 1-4 alkenyloxy, C 1-4 alkanoylamino or C 1-5 (alkoxycarbonyl) and R 3 is hydrogen or C 1-4 alkyl, and their acid addition salts, are prepared by reacting an acid of formula R 1 -COOH, or a reactive functional derivative thereof, with a compound of Formula II or a reactive functional derivative thereof, and, if desired, adding bromine to an alkenoic or alkapolyene acid amide obtained, purifying the addition product by crystallization or another usual process and then debrominating, and/or, if desired, converting a compound obtained of Formula I into an acid addition salt. In a modification of this process, a saturated bromine addition compound of an alkenoic or alkapolyene acid having 6 to 14 carbon atoms, or a reactive functional derivative thereof, is reacted with a compound II and the product is debrominated in known manner. The compounds I in which R 2 is C 1-4 alkanoylamino, can also be prepared by alkanoylation of the corresponding free amino compounds. p-Nitrophenyl 10-undecanoate is prepared by reacting p-nitrophenol with 10-undecenoic acid. N - (5 - amino - 2 - pyridyl) - 10 - undecenamide is prepared by reacting 2-amino-5-nitropyridine with 10-undecenoyl chloride, reducing the resulting N-(5-nitro-2-pyridyl)-10-undecenamide. Pharmaceutical compositions having antiviral and tumour inhibiting properties, for oral, parenteral, rectal or topical administration, comprise a compound I, or an acid addition salt thereof, together with a carrier.
GB411667A 1966-01-28 1967-01-27 New Amides of Aliphatic Carboxylic Acids Expired GB1179262A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH123466A CH500980A (en) 1966-01-28 1966-01-28 Aliphatic carboxylic acid amides having anti-viral and

Publications (1)

Publication Number Publication Date
GB1179262A true GB1179262A (en) 1970-01-28

Family

ID=4205609

Family Applications (1)

Application Number Title Priority Date Filing Date
GB411667A Expired GB1179262A (en) 1966-01-28 1967-01-27 New Amides of Aliphatic Carboxylic Acids

Country Status (13)

Country Link
AT (2) AT268281B (en)
BE (1) BE693263A (en)
CH (1) CH500980A (en)
DE (1) DE1695006A1 (en)
DK (1) DK115393B (en)
ES (1) ES336148A1 (en)
FR (2) FR1510319A (en)
GB (1) GB1179262A (en)
GR (1) GR35673B (en)
IL (1) IL27336A (en)
NL (1) NL6701359A (en)
NO (1) NO122420B (en)
SE (1) SE331096B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516812A (en) * 2013-04-19 2016-06-09 リサーチ コーポレーション ファウンデーション オブ ヨンナム ユニバーシティ Amidopyridol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing it as an active ingredient

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516812A (en) * 2013-04-19 2016-06-09 リサーチ コーポレーション ファウンデーション オブ ヨンナム ユニバーシティ Amidopyridol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing it as an active ingredient

Also Published As

Publication number Publication date
NL6701359A (en) 1967-07-31
CH500980A (en) 1970-12-31
SE331096B (en) 1970-12-14
BE693263A (en) 1967-07-27
GR35673B (en) 1968-10-17
NO122420B (en) 1971-06-28
AT268281B (en) 1969-02-10
DE1695006A1 (en) 1971-02-25
FR6381M (en) 1968-10-14
DK115393B (en) 1969-10-06
AT268283B (en) 1969-02-10
FR1510319A (en) 1968-01-19
IL27336A (en) 1971-02-25
ES336148A1 (en) 1968-04-01

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