GB1179263A - New Amides of Aliphatic Carboxylic Acids their Production and Use - Google Patents

New Amides of Aliphatic Carboxylic Acids their Production and Use

Info

Publication number
GB1179263A
GB1179263A GB4117/67A GB411767A GB1179263A GB 1179263 A GB1179263 A GB 1179263A GB 4117/67 A GB4117/67 A GB 4117/67A GB 411767 A GB411767 A GB 411767A GB 1179263 A GB1179263 A GB 1179263A
Authority
GB
United Kingdom
Prior art keywords
acid
formula
compound
prepared
reactive functional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4117/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB1179263A publication Critical patent/GB1179263A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Edible Oils And Fats (AREA)
  • Saccharide Compounds (AREA)

Abstract

1,179,263. Aliphatic acid amides. J. R. GEIGY A.G. 27 Jan., 1967 [28 Jan., 1966], No. 4117/67. Heading C2C. [Also in Division C3] Novel amides of Formula I:- in which R 1 -CO- is the acyl radical of an alkanoic or alkenoic acid having 15-22 carbon atoms, R 2 is halogen, C 1-4 alkyl, C 1-6 alkoxy, C 1-4 alkenyloxy, C 1-4 alkylthio, C 1-4 alkanoylamino or C 1-5 -(alkoxycarbonyl) and R 3 is hydrogen or C 1-4 alkyl, and their acid addition salts, are prepared by reacting an acid of formula R 1 -COOH, or a reactive functional derivative thereof, with a compound of Formula II:- or a reactive functional derivative thereof, and, if desired, adding bromine to an alkenoic acid amide of Formula I obtained, purifying the addition product by crystallization or another usual process and then debrominating, and/or, if desired, converting a compound obtained of Formula I into an acid addition salt. In a modification of this process, a saturated bromine addition product of a C 15-22 alkenoic acid, or a reactive functional derivative thereof, is reacted with a compound II and the product is debrominated in known manner. The compounds I in which R 2 is C 1-4 alkanoylamino, are also prepared by alkanoylation of the corresponding free amino compounds. p-Nitrophenyl oleate is prepared by reacting p-nitrophenol with oleic acid. Pharmaceutical compositions having antiviral and tumour inhibiting properties, for oral, parenteral, rectal or topical administration, comprise a compound I, or an acid addition salt thereof, together with a carrier.
GB4117/67A 1966-01-28 1967-01-27 New Amides of Aliphatic Carboxylic Acids their Production and Use Expired GB1179263A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH123666 1966-01-28

Publications (1)

Publication Number Publication Date
GB1179263A true GB1179263A (en) 1970-01-28

Family

ID=4205652

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4117/67A Expired GB1179263A (en) 1966-01-28 1967-01-27 New Amides of Aliphatic Carboxylic Acids their Production and Use

Country Status (13)

Country Link
AT (2) AT269880B (en)
BE (1) BE693264A (en)
CH (2) CH484906A (en)
DE (1) DE1695007A1 (en)
DK (1) DK115260B (en)
ES (1) ES336149A1 (en)
FR (2) FR1510320A (en)
GB (1) GB1179263A (en)
GR (1) GR35672B (en)
IL (1) IL27338A (en)
NL (1) NL6701360A (en)
NO (1) NO122421B (en)
SE (1) SE329848B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017096A (en) * 2015-07-03 2015-11-04 厦门大学 Oleoylethanolamide derivatives, preparation method and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX22406A (en) * 1989-09-15 1994-01-31 Pfizer NEW DERIVATIVES OF N-ARIL AND N-HETEROARILAMIDAS AND UREA AS INHIBITORS OF ACIL COENZYME A: ACIL TRANSFERASA DEL COLESTEROL (ACAT).

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017096A (en) * 2015-07-03 2015-11-04 厦门大学 Oleoylethanolamide derivatives, preparation method and application thereof

Also Published As

Publication number Publication date
NL6701360A (en) 1967-07-31
SE329848B (en) 1970-10-26
FR1510320A (en) 1968-01-19
CH484906A (en) 1970-01-31
BE693264A (en) 1967-07-27
DK115260B (en) 1969-09-22
CH491112A (en) 1970-05-31
ES336149A1 (en) 1968-10-16
DE1695007A1 (en) 1971-02-25
FR6382M (en) 1968-10-14
AT267526B (en) 1969-01-10
GR35672B (en) 1968-10-17
AT269880B (en) 1969-04-10
NO122421B (en) 1971-06-28
IL27338A (en) 1971-02-25

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