GR35672B - METHOD FOR THE PREPARATION OF NEW AMIDES OF ALIPHPATIC CARBONIC ACIDS. - Google Patents
METHOD FOR THE PREPARATION OF NEW AMIDES OF ALIPHPATIC CARBONIC ACIDS.Info
- Publication number
- GR35672B GR35672B GR670135672A GR670135672A GR35672B GR 35672 B GR35672 B GR 35672B GR 670135672 A GR670135672 A GR 670135672A GR 670135672 A GR670135672 A GR 670135672A GR 35672 B GR35672 B GR 35672B
- Authority
- GR
- Greece
- Prior art keywords
- general formula
- acid
- preparation
- crystallization
- derivative
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000004653 carbonic acids Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000005108 alkenylthio group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 abstract 1
- 150000003927 aminopyridines Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Edible Oils And Fats (AREA)
- Saccharide Compounds (AREA)
Abstract
έθοδος παρασκευής νέων αμιδίων αλειφατικών καρβονοξέων συμφώνως προς τον γενικόν τύπον Ι: [*] εις ον σημαίνουν R1-CO- το ακυλυπόλοιπον ενός αλκανοξέος ή αλκενοξέος μετά 15-22 ατόμων άνθρακος, R2 εν άτομον αλογόνου, μίαν κατωτέραν αλκυλ-, αλκοξυ-, αλκενυλοξυ-, αλκυλοθειο-, αλκενυλοθειο-, αλκανοϋλαμινο-, ή αλκοξυκαρβονυλομάδα και R3 υδρογόνον ή εν κατώτερον αλκυλυπόλοιπον, και των δια προσθήκης αλάτων αυτών μετ' ανοργάνων και οργανικών οξέων, χαρακτηριζομένη εκ του ότι φέρομεν προς αντίδρασιν εν οξύ του γενικού τύπου ΙΙ: R1 - CO - OH εις ον το R1 - CO - έχει την ανωτέρω αναφερθείσαν σημασίαν, ήεν ικανόν προς αντίδρασιν θεμελιώδες παράγωγον ενός τοιούτου οξέος μετά μιας υποκατεστημένης εις τον πυρήνα αμινοπυριδίνης ή υποκατεστημένης εις τον πυρήνα αλκυλαμινοπυριδίνης του γενικού τύπου ΙΙΙ: [*] εις ον R2 και R3 έχουσι την ανωτέρω αναφερθείσαν σημασίαν, ή μεθ' ενός ικανού προς αντίδρασιν θεμελιώδους παραγώγου αυτού, και εάν επιθυμούμεν προσθέτομεν εις εν λαμβανόμενον αλκεναμίδιον του γενικού τύπου Ι βρώμιον, καθαρίζομεν το προϊόν προσθήκης δια κρυσταλώσεως ή μιας άλλης συνήθους μεθόδου και ακολούθως αποβρωμιούμεν, και/ή εάν επιθυμούμενμετατρέπομεν μίαν λαμβανομένην ένωσιν του γενικούτύπου προς εν δια προσθήκης άλας μεθ' ενός ανοργάνου ή οργανικού οξέος. Process for the preparation of novel aliphatic carboxylic amides according to general formula I: [*] εις ον σημαίνουν R1-CO- is the acyl residue of an alkanoic acid or alkenic acid having 15-22 carbon atoms, R 2 in a halogen atom, a lower alkyl-, alkoxy-, alkenyloxy-, alkylthio-, alkenylthio-, alkanoylamino-, or alkoxycarbonyl group and R3 hydrogen or lower alkyl residue, and addition salts thereof with inorganic and organic acids, characterized in that they are reacted with an acid of general formula II: R1 - CO - OH in which R1 - CO - has the above-mentioned significance, or is capable of reacting a fundamental derivative of such an acid with a nucleoside-substituted amino-pyridine or nucle-substituted alkylaminopyridine of general formula III: [*] to R2 and R3 having the above-mentioned significance, or with a reactive fundamental derivative thereof, and if desired to be added to the alkenamide of general formula I bromine, purify the additive by crystallization or other by crystallization or other , and / or if desired a converted compound of the general formula to a salt for addition with an inorganic or organic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH123666 | 1966-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR35672B true GR35672B (en) | 1968-10-17 |
Family
ID=4205652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR670135672A GR35672B (en) | 1966-01-28 | 1967-01-27 | METHOD FOR THE PREPARATION OF NEW AMIDES OF ALIPHPATIC CARBONIC ACIDS. |
Country Status (13)
| Country | Link |
|---|---|
| AT (2) | AT267526B (en) |
| BE (1) | BE693264A (en) |
| CH (2) | CH491112A (en) |
| DE (1) | DE1695007A1 (en) |
| DK (1) | DK115260B (en) |
| ES (1) | ES336149A1 (en) |
| FR (2) | FR1510320A (en) |
| GB (1) | GB1179263A (en) |
| GR (1) | GR35672B (en) |
| IL (1) | IL27338A (en) |
| NL (1) | NL6701360A (en) |
| NO (1) | NO122421B (en) |
| SE (1) | SE329848B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| CN105017096B (en) * | 2015-07-03 | 2017-08-08 | 厦门大学 | A kind of Oleoyl monoethanolamide derivative, its preparation method and application |
-
1966
- 1966-01-28 CH CH116769A patent/CH491112A/en not_active IP Right Cessation
- 1966-01-28 CH CH116869A patent/CH484906A/en not_active IP Right Cessation
-
1967
- 1967-01-21 DE DE19671695007 patent/DE1695007A1/en active Pending
- 1967-01-27 NL NL6701360A patent/NL6701360A/xx unknown
- 1967-01-27 ES ES336149A patent/ES336149A1/en not_active Expired
- 1967-01-27 FR FR92773A patent/FR1510320A/en not_active Expired
- 1967-01-27 GR GR670135672A patent/GR35672B/en unknown
- 1967-01-27 BE BE693264D patent/BE693264A/xx unknown
- 1967-01-27 GB GB4117/67A patent/GB1179263A/en not_active Expired
- 1967-01-27 IL IL2733867A patent/IL27338A/en unknown
- 1967-01-27 DK DK50767A patent/DK115260B/en unknown
- 1967-01-27 NO NO16659267A patent/NO122421B/no unknown
- 1967-01-27 SE SE122067A patent/SE329848B/xx unknown
- 1967-01-27 AT AT80167A patent/AT267526B/en active
- 1967-01-27 AT AT82068A patent/AT269880B/en active
- 1967-04-26 FR FR104244A patent/FR6382M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6701360A (en) | 1967-07-31 |
| DK115260B (en) | 1969-09-22 |
| DE1695007A1 (en) | 1971-02-25 |
| AT269880B (en) | 1969-04-10 |
| FR6382M (en) | 1968-10-14 |
| IL27338A (en) | 1971-02-25 |
| BE693264A (en) | 1967-07-27 |
| AT267526B (en) | 1969-01-10 |
| SE329848B (en) | 1970-10-26 |
| GB1179263A (en) | 1970-01-28 |
| CH491112A (en) | 1970-05-31 |
| ES336149A1 (en) | 1968-10-16 |
| FR1510320A (en) | 1968-01-19 |
| NO122421B (en) | 1971-06-28 |
| CH484906A (en) | 1970-01-31 |
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